多功能节能高效洗涤组合橱柜的设计

该产品是集洗涤、烘干、消毒、循环水再利用于一体的多功能组合橱柜,具有空间小,功能全,成本低,结构简单,操作方便,节能环保等特点.     

超声波法测量套管应力

根据超声波法测量材料应力原理，采用声速仪对套管进行了应力测量。试验结果表明，声速与套管的应力变化有较明确的对应关系，单轴应力的测量结果具有相当高的精度。该试验可为套损预测和套管超声应力检测仪的研制提供可靠的依据。     

循环流化床锅炉燃烧系统的模块化仿真模型

在STAR－90一体化仿真支撑系统下，开发了循环流化床锅炉（CFBB）燃烧系统主要过程的仿真算法，并采用工程块化建模方法建立了大型CFBB燃烧系统的仿真模型。仿真试验表明，所建立的模型运行稳定,可以正确反应实际系统的工作过程。工程模块化的CFBB燃烧系统仿真模型，通过合理的系统分解和模块结构设计，可以使得模型的修改量降到最小，模型的表现形式与实际过程的流程相似，更利于用户理解和掌握。     

短信息辅助办公自动化系统的分析与设计

企业在日常运行中,员工在工作时间内,经常会发生因故晚到、因公或因私外出、请假等不在岗位的情况,员工的协作人员或上级主管在找其合作或分配工作时找不到人,只能询问其周边员工,获知其去向或不在岗位的原因,极端情况是周边的人都不知道,从而影响工作的正常进行;企业因业务需要经常给客户发信息通知,大客户量情况下电话通知方式效率低,而邮件的方式时效性不强。论文给出了一个完整的短信息辅助的办公自动化系统分析与设计方案来解决上述问题。     

Neutralization of human immunodeficiency virus type 1 by antibody to gp120 is determined primarily by occupancy of sites on the virion irrespective of epitope specificity

We investigated the relative importance of binding site occupancy and epitope specificity in antibody neutralization of human immunodeficiency virus (HIV) type 1 (HIV-1). The neutralization of a T-cell-line-adapted HIV-1 isolate (MN) was analyzed with a number of monovalent recombinant Fab fragments (Fabs) and monoclonal antibodies with a range of specificities covering all confirmed gp120-specific neutralization epitopes. Binding of Fabs to recombinant monomeric gp120 was determined by surface plasmon resonance, and binding of Fabs and whole antibodies to functional oligomeric gp120 was determined by indirect immunofluorescence and flow cytometry on HIV-infected cells. An excellent correlation between neutralization and oligomeric gp120 binding was observed, and a lack of correlation with monomeric gp120 binding was confirmed. A similar degree of correlation was observed between oligomeric gp120 binding and neutralization with a T-cell-line-adapted HIV-1 molecular clone (Hx10). The ratios of oligomer binding/neutralization titer fell, in general, within a relatively narrow range for antibodies to different neutralization epitopes. These results suggest that the occupancy of binding sites on HIV-1 virions is the major factor in determining neutralization, irrespective of epitope specificity. Models to account for these observations are proposed.     

Respiratory activity of the rat posterior cricoarytenoid muscle

An anatomic and electrophysiological study of the rat posterior cricoarytenoid (PCA) muscle is described. The intramuscular nerve distribution of the PCA branch of the recurrent laryngeal nerve was demonstrated by a modified Sihler's stain. The nerve to the PCA was found to terminate in superior and inferior branches with a distribution that appeared to be confined to the PCA muscle. Electromyography (EMG) recordings of PCA muscle activity in anesthetized rats were obtained under stereotaxic control together with measurement of phrenic nerve discharge. A total of 151 recordings were made in 7 PCA muscles from 4 rats. Phasic inspiratory activity with a waveform similar to that of phrenic nerve discharge was found in 134 recordings, while a biphasic pattern with both inspiratory and post-inspiratory peaks was recorded from random sites within the PCA muscle on 17 occasions. The PCA EMG activity commenced 24.6 +/- 2.2 milliseconds (p < .0001) before phrenic nerve discharge. The results are in accord with findings of earlier studies that show that PCA muscle activity commences prior to inspiratory airflow and diaphragmatic muscle activity. The data suggest that PCA and diaphragm motoneurons share common or similar medullary pre-motoneurons. The earlier onset of PCA muscle activity may indicate a role for medullary pre-inspiratory neurons in initiating PCA activity.     

Relevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design

Understanding the antibody response in HIV-1 infection is important to vaccine design. We have studied the antibody response to HIV-1 envelope at the molecular level and determined the characteristics of neutralizing and non-neutralizing antibodies. These antibodies were isolated from phage display libraries prepared from long-term seropositive asymptomatic individuals. The HIV-1 envelope is presented to the immune system in several antigenically distinct configurations: unprocessed gp160, gp120 and gp41 subunits and native envelope, each of which may be important in eliciting an antibody response in HIV-1 infection. The antibodies tested characteristically had poor affinities for native envelope as expressed on the surface of virions or infected cells, but had high affinities against non-native forms of HIV-1 envelope (viral debris). An exceptionally potent neutralizing antibody in contrast, bound native envelope with equivalent or somewhat higher affinity than this. This indicates that the antibody response in HIV-1 infection is principally elicited by viral debris rather than virions, and that these antibodies bind and neutralize viruses sub-optimally. Potential vaccines should be designed to elicit responses against native envelope.     

Toxicity of fotemustine in rat hepatocytes and mechanism-based protection against it

Fotemustine is a relatively novel DNA-alkylating 2-chloroethyl-substituted N-nitrosourea (CENU) drug, clinically used for the treatment of disseminated malignant melanoma in different visceral and non-visceral tissues. Thrombocytopenia has been observed in patients treated with fotemustine and liver and renal toxicities as well. In this study, firstly the metabolism of fotemustine was investigated in vitro and secondly the undesired cytotoxicity of fotemustine as well as different ways of protection against it. In rat hepatocytes, chosen as a model system, fotemustine was shown to cause lactate dehydrogenase (LDH) leakage, glutathione (GSH) depletion, GSSG-formation and lipid peroxidation (LPO). A reactive metabolite, DEP-isocyanate, is most likely responsible for these undesired cytotoxic effects. Based on the observed cytotoxicity mechanisms, chemoprotection with several sulfhydryl-containing nucleophiles and antioxidants was investigated. The sulfhydryl nucleophiles; GSH, N-acetyl-L-cysteine (NAC) and glutathione isopropylester (GSH-IP) protected almost completely against fotemustine-induced LDH-leakage and LPO. NAC and GSH protected partly against fotemustine-induced GSH-depletion. The antioxidant, vitamin E protected completely against fotemustine-induced LPO, but only partly against fotemustine-induced LDH-leakage and not against GSH-depletion. Ebselen, a peroxidase-mimetic organoselenium compound, did not show protective effects against the cytotoxicity of fotemustine, possibly because GSH is required for the bioactivation of ebselen. It is concluded that co-administration of sulfhydryl nucleophiles, in particular NAC and GSH-IP, possibly in combination with antioxidants, such as vitamin E, are effective against the toxicity of fotemustine in vitro. It might, therefore, be worthwhile to investigate the cytoprotective potency of these agents against undesired toxicities of fotemustine in vivo as well.     

The adjacent pixel nonlinearity: problems and solutions

The adjacent pixel nonlinearity refers to the dependence of the luminance of a given pixel on the preceding pixel or pixels. We measured this nonlinearity for two CRT displays by measuring the average luminances of a variety of test patterns with different luminance jumps. A two-stage model proposed by Mulligan and Stone was used to fit the data [Mulligan, J.B. & Stone, L. S., (1989). Journal of the Optical Society of America A, 6, 1217-1227 (1989)]. The results show that the model predicts our data well. Based on our measurements and the modeling results, a double-entry look-up table was created to compensate for this nonlinearity. This compensation method works even if the current pixel depends on more than one preceding pixel. Observers commented that at small pixel sizes the compensation results in a sharp, accurate image. Advantages and problems of this compensation will be discussed.