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Marks L D Ciston J Deng B Rondinelli J 《电子显微学报》2006,25(B08):1-2
Many areas of structure analysis have focused on finding the locations of the atoms. If, instead of the atoms, we knew the positions of the electrons we would in fact know much more, and in most respects knowing where the nuclei are is not important. There is a long history of measurements using precise electron diffraction or X-ray diffraction of the average charge density in materials, but extending beyond to local charge density is, as yet, an unexplored area. 相似文献
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Leonardo Oliveira Bittencourt Victria Santos Chemelo Walessa Alana Bragana Arago Bruna Puty Aline Dionizio Francisco Bruno Teixeira Mileni Silva Fernandes Mrcia Cristina Freitas Silva Luanna Melo Pereira Fernandes Edivaldo Herculano Corrêa de Oliveira Marilia Afonso Rabelo Buzalaf Maria Elena Crespo-Lopez Cristiane do Socorro Ferraz Maia Rafael Rodrigues Lima 《International journal of molecular sciences》2022,23(1)
Mercury is a severe environmental pollutant with neurotoxic effects, especially when exposed for long periods. Although there are several evidences regarding mercury toxicity, little is known about inorganic mercury (IHg) species and cerebellum, one of the main targets of mercury associated with the neurological symptomatology of mercurial poisoning. Besides that, the global proteomic profile assessment is a valuable tool to screen possible biomarkers and elucidate molecular targets of mercury neurotoxicity; however, the literature is still scarce. Thus, this study aimed to investigate the effects of long-term exposure to IHg in adult rats’ cerebellum and explore the modulation of the cerebellar proteome associated with biochemical and functional outcomes, providing evidence, in a translational perspective, of new mercury toxicity targets and possible biomarkers. Fifty-four adult rats were exposed to 0.375 mg/kg of HgCl2 or distilled water for 45 days using intragastric gavage. Then, the motor functions were evaluated by rotarod and inclined plane. The cerebellum was collected to quantify mercury levels, to assess the antioxidant activity against peroxyl radicals (ACAPs), the lipid peroxidation (LPO), the proteomic profile, the cell death nature by cytotoxicity and apoptosis, and the Purkinje cells density. The IHg exposure increased mercury levels in the cerebellum, reducing ACAP and increasing LPO. The proteomic approach revealed a total 419 proteins with different statuses of regulation, associated with different biological processes, such as synaptic signaling, energy metabolism and nervous system development, e.g., all these molecular changes are associated with increased cytotoxicity and apoptosis, with a neurodegenerative pattern on Purkinje cells layer and poor motor coordination and balance. In conclusion, all these findings feature a neurodegenerative process triggered by IHg in the cerebellum that culminated into motor functions deficits, which are associated with several molecular features and may be related to the clinical outcomes of people exposed to the toxicant. 相似文献
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We investigate the effects of local charge defects in HREM imaging, using electron densities calculated by density functional methods. As a model of a planar interface with a local charge defect we use the polar MgO square root (111)-3 x 3R30 degrees surface, which has an additional hole per surface unit cell. A complimentary example, the non-polar MgO (100) surface that has no local charge defect is simulated for comparison. We show that the contrast due to local charge defects is rather high, and suggest that they should be directly observable. 相似文献
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Artificial intelligence approach for high level production of amylase using Rhizopus microsporus var. oligosporus and different agro‐industrial wastes
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Mohammad Masoumi Cleiton Carvalho Silva Igor Anjos Lemos Luis Flavio Gaspar Herculano Hamilton Ferreira Gomes de Abreu 《Journal of Materials Engineering and Performance》2017,26(4):1531-1539
The microstructural and textural evolution was analyzed during rolling at room temperature to obtain detailed information about the failure behavior in HSLA grade-420 steel. Electron backscatter diffraction measurements were carried out in both non-cracked and cracked areas after cold rolling to find a correlation between microstructural parameters (i.e., grain orientation, grain boundary characteristics and Taylor factor) and crack propagation. The results showed that the crack tended to propagate along grains oriented with {001} planes parallel to the normal direction with high Taylor factor value. The special boundaries associated with the {111}, {110} and {221} planes were indicated as crack resistance, while ∑ 5, 13a and 17a, which related to the {001} planes, were crack-susceptible. Transgranular cracking was subjected within grains with high Taylor factor, while mismatch in Taylor factor between neighboring grains could provide an easy path for intergranular crack propagation. 相似文献
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Andrew T. Mulder Nicole A. Benedek James M. Rondinelli Craig J. Fennie 《Advanced functional materials》2013,23(38):4810-4820
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Edson Adriano Vendrusculo Guilherme de Castilho Queiroz Gilberto De Martino Jannuzzi Herculano Xavier da Silva Júnior José Antenor Pomilio 《Energy Efficiency》2009,2(3):271-286
The purpose of this paper was to present the results of a life cycle cost analysis concerning the purchase and operation of
a more efficient popular refrigerator model compared with a baseline design in Brazil. The summarized results may be useful
for organizations working to promote sustainable energy development. This paper specifically focuses on refrigerators, since
their energy consumption is predicted to constitute over 30% of the total average domestic electricity bill in Brazilian households.
If all new Brazilian refrigerators had an energy efficiency at the level consistent with the least life cycle cost of ownership,
it would result in an annual savings of 2.8 billion dollars (US$) in electricity bills, 45 TWh of electricity demand, and
18 Mt of CO2 emissions, with a respective payback period of 7 years which is less than half the average estimated lifetime of a refrigerator.
The analysis was conducted following the guidelines of similar analyses available from the US Department of Energy and the
Collaborative Labeling and Appliance Standards Program.
相似文献
Edson Adriano VendrusculoEmail: |