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1.
JL Cohen J Cheirif DS Segar LD Gillam JS Gottdiener E Hausnerova DE Bruns 《Canadian Metallurgical Quarterly》1998,32(3):746-752
We investigated whether changes in iron metabolism and the transferrin receptor (TRF-R) expression were involved in the antileukaemic effects of arabinoside cytosine (ara-C). Treatment with 100 nM ara-C for 48h reduced thymidine uptake and increased the surface expression of the TRF-R on leukaemic blasts derived from 13/16 (81%) patients and on the HL-60 and U-937 cell lines. Whereas intracellular non-haem iron was strongly depleted 24 h after ara-C addition, TRF-R up-regulation and recovery of intracellular non-haem iron concentration occurred together after a longer exposure of the cultured cells to the drug. Since iron is an essential regulator of cell proliferation we have evaluated the effects of the combination between ara-C and the iron chelator desferioxamine (DSF) on the growth of HL-60 and U-937 cells. We found that desferioxamine strongly potentiated the effects of ara-C on leukaemic cell growth inhibition and apoptosis. This is the first report of a positive interaction between ara-C and an iron chelator in terms of antileukaemic effects. 相似文献
2.
Polyurethanes obtained from 4,4′‐diphenylmethane diisocyanate (MDI) and polydiols with different molecular weights (polyethylene glycol and polyoxypropylene diols) were used as modifiers for diglycidyl ether of bisphenol A. Impact strength (IS), critical stress intensity factor (KC), flexural strength and flexural strain at break were measured as a function of polyurethane (PUR) type and content. Scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and infrared spectroscopy (FTIR) were employed for the structure and morphology analysis. It was found that the addition of polyurethane with an excess of isocyanate groups to epoxy resin resulted in the formation of a grafted interpenetrating polymer network structure. The mechanical properties of epoxy resin were improved with 5 and 10% PUR. Moreover, it was observed that composites containing PUR based on higher molecular weight (PUR 1002 and PUR 2002) with long flexible segments exhibited higher impact strength while PUR prepared from polyethylene glycol had a higher flexural energy to break and a higher flexural modulus. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011 相似文献
3.
The rheological behavior of highly filled polymer systems used in powder injection molding (PIM) technology strongly influences the final properties of the products. In this study, the capillary flow data of multi‐component polymer binders—based on polyethylene, paraffin, ethylene‐based copolymers, and polyethylene glycol—compounded with three various hard‐metal carbide powders were employed. The rheology of such highly filled (up to 50 vol%) multiphase systems is necessarily a complex phenomenon characterized by strain dependent, non‐Newtonian properties complicated by flow instabilities and yield. Over 15 mathematical models proposed for highly filled systems were tested, some of them calculating the maximum filler loading. Due to the complex structure of the filler (irregular shape, particle size distribution) and a multi‐component character of the binder, the applicability of these models varied with the powder‐binder systems studied. However, the particular values of maximum loadings are in good accordance with the predictions based on powder characteristics. Simple modification of Frankel‐Acrivos model to the systems containing unimodal hard‐metal carbide powders with particles of an irregular shape and broad particle size distribution gave precise agreement between experimental data and model prediction. POLYM. COMPOS., 26:29–36, 2005. © 2004 Society of Plastics Engineers. 相似文献
4.
In this research, rheological parameters of cement suspensions modified with different doses of two types of superplasticizers (SPs) were evaluated with an alternative method of centrifugation. It was determined that the critical normal and shear stresses (yield values), and the water/solid ratio alter with the additive dose, the additive type as well and the magnitude of centrifugal forces. The results obtained reveal that the method of centrifugation might serve for determination of dispersing effectiveness of SPs and rheological parameters of suspensions in general. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013 相似文献
5.
Berenika Hausnerova Lucie Marcanikova Petr Filip Petr Saha 《Polymer Engineering and Science》2011,51(7):1376-1382
Analyses crucial to optimize powder injection molding of feedstock based on aluminum oxide powder and multicomponent polymeric binder are provided with the aim to obtain defect‐free, high density parts. As the critical step of the process is the flow of highly filled (60 vol%) compound into a mold cavity, rheological properties supplemented by thermal and pressure‐volume‐temperature characteristics are measured and described. Upon shear deformation the feedstock undergoes structural changes, which are quantified in terms of yield stresses obtained using Herschel‐Bulkley and Casson methods. Further, the rheological model is developed to describe the flow behavior of the feedstock in the whole shear rate range measured. Thermogravimetric analysis is performed to optimize debinding step of the process, and two possible ways of the binder removal are proposed: purely thermal andcombined solvent/thermal. The quality of the final sintered parts is demonstrated on scanning electron microscopic images of their surfaces. POLYM. ENG. SCI., 2011. © 2011 Society of Plastics Engineers 相似文献
6.
Julian Rech Esther Ramakers-van Dorp Bernhard Mginger Berenika Hausnerova 《International journal of molecular sciences》2022,23(22)
Evaluation of creep compliance of particulate composites using empirical models always provides parameters depending on initial stress and material composition. The effort spent to connect model parameters with physical properties has not resulted in success yet. Further, during the creep, delamination between matrix and filler may occur depending on time and initial stress, reducing an interface adhesion and load transfer to filler particles. In this paper, the creep compliance curves of glass beads reinforced poly(butylene terephthalate) composites were fitted with Burgers and Findley models providing different sets of time-dependent model parameters for each initial stress. Despite the finding that the Findley model performs well in a primary creep, the Burgers model is more suitable if secondary creep comes into play; they allow only for a qualitative prediction of creep behavior because the interface adhesion and its time dependency is an implicit, hidden parameter. As Young’s modulus is a parameter of these models (and the majority of other creep models), it was selected to be introduced as a filler content-dependent parameter with the help of the cube in cube elementary volume approach of Paul. The analysis led to the time-dependent creep compliance that depends only on the time-dependent creep of the matrix and the normalized particle distance (or the filler volume content), and it allowed accounting for the adhesion effect. Comparison with the experimental data confirmed that the elementary volume-based creep compliance function can be used to predict the realistic creep behavior of particulate composites. 相似文献
7.
Berenika M. Winclawska 《Scientometrics》1996,35(3):387-391
The author discusses inefficiencies of Garfield'sSocial Sciences Citation Index to measure quality of a discipline in a national context. She proposes an alternative measurement tool to the Garfield's index. The example of sociology was selected; an index of Polish sociology was created and data from it was compared with data retrieved from the SSCI. The two sets were compared to show greater sensitivity of the locally created index. 相似文献
8.
Vanda Kuthanová Berenika Hausnerová Takeshi Kitano Monika Lapčíková Petr Sáha 《应用聚合物科学杂志》2011,119(2):989-999
Influence of processing methods, in terms of comparing compression and injection moldings, on the rheological behavior of polycarbonate (PC)/acrylonitrile‐butadiene‐styrene (ABS) blends and PC/ABS/glass fibers composites is presented. Blend compositions and fiber content are considered as material variables. For blends, the effect of the processing route on the viscoelastic functions is evident only for low shearing frequencies. Injection molding created morphology with cocontinuous character, while compression molded blends have “relaxed” structure, where dispersed phase domains are several times larger than in injection molded ones. The glass fiber reinforcement led to the significant differences in viscoelastic properties of composites processed by injection and compression molding. Injected composites have both moduli always higher than compression molded. Also, fiber lengths are reduced more for compressing molding. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011 相似文献
9.
Michaela Pelíkov Natalia E. Kazantseva Jan Proke Berenika Hausnerov Petr Sha 《Polymer Composites》2014,35(11):2234-2240
The objective of this work is to study the effect of electrical conductivity and physical‐mechanical properties of carbon black (CB) filled polymer composites. This goal is achieved by synthesizing epoxy/silicon phase separated blend structure of composites filled with CB. The percolation threshold of epoxy/silicone/CB composites decreased and the total conductivity increased compared to the pure epoxy/CB composite. A threefold increase was obtained with tensile strength of epoxy/silicone/CB composite with 25 wt% of silicone and 5 wt% of CB in comparison with epoxy/CB systems. This composite has conductivity of about 10−6 S/cm, which is six orders of magnitude higher than for epoxy/CB composites at the same concentration of CB. POLYM. COMPOS., 35:2234–2240, 2014. © 2014 Society of Plastics Engineers 相似文献
10.
Petr Slobodian Robert Olejnik Jiri Matyas Berenika Hausnerova Pavel Riha Romana Danova Dusan Kimmer 《International journal of molecular sciences》2022,23(22)
We prepared electroactive PVDF membranes, which were subjected to mechanical as well as dual electro–mechanical signals and their responses were detected by the evoked electrical pulses. The aim was to obtain primarily electric energy that could be used for light signalling, sensing of the membrane properties and membrane motion detection. The obtained data showed the unique as well as usable properties of PVDF membranes. From this point of view, the gain and analysis of the electrical responses to combined electro–mechanical loads of PVDF membranes have been important in terms of identifying the mechanism. The detected electrical response of the PVDF membrane to their electro–mechanical pulses also indicated the possibility of using this phenomenon. Among others, it suggests monitoring of membrane fouling and use for a self-cleaning mechanism. 相似文献