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排序方式: 共有808条查询结果,搜索用时 31 毫秒
1.
Anna Stasiowicz Natalia Rosiak Ewa Tykarska Maciej Kozak Jacek Jenczyk Piotr Szulc Joanna Kobus-Cisowska Kornelia Lewandowska Anita Paziska Wojciech Paziski Judyta Cielecka-Piontek 《International journal of molecular sciences》2021,22(8)
Piperine is an alkaloid that has extensive pharmacological activity and impacts other active substances bioavailability due to inhibition of CYP450 enzymes, stimulation of amino acid transporters and P-glycoprotein inhibition. Low solubility and the associated low bioavailability of piperine limit its potential. The combination of piperine with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) causes a significant increase in its solubility and, consequently, an increase in permeability through gastrointestinal tract membranes and the blood–brain barrier. X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR) were used to characterize interactions between piperine and HP-β-CD. The observed physicochemical changes should be combined with the process of piperine and CD system formation. Importantly, with an increase in solubility and permeability of piperine as a result of interaction with CD, it was proven to maintain its biological activity concerning the antioxidant potential (2,2-diphenyl-1-picryl-hydrazyl-hydrate assay), inhibition of enzymes essential for the inflammatory process and for neurodegenerative changes (hyaluronidase, acetylcholinesterase, butyrylcholinesterase). 相似文献
2.
Fernanda Monedeiro Viorica Railean-Plugaru Maciej Monedeiro-Milanowski Pawe Pomastowski Bogusaw Buszewski 《International journal of molecular sciences》2021,22(9)
Considering the advent of antibiotic resistance, the study of bacterial metabolic behavior stimulated by novel antimicrobial agents becomes a relevant tool to elucidate involved adaptive pathways. Profiling of volatile metabolites was performed to monitor alterations of bacterial metabolism induced by biosynthesized silver nanoparticles (bio-AgNPs). Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae and Proteus mirabilis were isolated from pressure ulcers, and their cultures were prepared in the presence/absence of bio-AgNPs at 12.5, 25 and 50 µg mL−1. Headspace solid phase microextraction associated to gas chromatography–mass spectrometry was the employed analytical platform. At the lower concentration level, the agent promoted positive modulation of products of fermentation routes and bioactive volatiles, indicating an attempt of bacteria to adapt to an ongoing suppression of cellular respiration. Augmented response of aldehydes and other possible products of lipid oxidative cleavage was noticed for increasing levels of bio-AgNPs. The greatest concentration of agent caused a reduction of 44 to 80% in the variety of compounds found in the control samples. Pathway analysis indicated overall inhibition of amino acids and fatty acids routes. The present assessment may provide a deeper understanding of molecular mechanisms of bio-AgNPs and how the metabolic response of bacteria is untangled. 相似文献
3.
We consider relational structures such that is a set and are two binary relations on . For a number of different classes of structures we show that any structure can be represented as the intersection of its
maximal extensions. Such a property – called extension completeness – can be seen as a generalisation of Szpilrajn's theorem
which states that each partial order is the intersection of its total order extensions. When can be interpreted as causality and as ‘weak’ causality we obtain a model of concurrent histories generalising that based on causal partial orders.
Received 1 February 1994 / 6 May 1996 相似文献
4.
The article proposes an analytical method for determining occupancy distribution and blocking probability in systems which are offered overflow traffic composed of multi-service traffic streams. The described analytical model enables determination of parameters of traffic overflowed from primary groups in hierarchically constructed telecommunication networks. The proposed method is based on an appropriate modification of the Kaufman-Roberts recursion for the full-availability group with multi-rate traffic and uses the modified Fredericks & Hayward’s approximation. Additionally, an approximate method for dimensioning systems with multi-service overflow traffic is also presented. The analytical results of the blocking probability and the results obtained in the dimensioning processes calculated using the presented methodology are compared with the data obtained from the system simulation process. 相似文献
5.
Maciej W. Rogoziski 《Systems & Control Letters》1989,12(5):449-453
An optimal predictor is developed for a singular random process generated by a known system driven by a white noise sequence. The properties of the predictor are compared with those of the optimal predictor for a nonsingular random process. 相似文献
6.
Teresa Mikołajczyk Grażyna Janowska Mariusz Wójcik Maciej Boguń Andrzej Kurzak 《应用聚合物科学杂志》2008,109(4):2513-2521
The rheological properties of spinning solutions of polyacrylonitrile in dimethyl formamide (DMF) containing various amounts of a ferromagnetic nanoaddition were investigated. The porous structure, the strength and thermal properties of fibers obtained from these solutions were assessed, as well as the uniformity of the nanoaddition distribution on the fiber surface was estimated. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008 相似文献
7.
Wiera Oliferuk Andrzej Korbel Maciej W. Grabski 《Materials Science and Engineering: A》1996,220(1-2):123-128
The mechanism of slip and its consequence in the process of energy storage during uniaxial tension of austenitic steel was studied. The interpretation of the energy storage process in terms of the slip development and microscopic shear band formation is presented. 相似文献
8.
The objective of the present work is to further explore the problem of selection of the flow stress function which will give the best agreement with experiments for a wide range of the Zener‐Hollomon parameter. Analysis of various flow stress functions was performed, with particular emphasis on the Zerilli‐Armstrong model. Inverse analysis was successfully applied to identify the flow stress model for microalloyed steels deformed in ferrite, two‐phase and austenite regions. Inverse method is applied to interpret the results of the axisymmetrical compression tests performed for HSLA steel samples on a Gleeble 3800 and Split Hopkinson Pressure Bar. Sensitivity analysis is performed based on local and global methods. The objective of the sensitivity analysis in the present study is the evaluation to what extent the selected coefficients in the rheological model influence the result of simulations. In the considered tests this result is represented by two dependent variables, the load and the shape of the sample (barrelling). It is confirmed that the Zerilli‐Armstrong equations should be applied at very high strain rates. Physical meaning is an advantage of this model. Difficulties with identification are the main disadvantage. 相似文献
9.
Generalized adaptive notch filters with frequency debiasing for tracking of polynomial phase systems
Generalized adaptive notch filters are used for identification/tracking of quasi-periodically varying dynamic systems and can be considered an extension, to the system case, of classical adaptive notch filters. For general patterns of frequency variation the generalized adaptive notch filtering algorithms yield biased frequency estimates. We show that when system frequencies change slowly in a smooth way, the estimation bias can be substantially reduced by means of post-filtering of the frequency estimates. The modified (debiased) algorithm has better tracking capabilities than the original algorithm. 相似文献
10.
Maciej Winiewski Artur Jakubiak Jan Szymanowski 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》1995,63(3):209-214
Decyl isonicotiniate and decyl nicotiniate permit a rapid extraction of palladium(II) from its hydrochloride solutions. Decyl picoliniate is not a suitable extractant. 4-Octylphenylamine can act as a phase transfer catalyst when its concentration in the organic phase is at least 2·5 × 10?4 M . It seems that the interfacial adsorption of pyridine carboxylates and of 4-octylphenylamine is not the decisive phenomenon in palladium(II) extraction. The negligible protonation of the pyridine-type extractants and the phase transfer catalysis explains well the quick extraction of palladium(II) with the commercial and highly hydrophobic extractant ACORGA CLX-50. 相似文献