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1.
Youri Oh Hoyong Jung Hyejin Kim Jihyun Baek Joonhong Jun Hyunwook Cho Daseul Im Jung-Mi Hah 《International journal of molecular sciences》2021,22(8)
Polo-like kinase 1 (PLK1) plays an important role in cell cycle progression and proliferation in cancer cells. PLK1 also contributes to anticancer drug resistance and is a valuable target in anticancer therapeutics. To identify additional effective PLK1 inhibitors, we performed QSAR studies of two series of known PLK1 inhibitors and proposed a new structure based on a hybridized 3D-QSAR model. Given the hybridized 3D-QSAR models, we designed and synthesized 4-benzyloxy-1-(2-arylaminopyridin-4-yl)-1H-pyrazole-3-carboxamides, and we inspected its inhibitory activities to identify novel PLK1 inhibitors with decent potency and selectivity. 相似文献
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Piyawattanametha W. Patterson P.R. Hah D. Toshiyoshi H. Wu M.C. 《Journal of microelectromechanical systems》2005,14(6):1329-1338
In this paper, we present the design, fabrication, and measurements of a two-dimensional (2-D) optical scanner with electrostatic angular vertical comb (AVC) actuators. The scanner is realized by combining a foundry-based surface-micromachining process (Multi-User MEMS Processes-MUMPs) with a three-mask deep-reactive ion-etching (DRIE) postfabrication process. The surface-micromachining provides versatile mechanical design and electrical interconnect while the bulk micromachining offers high-aspect ratio structures leading to flat mirrors and high-force, large-displacement actuators. The scanner achieves dc mechanical scanning ranges of /spl plusmn/6.2/spl deg/ (at 55 Vdc) and /spl plusmn/4.1/spl deg/ (at 50 Vdc) for the inner and outer gimbals, respectively. The resonant frequencies are 315 and 144 Hz for the inner and the outer axes, respectively. The 1-mm-diameter mirror has a radius of curvature of over 50 cm. [1454]. 相似文献
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Hanyong Kim Hah Young Yoo Yong Hwan Ki Il-Kwon Kim Eui-Hong Byun Yung-Hun Yang Si Jae Park Jeong-Geol Na Hiesang Sohn Taek Lee Jung Rae Kim Chulhwan Park 《Korean Journal of Chemical Engineering》2018,35(9):1854-1859
World-wide production of l-lysine has rapidly increased in recent years. In the industrial scale production, it is cost effective to minimize waste as many waste materials are generated during downstream processing. Therefore, the conversion of crude lysine to a more valuable product reduces waste emission. In this study, 1,5-diaminopentane (DAP, trivial name: cadaverine) was produced by l-lysine decarboxylation using Hafnia alvei. The conditions of enzymatic reaction were determined. In particular, the addition of specific detergent (Brij 56) was significantly affected in the bioconversion system. Addition of hydrophobic organic solvent improved the mixing of the reactants. Finally, an industrial crude form of lysine served as a substrate. The DAP conversion by analytical, feed and industrial crude l-lysine was 93.9%, 90.3%, and 63.8%, respectively. 相似文献
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Park Jae-Hee Jeon Gyeong-Im Kim Jung-Mi Park Eunju 《Food science and biotechnology》2012,21(2):543-550
Methanol extracts of 4 different colored (red, orange, yellow, and green) bell peppers (Capsicum annuum L.) were examined to (1) determine the total phenolic content (TPC), (2) compare the antioxidant activities, (3) assess the
protective effects of extracts on H2O2-induced and 4-hydroxy-2-nonenal (HNE)-induced DNA damage using the Comet assay, and (4) examine the antiproliferative action
of their extracts on HT-29 cells. Red and orange bell peppers had significantly higher levels of TPC than yellow or green
bell peppers. Orange bell pepper exhibited the highest level of radical scavenging activity and total antioxidant activity,
while green bell pepper exhibited the highest superoxide dismutase-like activity. These results suggest that the difference
in antioxidant activities may depend on the kinds of antioxidant compounds related to the color of the pepper. It was found
a significant negative correlation between TPC and radical scavenging activity inhibiting capacity (IC)50, and a significant positive corretation between TPC and total antioxidant activity. All extracts of bell pepper inhibited
H2O2-induced and 4-hydroxy-2-nonenal-induced DNA damage in human leukocytes and showed potential toxicity on HT-29 cells. These
findings suggest that the 4 different colored bell peppers may be useful as antioxidants and cancer prevention in food. 相似文献
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Aniruddha Ray Xueding Wang Yong-Eun Koo Lee Hoe Jin Hah Gwangseong Kim Thomas Chen Daniel A. Orringer Oren Sagher Xiaojun Liu Raoul Kopelman 《Nano Research》2011,4(11):1163-1173
Distinguishing a tumor from non-neoplastic tissue is a challenging task during cancer surgery. Several attempts have been
made to use visible or fluorescent agents to aid in the visualization of a tumor during surgery. We describe a novel method
to delineate brain tumors, using a highly sensitive photoacoustic imaging technique that is enhanced by tumor-targeting blue
nanoparticles serving as a contrast agent. Experiments on phantoms and on rat brains, ex vivo, demonstrate the high sensitivity of photoacoustic imaging in delineating tumors containing contrast agent at a concentration
much lower than needed for visualization by the naked eye. The limit of detection of the system for the nanoparticles is about
0.77 μg/mL in water (equivalent to 0.84 μmol/L Coomassie Blue dye). The present exploratory study suggests that photoacoustic
imaging, when used with strongly optical absorbing contrast agents, could facilitate cancer surgery intraoperatively by revealing
the distribution and extent of the tumor.
相似文献