全文获取类型
收费全文 | 292篇 |
免费 | 21篇 |
专业分类
电工技术 | 5篇 |
化学工业 | 67篇 |
金属工艺 | 5篇 |
机械仪表 | 4篇 |
建筑科学 | 9篇 |
矿业工程 | 1篇 |
能源动力 | 6篇 |
轻工业 | 98篇 |
水利工程 | 4篇 |
无线电 | 24篇 |
一般工业技术 | 26篇 |
冶金工业 | 33篇 |
原子能技术 | 2篇 |
自动化技术 | 29篇 |
出版年
2023年 | 1篇 |
2022年 | 11篇 |
2021年 | 10篇 |
2020年 | 10篇 |
2019年 | 10篇 |
2018年 | 10篇 |
2017年 | 13篇 |
2016年 | 8篇 |
2015年 | 8篇 |
2014年 | 21篇 |
2013年 | 19篇 |
2012年 | 16篇 |
2011年 | 23篇 |
2010年 | 15篇 |
2009年 | 10篇 |
2008年 | 17篇 |
2007年 | 9篇 |
2006年 | 10篇 |
2005年 | 10篇 |
2004年 | 5篇 |
2003年 | 6篇 |
2002年 | 2篇 |
2001年 | 3篇 |
2000年 | 2篇 |
1999年 | 8篇 |
1998年 | 17篇 |
1997年 | 7篇 |
1996年 | 6篇 |
1995年 | 4篇 |
1994年 | 3篇 |
1993年 | 8篇 |
1992年 | 3篇 |
1991年 | 3篇 |
1990年 | 1篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1976年 | 2篇 |
排序方式: 共有313条查询结果,搜索用时 15 毫秒
1.
Scientometrics - The expanding presence of multinational research teams highlights the importance of characterizing the outcomes of international collaboration. Herein, we characterize the... 相似文献
2.
Rodrigo Brquez Mario Espinoza Rodrigo Ormeo 《Journal of the science of food and agriculture》1994,66(2):181-186
Total volatile basic nitrogen (TVB-N) as a measure of protein degradation and total microbial counts or stored raw mackerel (Trachurus murphy), which had been treated with chemical preservatives, were compared with the TVB-N and microbial counts of untreated fish. In unpreserved fish, decomposition of fish protein was rapid. Treatment of mackerel with acetic (1000-5000 μg kg?1), which was the most effective of the parameters studied, approximately halved the rate of increase in TVB-N compared with the untreated samples. Changes in the total microbial counts presented a similar trend. 相似文献
3.
4.
Luis O. Soto-Rojas Mar Pacheco-Herrero Paola A. Martínez-Gmez B. Berenice Campa-Crdoba Ricardo Aptiga-Prez Marcos M. Villegas-Rojas Charles R. Harrington Fidel de la Cruz Linda Garcs-Ramírez Jos Luna-Muoz 《International journal of molecular sciences》2021,22(4)
Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide. Histopathologically, AD presents with two hallmarks: neurofibrillary tangles (NFTs), and aggregates of amyloid β peptide (Aβ) both in the brain parenchyma as neuritic plaques, and around blood vessels as cerebral amyloid angiopathy (CAA). According to the vascular hypothesis of AD, vascular risk factors can result in dysregulation of the neurovascular unit (NVU) and hypoxia. Hypoxia may reduce Aβ clearance from the brain and increase its production, leading to both parenchymal and vascular accumulation of Aβ. An increase in Aβ amplifies neuronal dysfunction, NFT formation, and accelerates neurodegeneration, resulting in dementia. In recent decades, therapeutic approaches have attempted to decrease the levels of abnormal Aβ or tau levels in the AD brain. However, several of these approaches have either been associated with an inappropriate immune response triggering inflammation, or have failed to improve cognition. Here, we review the pathogenesis and potential therapeutic targets associated with dysfunction of the NVU in AD. 相似文献
5.
Luis O. Soto-Rojas B. Berenice Campa-Crdoba Charles R. Harrington Andrs Salas-Casas Mario Hernandes-Alejandro Ignacio Villanueva-Fierro Marely Bravo-Muoz Linda Garcs-Ramírez Fidel De La Cruz-Lpez Miguel ngel Ontiveros-Torres Goar Gevorkian Mar Pacheco-Herrero Jos Luna-Muoz 《International journal of molecular sciences》2021,22(7)
Alzheimer’s disease (AD) is a neurodegenerative disease, characterized histopathologically by intra-neuronal tau-related lesions and by the accumulation of amyloid β-peptide (Aβ) in the brain parenchyma and around cerebral blood vessels. According to the vascular hypothesis of AD, an alteration in the neurovascular unit (NVU) could lead to Aβ vascular accumulation and promote neuronal dysfunction, accelerating neurodegeneration and dementia. To date, the effects of insoluble vascular Aβ deposits on the NVU and the blood–brain barrier (BBB) are unknown. In this study, we analyze different Aβ species and their association with the cells that make up the NVU. We evaluated post-mortem AD brain tissue. Multiple immunofluorescence assays were performed against different species of Aβ and the main elements that constitute the NVU. Our results showed that there are insoluble vascular deposits of both full-length and truncated Aβ species. Besides, insoluble aggregates are associated with a decrease in the phenotype of the cellular components that constitute the NVU and with BBB disruption. This approach could help identify new therapeutic targets against key molecules and receptors in the NVU that can prevent the accumulation of vascular fibrillar Aβ in AD. 相似文献
6.
7.
Traceability is recognized to be important for supporting agile development processes. However, after analyzing many of the
existing traceability approaches it can be concluded that they strongly depend on traditional development process characteristics.
Within this paper it is justified that this is a drawback to support adequately agile processes. As it is discussed, some
concepts do not have the same semantics for traditional and agile methodologies. This paper proposes three features that traceability
models should support to be less dependent on a specific development process: (1) user-definable traceability links, (2) roles,
and (3) linkage rules. To present how these features can be applied, an emerging traceability metamodel (TmM) will be used
within this paper. TmM supports the definition of traceability methodologies adapted to the needs of each project. As it is
shown, after introducing these three features into traceability models, two main advantages are obtained: 1) the support they
can provide to agile process stakeholders is significantly more extensive, and 2) it will be possible to achieve a higher
degree of automation. In this sense it will be feasible to have a methodical trace acquisition and maintenance process adapted
to agile processes. 相似文献
8.
The Australian lungfish is an endangered native species currently protected under various state, federal and international agreements. Scarce information on their early life history is available due to the absence of juveniles collected in the wild. This has led to concerns about the sustainability of the species and become a driver for the conservation effort for Australian lungfish. This study aimed to consolidate knowledge on the critical hydraulic habitat requirements of this species within a water resource management context. In this study, spawning of Australian lungfish was found to be a seasonal strategy that is highly reliant on a variable low‐flow regime within riverine habitat. Suitable conditions for spawning were characterized by small flow events in early‐to‐mid spring when water temperatures are between 18 and 28 °C, leading to oviposition on short dense macrophytes in shallow water. Importantly, many of the key environmental factors driving the ecological response are manageable through existing water resource infrastructure. Specifically, releases from water storages within the current distribution of Australian lungfish should mimic the natural inflow and temperature regime within the spawning period, and also provide suitable riverine habitat within projected full supply limits. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
9.
10.