Current-mode A/D converter

The authors report the design of a new current-mode A/D converter, based on a modified successive-approximations model, in 1.2 μm CMOS technology. The proposed circuit is characterised by good accuracy and fast dynamic performance, low power consumption and small occupation area. SPICE simulations allow the design approach to be validated and the electrical performance of the ADC to be predicted     

The influence of semantic encoding on recognition memory in Alzheimer's disease

Within the framework of the distinction between episodic and semantic memory, it has been argued that these two memory systems are organised in a hierarchical way. The hierarchical hypothesis assumes that episodic memory is a specific subsystem of semantic memory and therefore implies that episodic memory cannot exist without semantic memory. If this hypothesis is correct, it should be expected that patients with impaired semantic memory also have impaired episodic memory. In the present study, two experiments investigated the influence of semantic encoding on recognition memory performance in a population of 20 patients with Alzheimer's disease and 18 normal controls. Both experiments assessed recognition memory for semantically-related items. In Experiment 2, but not in Experiment 1, subjects were explicitly instructed to make a semantic association between the items. Alzheimer's disease patients were impaired, compared to the normal controls, on the recognition memory performance of both experiments. The ability to make a semantic association between two items was significantly and positively correlated with the subjects' performance on the recognition tasks. A further analysis showed that patients who were impaired on the semantic association task did significantly worse on the recognition task of Experiment 2 than normal controls and patients who were unimpaired on the semantic association task. These findings are discussed in the context of memory deficits in Alzheimer's disease, and are interpreted as supporting the view that episodic memory for an item is affected by the level of semantic awareness of that same item.     

Non-contact handling in microassembly: Acoustical levitation

Microassembly is currently of the utmost importance in industry. Nevertheless, the classical assembly processes are no longer usable for very small components, typically ranging from 10  m to 10 mm, since usually neglected surface forces disturb the handling task by inducing adhesion between the component and the gripper. A promising alternative to tackle surface forces consists in levitating the handled component. The various advantages of this contactless handling method are reviewed here and justify the choice of this approach. Consequently, the numerous physical principles suitable for contactless handling are briefly described together with their limitations. The evaluation shows that acoustic levitation is best fitted in the case of microassembly. A classification of literature applications is presented hereafter with special focus on acoustic levitation. Finally, the most common models of acoustical levitation are inspected in a general way. The described models come within the scope of non-linear acoustics.     

Analysis of electrocardiograms during atrial fibrillation

The research discussed in this article is motivated by the search for an optimal classification of the different types of atrial fibrillation (AF) on the basis of recorded atrial signals. This would facilitate the selection of an optimal therapy. This article focuses on the biophysical models of the genesis of ECG waveforms during AF. The model of the electric activity of the atria was found to have sufficient realism to be used to describe the electric sources during AF. The inclusion of the volume conduction model resulted in electrocardiographic signals that are in all aspects similar to those observed clinically. The model is currently applied to solve various problems related to optimal signal preprocessing and extraction of features in AF signals for the classification of AF abnormalities. The biophysical model of the atrial activity is an essential element in this research, since it is capable of describing the electric source specifications derived from different hypotheses relating to the etiology of AF     

A theoretical framework for gain scheduling

The weighted incremental norm approach was originally introduced as a natural framework for extending well‐known H_∞ linear control concepts into the nonlinear context. In this paper, we investigate the numerous links between this new approach and the classical gain‐scheduling technique. Although based on heuristic rules, gain‐scheduled control is probably the most widespread nonlinear technique. In this paper, we point out that the control objectives of the gain‐scheduled controller design can be expressed as the weighted incremental norm minimization of a nonlinear operator. The result interest is twofold: it first provides a rigorous mathematical formulation of the gain‐scheduling problem. Furthermore, existing gain‐scheduling techniques can be interpreted as approximate solutions to the weighted incremental norm minimization of a nonlinear operator. Copyright © 2003 John Wiley & Sons, Ltd.     

Drug Release from Lipogels According to Gelling Conditions and Mechanical Treatment

The release rate of a drug dissolved in the liquid phase of lipogels may be greatly affected by the type and concentration of gelling agent and by processing conditions and mechanical treatment of the ointment. These differences in release rate are reduced after application of mechanical stress comparable with the strain exerted on the ointment during application to the skin. Therefore, changes in the concentration of gelling agents used to achieve suitable consistency and manufacturing and packing processes that meet industrial and marketing requirements do not appear to exert a practical influence on drug availability after application to the skin.     

CONTROL OF COKE FORMATION FROM HYDROCRACKED ATHABASCA BITUMEN

The mechanism of formation of carbonaceous deposits from hydrocracked Athabaca bitumen is shown to result in both isotropic and anisotropic solids. The formation of mesophase spheres present as a separate liquid phase has been observed in the laboratory High severity results in the formation of an increased amount of anisotropic solid which is observed in both laboratory and commercial samples. The formation of these deposits in the downstream separators of a commercial plant has occurred and is a hindrance to reliable operation. A strategy to reduce the formation of these deposits in a commercial plant was evaluated in a series of laboratory experiments. The use of process-derived gas oils can be used as quench oil to lower the temperature of the commercial separators. There was no increase in the rate of toluene insoluble formation as a result of the use of quench oils, which allowed the full advantage of the temperature decrease to be achieved. A qualitative comparison of the build-up of deposits in the commercial separators is provided from separator vessel monitoring.