Effect of surfactant replacement therapy on the outcome of premature infants with respiratory distress syndrome

Lung surfactant replacement has been tested clinically in recent years. In this study the outcome of 31 premature infants with moderate to severe neonatal respiratory distress syndrome (RDS) treated with surfactant was compared to that of 74 prematures with RDS treated conventionally by positive pressure ventilation and supportive care. The groups were well matched for gestational age, birthweight, sex, and Apgar scores at 1 and 5 min. Surfactant treatment resulted in a significant decrease in mortality--from 36.6% in the untreated group to 12.9% in the surfactant-treated group (P < 0.04). This improvement in survival was seen also in prematures with a birthweight < 1,000 g; in the untreated group mortality was 57.6% compared to 23.5% in the treated group (P < 0.05). The incidence of pneumothorax was lower in the treated group--42% vs. 13% (P < 0.01). Surfactant treatment resulted in a trend of more survivors without bronchopulmonary dysplasia or intraventricular hemorrhage, even though surfactant therapy did not change the incidence of either.     

Temporary Tasks Assignment Resolved

Among all basic on-line load balancing problems, the only unresolved problem was load balancing of temporary tasks on unrelated machines. This open problem existed for almost a decade, see [12]. We resolve this problem by providing an inapproximability result. In addition, a newer open question is to identify the dependency of the competitive ratio on the durations of jobs in the case where durations are known. We resolve this problem by characterizing this dependency. Finally, we provide a PTAS for the off-line problem with a fixed number of machines and show a 2 -inapproximability result for the general case.     

Combinatorial Algorithms for the Unsplittable Flow Problem

We provide combinatorial algorithms for the unsplittable flow problem (UFP) that either match or improve the previously best results. In the UFP we are given a (possibly directed) capacitated graph with n vertices and m edges, and a set of terminal pairs each with its own demand and profit. The objective is to connect a subset of the terminal pairs each by a single flow path subject to the capacity constraints such that the total profit of the connected pairs is maximized.We consider three variants of the problem. First is the classical UFP in which the maximum demand is at most the minimum edge capacity. It was previously known to have an O(√m) approximation algorithm; the algorithm is based on the randomized rounding technique and its analysis makes use of the Chernoff bound and the FKG inequality.We provide a combinatorial algorithm that achieves the same approximation ratio and whose analysis is considerably simpler. Second is the extended UFP in which some demands might be higher than edge capacities. Our algorithm for this case improves the best known approximation ratio. We also give a lower bound that shows that the extended UFP is provably harder than the classical UFP. Finally, we consider the bounded UFP in which the maximum demand is at most 1/K times the minimum edge capacity for some K > 1. Here we provide combinatorial algorithms that match the currently best known algorithms. All of our algorithms are strongly polynomial and some can even be used in the online setting.     

The void coefficient ‘Paradox’ for tight water lattices

The void coefficients in tight water lattices with enriched plutonium fuel were calculated. It was found that for the same fuel, the void coefficient is negative when the moderator is light water and positive when the moderator is heavy water. The explanation to this presumed anomally is given.     

Qualitative model for creep of AZ91D magnesium alloy

Creep properties of specimens taken from the core of AZ91D magnesium alloy ingots (9 pct Al, 1 pct Zn) were examined in the temperature range of 120 °C to 180 °C and stress range of 40 to 115 MPa. Solution-treated and aged creep specimens were also tested. The creep rates observed were about three orders of magnitude lower than those of pure magnesium, and elongations to fracture were seen to be at least twice those of pure magnesium. A minimum creep rate was reached after approximately 2/3 of the creep life of the specimens (except for the aged specimens, in which the minimum creep rate appears at the beginning of the test). A qualitative model for the creep process in proposed on the basis of the creep tests and optical, scanning electron, and transmission electron microscopy. This model proposes that dislocation motion on additional slip systems is the primary creep mechanism and that cracking acts as a stress relief mechanism. Structural instability dictates the amount of hardening and, hence, creep resistance.     

Clients' sexually inappropriate behaviors directed toward clinicians: Conceptualization and management.

Sexually inappropriate behaviors in clinical settings are relatively common occurrences that may negatively affect the therapeutic process. For example, more than half of female psychologists have reported at least 1 incident in which a client responded in a sexually inappropriate manner. Thus, it is important for clinicians to understand inappropriate behaviors and respond in a manner that is both personally satisfying and helpful to the client. A framework for conceptualizing these behaviors is proposed, as well as components for, and examples of, therapeutic responses. Recommendations are provided for preventive measures to decrease the likelihood of inappropriate behaviors and for systemic approaches to benefit professional training in regards to these issues. Our aim is to stimulate further discussion of sexually inappropriate behaviors specifically by facilitating psychotherapists' ability to address clients' within-session sexual behavior, facilitating speculation of the antecedents of and motivations behind such behaviors, and facilitating discussion of such behaviors within supervision and, more broadly, within training programs. (PsycINFO Database Record (c) 2010 APA, all rights reserved)