Preparation and Characterization of Magnetite–Chitosan Nanoparticles and Evaluation of Their Cytotoxicity Effects on MCF7 and Fibroblast Cells

Nowadays, magnetic nanoparticles play a key role in drug treatment. However, if they are uncoated, they might aggregate and cause embolism in drug delivery. To avoid this, they are generally coated with polymers. In this investigation, magnetic nanoparticles (MNPs) were coated with chitosan through in situ co-precipitation process and their properties in addition to their cytotoxicity in MCF7 and fibroblast cells were analyzed. The results showed MNPs–chitosan nanoparticles would contain an average mean diameter of 32 nm and a saturation magnetization (M _S) value of 38.87 emu/g. To characterize the synthesized nanoparticles in terms of structural, morphological and magnetic properties, Fourier transform infrared (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermal gravimetric analysis (TGA) and vibrating sample magnetometry (VSM) studies were used. Toxicity test was also done to investigate whether their presence would cause any toxicity in the body; in addition, antibacterial assay was done to analyze if nanoparticles could be used as an antimicrobial agent.     

Surface characterization and biological properties of regular dentin,demineralized dentin,and deproteinized dentin

Bone autografts are often used for reconstruction of bone defects; however, due to the limitations of autografts, researchers have been in search of bone substitutes. Dentin is of particular interest for this purpose due to high similarity to bone. This in vitro study sought to assess the surface characteristics and biological properties of dentin samples prepared with different treatments. This study was conducted on regular (RD), demineralized (DemD), and deproteinized (DepD) dentin samples. X-ray diffraction and Fourier transform infrared spectroscopy were used for surface characterization. Samples were immersed in simulated body fluid, and their bioactivity was evaluated under a scanning electron microscope. The methyl thiazol tetrazolium assay, scanning electron microscope analysis and quantitative real-time polymerase chain reaction were performed, respectively to assess viability/proliferation, adhesion/morphology and osteoblast differentiation of cultured human dental pulp stem cells on dentin powders. Of the three dentin samples, DepD showed the highest and RD showed the lowest rate of formation and deposition of hydroxyapatite crystals. Although, the difference in superficial apatite was not significant among samples, functional groups on the surface, however, were more distinct on DepD. At four weeks, hydroxyapatite deposits were noted as needle-shaped accumulations on DemD sample and numerous hexagonal HA deposit masses were seen, covering the surface of DepD. The methyl thiazol tetrazolium, scanning electron microscope, and quantitative real-time polymerase chain reaction analyses during the 10-day cell culture on dentin powders showed the highest cell adhesion and viability and rapid differentiation in DepD. Based on the parameters evaluated in this in vitro study, DepD showed high rate of formation/deposition of hydroxyapatite crystals and adhesion/viability/osteogenic differentiation of human dental pulp stem cells, which may support its osteoinductive/osteoconductive potential for bone regeneration.     

Axial offset control of PWR nuclear reactor core using intelligent techniques

Improved load following capability is one of the main technical performances of advanced PWR (APWR). Controlling the nuclear reactor core during load following operation encounters some difficulties. These difficulties mainly arise from nuclear reactor core limitations in local power peaking, while the core is subject to large and sharp variation of local power density during transients. Axial offset (AO) is the parameter usually used to represent of core power peaking, in form of a practical parameter. This paper, proposes a new intelligent approach to AO control of PWR nuclear reactors core during load following operation. This method uses a neural network model of the core to predict the dynamic behavior of the core and a fuzzy critic based on the operator knowledge and experience for the purpose of decision-making during load following operations. Simulation results show that this method can use optimum control rod groups maneuver with variable overlapping and may improve the reactor load following capability.     

Design of a low cross‐talk micro‐coil array for micro‐scale MRI

Design of magnetic resonance micro‐coil arrays with low cross‐talk among the coils can be the main challenge to improve the effectiveness of magnetic resonance micro‐imaging because the electrical cross‐talk which is mainly due to the inductive coupling perturbs the sensitivity profile of the array and causes image artifacts. In this work, a capacitive decoupling network with N(M ? 1) + (N ? 1)(M ? 2) capacitors is proposed to reduce the inductive coupling in an N × M array. A 3 × 3 array of optimized micro‐coils is designed using the finite element simulations and all the needed elements for the array equivalent circuit are extracted in order to evaluate the effectiveness of the proposed decoupling method by assessing the reduction of the coupled signals after employing the capacitive network on the circuit. The achieved results for the designed array show that the high cross‐talk level is reduced by the factor of 2.2–3.4 after employing the capacitive network. By employing this method of decoupling, the adjacent coils in each row and inner columns can be decoupled properly while the minimum decoupling belongs to the outer columns because of the lack of all necessary decoupling capacitances for these columns. The main advantages of the proposed decoupling method are its efficiency and design easiness which facilitates the design of dense arrays with the properly decoupled coils, especially the inner coils which are more coupled due to their neighbors. © 2013 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 23, 353–359, 2013     

Towards the performance evaluation of 4th generation wireless communication standards: LTE versus Mobile WiMAX

Advances in wireless communication protocols and networking toward support of the next generation of mobile and radio broadband technologies have contributed to a strong competition among various telecommunication standards in particular Long Term Evolution (LTE) and Mobile Worldwide Interoperability for Microwave Access (WiMAX). In this paper, we provide an in‐depth comparison analysis of LTE and Mobile WiMAX at the physical (PHY) layer by studying the most similar PHY configuration scenarios for these two technologies. Our study includes a throughput analysis of downlink (DL) and uplink (UL) transmissions in time division duplex with the least overhead possible and different antenna schemes as well as modulation and code rates. This study also performs an overhead analysis in both protocols to provide a more in‐depth understanding of the PHY layer capacity in various PHY layer configurations. Our simulation results generally show higher performance for LTE in both DL and UL transmission with 7 Mbps in DL and 5 Mbps in UL, when using one antenna port. However, by increasing the number of antennas for multiple‐input/multiple‐output configurations, the results illustrate a reduction in the performance of LTE compared to Mobile WiMAX. This arises from the increase in reference signal overhead in LTE from 4.7% in single‐input/single‐output (SISO) to 14.28% in 4 × 4 multiple‐input/multiple‐output (MIMO). Copyright © 2013 John Wiley & Sons, Ltd.     

Siloxane‐based segmented poly(urethane‐urea) elastomer: Synthesis and characterization

A series of segmented poly(urethane‐urea) block copolymers were synthesized with varying proportions of polydimethylsiloxane diols in combination with polytetramethylene ether glycol (PTMG) using 4,4'‐methylenediphenyl diisocyanate followed by chain extension with a (50:50 mol %) mixture of 4,4'‐methylene‐bis(3‐chloro‐2,6‐diethylaniline) (M‐CDEA) and 1,4‐butanediol (BD). The molecular structures of polydimethylsiloxane urethane‐ureas were characterized by ATR‐FTIR and ¹H‐NMR spectroscopic techniques. Distribution of siloxane domain and its influence on surface roughness were investigated by scanning electron microscopy (SEM) and atomic forced microscopy (AFM), respectively. The mechanical and thermal properties of the elastomers were studied by thermogravimetric analysis, dynamical mechanical thermal analysis, and tensile measurement. The results showed that by incorporation of polydimethylsiloxane diol and M‐CDEA chain extender in polyurethane formulation, some improvements in thermal stability, fire resistance and surface hydrophilicity were achieved. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 1743–1751, 2013     

Modeling and Control of Linear Two-time Scale Systems: Applied to Single-Link Flexible Manipulator

This paper deals with the problem of H _∞ control of linear two-time scale systems. The authors’ attention is focused on the robust regulation of the system based on a new modeling approach under the assumption of norm-boundedness of the fast dynamics. In the proposed approach, the fast dynamics are treated as a norm-bounded disturbance (dynamic uncertainty). In this view, the synthesis is performed only for the certain dynamics of the two-time scale system, whose order is less than that of the original system. It should be noted, however, that this scheme is significantly different from the conventional approaches of order reduction for linear two-time scale systems. Specifically, in the present work, explicitly or implicitly, all the dynamics of the system are taken into consideration. In other words, the portion that is treated as a perturbation is incorporated in the design by its maximum possible gain – in the L ₂ sense – over different values of the inputs. One of the advantagesof this approach is that – unlike in the conventional approaches of the order reduction – the reduced-order system still keeps some information of the ‘deleted’ subsystem. Also, we consider the robust stability analysis and stability bound improvement of perturbed parameter (ɛ) in the two-time scale systems by using linear fractional transformations and structured singular values (μ) approach. In this direction, by introducing the parametric uncertainty and dynamic uncertainty in the two-time scale systems, we represent the system as a standard μ-interconnection framework by using linear fractional transformations, and derive a set of new stability conditions for the system in the frequency domain. The exact solution of ɛ-bound is characterized. It is shown that, in spite of the coupling between the dynamic uncertainties and certain dynamics, the designed H _∞ controller stabilizes the overall closed-loop system, in the presence of norm-bounded disturbances. To show the effectiveness of the approach, the modeling of the single-link flexible manipulator and control of the Tip-position of the manipulator by utilizing the mentioned method are presented in the case study.