A new adaptation of mapping method to study mixing of multiphase flows in mixers with complex geometries

The main objective of the present work is to modify the traditional mapping method for the simulation of distributive mixing of multiphase flows in geometries involving moving parts such as, internal mixers or twin-screw extruders without a limitation on their geometrical periodicity. The periodicity condition, limits the results of traditional mapping method to tracking mapping mesh between specific discrete time intervals or distances for that geometry is repeated, hence, result is only for fixed orientation of rotors. Imaginary domain method is introduced to track mapping mesh from one state to the next free of geometrical periodicity limitations. In this work the method is introduced and its applicability and accuracy is discussed in details. A two-dimensional (2D) simulation of mixing of two Newtonian fluids with different viscosities in an intermeshing internal mixer is used as a test case study. In this example the key issues of ability to predict mixing state in details for all orientations of rotors is presented. To reduce diffusion errors of mapping method in the boundaries of the rotors, mapping mesh refinement technique that relies upon one single reference mesh is also presented.     

Hesperidin Promotes Osteogenesis and Modulates Collagen Matrix Organization and Mineralization In Vitro and In Vivo

This study evaluated the direct effect of a phytochemical, hesperidin, on pre-osteoblast cell function as well as osteogenesis and collagen matrix quality, as there is little known about hesperidin’s influence in mineralized tissue formation and regeneration. Hesperidin was added to a culture of MC3T3-E1 cells at various concentrations. Cell proliferation, viability, osteogenic gene expression and deposited collagen matrix analyses were performed. Treatment with hesperidin showed significant upregulation of osteogenic markers, particularly with lower doses. Mature and compact collagen fibrils in hesperidin-treated cultures were observed by picrosirius red staining (PSR), although a thinner matrix layer was present for the higher dose of hesperidin compared to osteogenic media alone. Fourier-transform infrared spectroscopy indicated a better mineral-to-matrix ratio and matrix distribution in cultures exposed to hesperidin and confirmed less collagen deposited with the 100-µM dose of hesperidin. In vivo, hesperidin combined with a suboptimal dose of bone morphogenetic protein 2 (BMP2) (dose unable to promote healing of a rat mandible critical-sized bone defect) in a collagenous scaffold promoted a well-controlled (not ectopic) pattern of bone formation as compared to a large dose of BMP2 (previously defined as optimal in healing the critical-sized defect, although of ectopic nature). PSR staining of newly formed bone demonstrated that hesperidin can promote maturation of bone organic matrix. Our findings show, for the first time, that hesperidin has a modulatory role in mineralized tissue formation via not only osteoblast cell differentiation but also matrix organization and matrix-to-mineral ratio and could be a potential adjunct in regenerative bone therapies.     

Gain‐scheduled filtering for linear parameter‐varying systems using inexact scheduling parameters with bounded variation rates

This paper is concerned with the problem of full‐order H₂ linear parameter‐varying filter design for continuous‐time systems with bounded rate of variations under the condition that the scheduling parameters do not exactly fit the real ones. The scheduling parameters and their derivatives are supposed to belong to polytopes with known vertices. The synthesis conditions are formulated in terms of parameter‐dependent bilinear matrix inequalities by means of parameter‐dependent Lyapunov function and introducing some extra variables for the filter design. An iterative procedure is presented to cast the bilinear matrix inequalities problem into a linear matrix inequality optimization problem. The design of robust filters for both time‐varying and time‐invariant systems can be viewed as particular cases of the proposed method. The merit of the method presented in this paper lies in two fields. The first pertains to dealing with the measurement uncertainty in a less conservative manner than available approaches in the gain‐scheduled filtering problem. The second is to provide more efficient methods than the existing ones in the literature for the robust filter design. Copyright © 2015 John Wiley & Sons, Ltd.     

Column and batch reactive transport experiment parameter estimation using a genetic algorithm

This paper focuses on the application of a genetic algorithm (GA) in estimating the fate and transport parameters of a reacting solute from the column and batch experiments involving a saturated porous medium. A program is developed using C++ to model the column and batch data using kinetically controlled one- or two-site sorption models including linear and/or nonlinear forms. The objective of the algorithm is to minimize the sum of squared differences between the measured and modeled solute concentration data associated with column effluent (i.e., “breakthrough curves”). The GA is capable of estimating transport and reactions parameters such as forward and reverse reaction rates and parameters of the nonlinear reaction models, from a given set of measured data. Further simulations have been performed to estimate the appropriate configurations of the GA, which assist the method in estimating the fate and transport parameters more efficiently. It is shown that a wide range of the GA parameters can lead to convergence to appropriate estimations. The results obtained from this study show that the capability of GAs to fit the column and batch experiment data is promising.     

Corona virus optimization (CVO): a novel optimization algorithm inspired from the Corona virus pandemic

This research introduces a new probabilistic and meta-heuristic optimization approach inspired by the Corona virus pandemic. Corona is an infection that originates from an unknown animal virus, which is of three known types and COVID-19 has been rapidly spreading since late 2019. Based on the SIR model, the virus can easily transmit from one person to several, causing an epidemic over time. Considering the characteristics and behavior of this virus, the current paper presents an optimization algorithm called Corona virus optimization (CVO) which is feasible, effective, and applicable. A set of benchmark functions evaluates the performance of this algorithm for discrete and continuous problems by comparing the results with those of other well-known optimization algorithms. The CVO algorithm aims to find suitable solutions to application problems by solving several continuous mathematical functions as well as three continuous and discrete applications. Experimental results denote that the proposed optimization method has a credible, reasonable, and acceptable performance.

     

A comparative survey of artificial intelligence applications in finance: artificial neural networks, expert system and hybrid intelligent systems

Nowadays, many current real financial applications have nonlinear and uncertain behaviors which change across the time. Therefore, the need to solve highly nonlinear, time variant problems has been growing rapidly. These problems along with other problems of traditional models caused growing interest in artificial intelligent techniques. In this paper, comparative research review of three famous artificial intelligence techniques, i.e., artificial neural networks, expert systems and hybrid intelligence systems, in financial market has been done. A financial market also has been categorized on three domains: credit evaluation, portfolio management and financial prediction and planning. For each technique, most famous and especially recent researches have been discussed in comparative aspect. Results show that accuracy of these artificial intelligent methods is superior to that of traditional statistical methods in dealing with financial problems, especially regarding nonlinear patterns. However, this outperformance is not absolute.     

Integration of genetic fuzzy systems and artificial neural networks for stock price forecasting

Stock market prediction is regarded as a challenging task in financial time-series forecasting. The central idea to successful stock market prediction is achieving best results using minimum required input data and the least complex stock market model. To achieve these purposes this article presents an integrated approach based on genetic fuzzy systems (GFS) and artificial neural networks (ANN) for constructing a stock price forecasting expert system. At first, we use stepwise regression analysis (SRA) to determine factors which have most influence on stock prices. At the next stage we divide our raw data into k clusters by means of self-organizing map (SOM) neural networks. Finally, all clusters will be fed into independent GFS models with the ability of rule base extraction and data base tuning. We evaluate capability of the proposed approach by applying it on stock price data gathered from IT and Airlines sectors, and compare the outcomes with previous stock price forecasting methods using mean absolute percentage error (MAPE). Results show that the proposed approach outperforms all previous methods, so it can be considered as a suitable tool for stock price forecasting problems.     

An artificial negotiating agent modeling approach embedding dynamic offer generating and cognitive layer

In this paper, a dynamic offer generating unit and cognitive layer are suggested for artificial agents based negotiation systems. For this purpose, first, adaptive time and behavior dependent tactics are developed taking advantages from time continuity and dynamics aspects (features) integrated in their modeling. Then, a negotiation strategy (bilateral over single issue) based on these two tactics is suggested. Second, a cognitive negotiation model for a negotiator agent is developed using Win-Lose and Win-Win orientations which will be formed based on personality factors. Afterwards, an experimental validation is conducted for testing applicability of time dependent tactics, the effect of offering time, and the effect of cognitive orientations (Win-Lose and Win-Win) on final negotiation outcomes. The results prove the applicability of the suggested time and behavior dependent tactics as well as the proposed cognitive negotiation model.     

Towards a continuous microfluidic rheometer

In a previous paper we presented a way to measure the rheological properties of complex fluids on a microfluidic chip (Guillot et al., Langmuir 22:6438, 2006). The principle of our method is to use parallel flows between two immiscible fluids as a pressure sensor. In fact, in a such flow, both fluids flow side by side and the size occupied by each fluid stream depends only on both flow rates and on both viscosities. We use this property to measure the viscosity of one fluid knowing the viscosity of the other one, both flow rates and the relative size of both streams in a cross-section. We showed that using a less viscous fluid as a reference fluid allows to define a mean shear rate with a low standard deviation in the other fluid. This method allows us to measure the flow curve of a fluid with less than 250 μL of fluid. In this paper we implement this principle in a fully automated set up which controls the flow rate, analyzes the picture and calculates the mean shear rate and the viscosity of the studied fluid. We present results obtained for Newtonian fluids and complex fluids using this set up and we compare our data with cone and plate rheometer measurements. By adding a mixing stage in the fluidic network we show how this set up can be used to characterize in a continuous way the evolution of the rheological properties as a function of the formulation composition. We illustrate this by measuring the rheological curve of four formulations of polyethylene oxide solution with only 1.3 mL of concentrated polyethylene oxide solution. This method could be very useful in screening processes where the viscosity range and the behavior of the fluid to an applied stress must be evaluated.