The Role of microRNAs in Development of Colitis-Associated Colorectal Cancer

Colorectal cancer (CRC) is the third most deadly cancer worldwide, and inflammatory bowel disease (IBD) is one of the critical factors in CRC carcinogenesis. IBD is responsible for an unphysiological and sustained chronic inflammation environment favoring the transformation. MicroRNAs (miRNAs) belong to a class of highly conserved short single-stranded segments (18–25 nucleotides) non-coding RNA and have been extensively discussed in both CRC and IBD. However, the role of miRNAs in the development of colitis-associated CRC (CAC) is less clear. The aim of this review is to summarize the major upregulated (miR-18a, miR-19a, miR-21, miR-31, miR-155 and miR-214) and downregulated (miR-124, miR-193a-3p and miR-139-5p) miRNAs in CAC, and their roles in genes’ expression modulation in chronic colonic-inflammation-induced carcinogenesis, including programmed cell-death pathways. These miRNAs dysregulation could be applied for early CAC diagnosis, to predict therapy efficacy and for precision treatment.     

Deep Integration of Innovation and Entrepreneurship (InE) Education in Chinese University Classrooms

Recently, InE has been regarded as a popular education strategy in Chinese universities. However, problems have been exposed in the adoption of InE, for example, in InE courses and competitions. The purpose of this paper is to provide a possible solution to the problems, which is to organize effective InE courses by integrating InE with Inter-Course-level Problem-Based Learning (ICPBL). A detailed case is demonstrated by an ICPBL elective course design with deep integration of InE in the teaching, learning, and assessments. This paper contributes to a new curriculum design for promoting InE education in practically for Chinese universities.     

Effect of Preparation Methods and Condition of Precursors on the Phase Composition of Yttria-Stabilized Zirconia Powders

An yttria-stabilized zirconia powder, free of monoclinic phase, may be prepared by an oxalate method in an ethanol solution at strong acidity. This study demonstrates that the control of pH in the preparation of precursors has a significant effect on the ability of precursors to crystallize and hence plays an important role in determining the formation and fraction of various crystalline phases in the resulting yttria-stabilized zirconia powder. With the increase of pH, a precursor with a certain crystalline form may be transformed into an amorphous precursor, and a monoclinic phase appers in the phase composition of the resulting powder. The results of XRD analysis and Raman spectroscopy are discussed.     

MODELING WATER LOSS DURING FRYING OF POTATO STRIPS: EFFECT OF SOLUTE IMPREGNATION

The effect of solute impregnation on water loss and oil uptake during potato strip frying was studied. Blanched potato strips were impregnated at 25°C by soaking in a solution of sucrose-NaCl-water, 20-5-75% by weight. After rinsing and air drying, strips were deep fried in sunflower oil at 160, 170 and 180°C. A control treatment, consisting of potato strips blanched but not soaked and later air dried was also conducted. Solute impregnation provided a decrease of the oil uptake. Two models, based on Fick's law were used to describe water loss during frying. The first one is the classic model with an effective moisture diffusion coefficient assumed a constant value. The second model considers that diffusion coefficient varies during the frying process. For a given frying temperature, constant diffusion coefficient for control potatoes resulted in lower values than the impregnated ones. The variable diffusivity model showed a two-stage behavior: during the first stage of frying, diffusion coefficient increased with frying temperatures, but from a given time on an inverse behavior began. This last fact was found to be related to an increase of the measured peak force needed to penetrate the potato crust.     

真空蒸馏脱硒的研究

本文从理论上分析了真空蒸馏脱Se的影响因素时间和温度,并通过实验给予验证,提出了最佳条件,对工业采用真空蒸馏脱出含Se物料中的Se具有一定的指导性。     

砼受压损伤力学本构模型的研究

本文利用ＭＴＳ公司８１５．０２型电液伺服试验系统对砼进行了等应变速率加载控制的应力一应变全曲线试验，应用不可逆热力学和内变量理论的成果建立了砼损伤力学模型，并用概率统计的观点分析了损伤的演化规律。由于考虑了不可逆变形的影响，本文所建本构模型与实验吻合较好。     

高等师范院校计算机基础课程教学探讨

分析了计算机基础课程的教学现状,并指出了存在的问题:理论知识与实际操作缺乏紧密结合,学生的综合应用能力较差。以课程建设入手,根据课程的特色及开设目标,构建科学合理的教学内容和知识体系,从理论教学、实践教学及课程考核三方面提出了课程教学的建议,将微格教学、案例教学的思想融入教学体系中,以此提高课堂教学的质量。     

一种基于DSP控制的变电站所用电应急电源快速接入装置研究

变电站所用电采用备用电源时,需要接入应急电源以保证供电安全,现场检修人员接入应急电源的时间需要50 min左右,耗时较长,电路可靠性降低.采用DSP芯片研制了一套变电站所用电应急电源快速接入装置,采用快速傅里叶算法(FFT)对相关电力参数进行跟踪,在备用电源出现问题时可以在3 min之内自动接入应急电源,并可自动通知维修人员,使用方便可靠.该装置已在江苏电网多个变电站投入使用,运行情况稳定.     

A3型李代数的张量积分解

不可约模的张量积分解是李代数表示理论的重要问题,在计算最低双边胞腔上的Kazhdan-Lusztig多项式的首项系数时,有重要的应用.通过李代数中的相关知识和计算机编程,给出了A3型李代数的部分张量积分解的具体表达式,为进一步计算?3型仿射Weyl群最低双边胞腔上的Kazhdan-Lusztig首项系数奠定了基础.