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排序方式: 共有920条查询结果,搜索用时 15 毫秒
1.
Virginia Veronica Visconti Ida Cariati Simona Fittipaldi Riccardo Iundusi Elena Gasbarra Umberto Tarantino Annalisa Botta 《International journal of molecular sciences》2021,22(8)
DNA methylation is one of the most studied epigenetic mechanisms that play a pivotal role in regulating gene expression. The epigenetic component is strongly involved in aging-bone diseases, such as osteoporosis and osteoarthritis. Both are complex multi-factorial late-onset disorders that represent a globally widespread health problem, highlighting a crucial point of investigations in many scientific studies. In recent years, new findings on the role of DNA methylation in the pathogenesis of aging-bone diseases have emerged. The aim of this systematic review is to update knowledge in the field of DNA methylation associated with osteoporosis and osteoarthritis, focusing on the specific tissues involved in both pathological conditions. 相似文献
2.
Veronica Cocetta Vincenzo Quagliariello Francesco Fiorica Massimiliano Berretta Monica Montopoli 《International journal of molecular sciences》2021,22(4)
Resistance to chemotherapy still remains a major challenge in the clinic, impairing the quality of life and survival rate of patients. The identification of unconventional chemosensitizing agents is therefore an interesting aspect of cancer research. Resveratrol has emerged in the last decades as a fascinating molecule, able to modulate several cancer-related molecular mechanisms, suggesting a possible application as an adjuvant in cancer management. This review goes deep into the existing literature concerning the possible chemosensitizing effect of resveratrol associated with the most conventional chemotherapeutic drugs. Despite the promising effects observed in different cancer types in in vitro studies, the clinical translation still presents strong limitations due to the low bioavailability of resveratrol. Recently, efforts have been moved in the field of drug delivery to identifying possible strategies/formulations useful for a more effective administration. Despite the necessity of a huge implementation in this research area, resveratrol appears as a promising molecule able to sensitize resistant tumors to drugs, suggesting its potential use in therapy-refractory cancer patients. 相似文献
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Leonardo Candela Fuat Akal Henri Avancini Donatella Castelli Luigi Fusco Veronica Guidetti Christoph Langguth Andrea Manzi Pasquale Pagano Heiko Schuldt Manuele Simi Michael Springmann Laura Voicu 《International Journal on Digital Libraries》2007,7(1-2):59-80
This paper introduces DILIGENT, a digital library infrastructure built by integrating digital library and Grid technologies and resources. This infrastructure
allows different communities to dynamically build specialised digital libraries capable to support the entire e-Science knowledge
production and consumption life-cycle by using shared computing, storage, content, and application resources. The paper presents
some of the main software services that implement the DILIGENT system. Moreover, it exemplifies the provided features by presenting how the DILIGENT infrastructure is being exploited in supporting the activity of user communities working in the Earth Science Environmental
sector.
This work is partially funded by the European Commission in the context of the DILIGENT project, under the 2nd call of FP6 IST priority. 相似文献
5.
A comparative analysis of methods for pruning decision trees 总被引:14,自引:0,他引:14
Esposito F. Malerba D. Semeraro G. Kay J. 《IEEE transactions on pattern analysis and machine intelligence》1997,19(5):476-491
In this paper, we address the problem of retrospectively pruning decision trees induced from data, according to a top-down approach. This problem has received considerable attention in the areas of pattern recognition and machine learning, and many distinct methods have been proposed in literature. We make a comparative study of six well-known pruning methods with the aim of understanding their theoretical foundations, their computational complexity, and the strengths and weaknesses of their formulation. Comments on the characteristics of each method are empirically supported. In particular, a wide experimentation performed on several data sets leads us to opposite conclusions on the predictive accuracy of simplified trees from some drawn in the literature. We attribute this divergence to differences in experimental designs. Finally, we prove and make use of a property of the reduced error pruning method to obtain an objective evaluation of the tendency to overprune/underprune observed in each method 相似文献
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8.
Abdominal aortic dissection is a rare pathology. As far as we are concerned, only 59 cases have been reported in the English literature. In the last two years, two cases were treated at our Institution. Both were males, over 70 years of age. They were evaluated with ultrasonography, angiography (1 case) and Magnetic Resonance Imaging which showed localised dissection of the abdominal aorta with aneurysmal dilatation. They underwent surgical treatment with good results. At 1 and 2 years from operation both patients are alive and well. A postoperative ultrasonography didn't show any residual dissection. 相似文献
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10.
S. Rombetto Yu. N. Ovchinnikov V. Corato P. Silvestrini E. Esposito C. Granata M. Russo R. Russo B. Ruggiero 《Open Systems & Information Dynamics》2007,14(2):209-216
We study the resonant quantum behaviour of a macroscopic superconducting system interacting with an external field. First
we consider the resonant tunneling assisted by microwave frequency in the moderate underdamped quantum regime. Then we consider
the resonant process in the extreme underdamped limit. In both regimes we have investigated a small frequency range, where
resonant phenomena take place. The transition probability W from the left to the right potential well has been numerically
calculated for an rf-SQUID as function of the external flux φ
x
for both regimes. Results indicate that, in a proper frequency and φ
x
range, the transition probability W can present two or three resonant peaks, depending on the damping regime. 相似文献