Isothermal curves and kinetics in a metal hydride

The isotherms for the alloy DB 5800 between — 196 °C (77 K) and 40 °C (313 K) are measured. The pressure range is 0 bar up to 2 bar. A new reactor was developed and constructed for these conditions. An equation to describe the isotherms is derivated. Isotherm measurements are possible at temperatures below 130 °C (143 K). Kinetic measurements are carried out, an equation for the storing rate is derivated, and the kinetic parameters are determined.     

Energy Metabolites as Biomarkers in Ischemic and Dilated Cardiomyopathy

With more than 25 million people affected, heart failure (HF) is a global threat. As energy production pathways are known to play a pivotal role in HF, we sought here to identify key metabolic changes in ischemic- and non-ischemic HF by using a multi-OMICS approach. Serum metabolites and mRNAseq and epigenetic DNA methylation profiles were analyzed from blood and left ventricular heart biopsy specimens of the same individuals. In total we collected serum from n = 82 patients with Dilated Cardiomyopathy (DCM) and n = 51 controls in the screening stage. We identified several metabolites involved in glycolysis and citric acid cycle to be elevated up to 5.7-fold in DCM (p = 1.7 × 10⁻⁶). Interestingly, cardiac mRNA and epigenetic changes of genes encoding rate-limiting enzymes of these pathways could also be found and validated in our second stage of metabolite assessment in n = 52 DCM, n = 39 ischemic HF and n = 57 controls. In conclusion, we identified a new set of metabolomic biomarkers for HF. We were able to identify underlying biological cascades that potentially represent suitable intervention targets.     

A new one-phase material model for the numerical prediction of critical material flow conditions in thixoforging processes

Thixoforging allows one-step forming processes of near-net shape components having excellent mechanical properties. However, the high sensitivity of thixoforging regarding process conditions requires precise modelling and determination of process related parameters. At the same time, simple numerical design proves challenging because of the inaccuracy of existing one-phase material models regarding the shear thinning flow behaviour of semi solid metals. Consequently, this paper deals with the development of a new one-phase material model providing a more precise simulation of materials’ shear rate dependency. By using this model, simulations could be performed, which allowed the prediction of solidification and flow-related component defects.     

Constraint-based and SAT-based diagnosis of automotive configuration problems

We compare the concepts and computation of optimized diagnoses in the context of Boolean constraint based knowledge systems of automotive configuration, namely the preferred minimal diagnosis and the minimum weighted diagnosis. In order to restore the consistency of an over-constrained system w.r.t. a strict total order of the user requirements, the preferred minimal diagnosis tries to keep the most preferred user requirements and can be computed, for example, by the FASTDIAG algorithm. In contrast, partial weighted MinUNSAT solvers aim to find a set of unsatisfied clauses with the minimum sum of weights, such that the diagnosis is of minimum weight. It turns out that both concepts have similarities, i.e., both deliver an optimal minimal correction subset. We show use cases from automotive configuration where optimized diagnoses are desired. We point out theoretical commonalities and prove the reducibility of both concepts to each other, i.e., both problems are FP^NP-complete, which was an open question. In addition to exact algorithms we present greedy algorithms. We evaluate the performance of exact and greedy algorithms on problem instances based on real automotive configuration data from three different German car manufacturers, and we compare the time and quality tradeoff.     

Degradation behavior of novel Fe/ß-TCP composites produced by powder injection molding for cortical bone replacement

When it comes to bone replacement in load-bearing areas, there are currently no adequate biodegradable implants available. Several non-degradable metallic materials fulfill the requirements of biocompatibility and mechanical strength. However, besides magnesium, only iron is a degradable metallic material. The aim of this long-term degradation study was to investigate the effects of iron beta-tricalcium phosphate interpenetrating phase composite on degradation rate and strength in comparison to pure iron. Cylindrical samples with 0–50 vol% beta-tricalcium phosphate (ß-TCP) were prepared by powder injection molding. In addition to dense samples, porous iron samples with a porosity of 60.3 % were produced with polyoxymethylene as a placeholder. Dense and porous samples were immersed in 0.9 % sodium chloride solution (NaCl) or in phosphate buffered saline solution (PBS) for 56 days. Following immersion, the degradation rate, compressive yield strength, and ion release were determined. A maximum degradation rate of 196 µm/year was observed after 56 days for iron with 40 vol% ß-TCP. This was found to be 28 % higher than for pure iron. After immersion, the compressive yield strength of pure iron decreased by 44 % (NaCl) and 48 % (PBS). In comparison, iron with 40 % ß-TCP samples lost <1 % (NaCl) and 9 % (PBS) of strength following immersion. It was demonstrated that the solubility of calcium phosphate enhanced the corrosion processes and led to an increase in degradation, thus showing that the addition of ß-TCP to pure iron can be a promising route for a novel degradable bone substitute material, particularly for load-bearing areas due to the increased strength.     

The influence of the compatibilizer on the morphology and thermal properties of polypropylene‐layered double hydroxide composites

Polypropylene (PP)/layered double hydroxide (LDH) composites were prepared via melt‐compounding using both a carbonate‐LDH and an organo‐LDH (dodecyl benzene sulfonate DBS‐LDH) in different concentrations. Transmission electron microscopy and X‐ray diffraction analysis were used to investigate the morphology. The results showed that only by using DBS‐LDH the intercalation of polymer chains and a partial delamination were obtained. However, the introduction of maleic anhydride‐grafted polypropylene (PP‐g‐MAH), as coupling agent, favored the aggregation of the particles generating localized domains of aggregates. The thermo‐gravimetric analysis showed that PP/DBS‐LDH composites have a higher thermal stability than the pure matrix. Differential scanning calorimetry evidenced that both LDH and DBS‐LDH particles acted as nucleating agents increasing the crystallization temperature, even if, in the case of LDH the effect was observed only with the addition of the compatibilizer. The results collected by dynamic mechanical thermal analysis, beyond showing a significant increase of the matrix stiffness by incorporation of DBS‐LDH, evidenced an increase of the PP glass transition temperature (T_g) indicating a restriction of PP chain segment mobility due to the strong polymer‐particle interactions. POLYM. COMPOS., 2010. © 2009 Society of Plastics Engineers     

Java-basiertes automatisiertes Test-Framework

Java-based Automated Test-Framework With an increasing number of software-systems built using components, software developers are faced with entirely new challenges. For example, testing these modu-lar systems has become far more complex. Manual test approaches are incapable of dealing with the new architectures, leaving several parts of the systems untested. Thorough tests require extensive use of human resources, with enormous financial repercussions. Most customers are unwilling to accept these, completely unaware of their eventual benefit. Even existing automated software test approaches can only remedy these problems in parts. They commonly require source code access to add the necessary test routines, making the approach unsuitable for third party compo-nents. The innovative CBTesten approach tackles this problem. A highly dynamic framework is introduced into the software-system after compilation, which allows de-riving of test cases as well as fully automated tests based on the collected data.