Single photon emission computed tomographic blood flow and magnetic resonance volume imaging of basal ganglia in Huntington''s disease

During oogenesis in Drosophila, germ cells appear in sequential clusters of 16 interconnected cells. The events surrounding the differentiation of these cells are not fully understood. Here we present genetic and morphological analysis of mutations in the gene stand still (stil). Through complementation analyses we have refined the location of this gene to cyological region 49B-C. Our analyses of ovaries from ethylmethane sulfonate (EMS)-induced mutant alleles of this gene suggest that mutations in the stil gene produce a wide range of phenotypic abnormalities, from the absence of germ cells in the most severe alleles, to egg chambers with cytoskeletal defects in the less severe alleles. Our results suggest a role for this gene in specifying or maintaining a cytoskeletal component, with consequences during oogenesis and possibly during germ line sex determination.     

PACAP-38 in Acute ST-Segment Elevation Myocardial Infarction in Humans and Pigs: A Translational Study

Acute myocardial infarction (MI) is one of the most common causes of death worldwide. Pituitary adenylate cyclase activating polypeptide (PACAP) is a cardioprotective neuropeptide expressing its receptors in the cardiovascular system. The aim of our study was to examine tissue PACAP-38 in a translational porcine MI model and plasma PACAP-38 levels in patients with ST-segment elevation myocardial infarction (STEMI). Significantly lower PACAP-38 levels were detected in the non-ischemic region of the left ventricle (LV) in MI heart compared to the ischemic region of MI-LV and also to the Sham-operated LV in porcine MI model. In STEMI patients, plasma PACAP-38 level was significantly higher before percutaneous coronary intervention (PCI) compared to controls, and decreased after PCI. Significant negative correlation was found between plasma PACAP-38 and troponin levels. Furthermore, a significant effect was revealed between plasma PACAP-38, hypertension and HbA1c levels. This was the first study showing significant changes in cardiac tissue PACAP levels in a porcine MI model and plasma PACAP levels in STEMI patients. These results suggest that PACAP, due to its cardioprotective effects, may play a regulatory role in MI and could be a potential biomarker or drug target in MI.     

Modeling of Intercritical Heat Treatment of DP and TRIP Steels

The final microstructure of DP and TRIP assisted steels can evolve after hot working (hot rolling) or during post heat treatment process. In the formation of the final structure a number of different technological parameters have important roles, e.g. end temperature of rolling, cooling rates, temperature of intercritical annealing, etc. As a result of the individual factors and their combinations a lot of product technology routes are feasible. The effect of the different combinations of these technological parameters on the microstructure can be mapped by the special Jominy end-quench test (so called intercritical Jominy end-quench test) described in this paper. Unlike the traditional Jominy test, in this case there is a partial anstenizing between A1 and A3 temperatures which results in a given amount of ferrite in the microstructure before quenching. The method developed can be applied for mapping DP and TRIP assisted steels' microstructure in a wide range of technological parameters. The analysis of measured and calculated data can help us find the technological parameters optimal from the microstructural point of view.     

On Efficiency of Multi-job Grid Allocation Based on Statistical Trace Data

The ever growing number of computation-intensive applications calls for utilizing large-scale, potentially interoperable distributed infrastructures. Nowadays, such distributed systems enable the management of heterogeneous scientific workflows of considerable sizes, where job scheduling and resource management is a crucial issue. In this paper we focus on the challenges of scheduling parameter sweep applications, a specific and commonly used type of workflows where ordering of job executions is irrelevant. A parameter sweep has a large set of independent job instances, called a multi-job, submitted for execution in a single step. In order to cope with the high uncertainty and unpredictable load of resources, and the simultaneous submissions of multi-job instances, we propose a statistics-based brokering approach for allocating jobs to resources so that the makespan is minimised. Earlier studies claim that users’ predictions on job runtime are inaccurate and unusable for scheduling. Our aim is to examine, whether statistical trace data for the same purpose is efficient compared to randomized allocation.     

Degree-constrained decompositions of graphs: Bounded treewidth and planarity

We study the problem of decomposing the vertex set V$V$ of a graph into two nonempty parts _V1,_V2$V_1,V_2$ which induce subgraphs where each vertex v∈_V1$v\in V_1$ has degree at least a(v)$a(v)$ inside _V1$V_1$ and each v∈_V2$v\in V_2$ has degree at least b(v)$b(v)$ inside _V2$V_2$. We give a polynomial-time algorithm for graphs with bounded treewidth which decides if a graph admits a decomposition, and gives such a decomposition if it exists. This result and its variants are then applied to designing polynomial-time approximation schemes for planar graphs where a decomposition does not necessarily exist but the local degree conditions should be met for as many vertices as possible.     

Why Are You Bringing Up Condoms Now? The Effect of Message Content on Framing Effects of Condom Use Messages.

According to prospect theory (A. Tversky & D. Kahneman, 1981), messages advocating a low-risk (i.e., easy, low-cost) behavior are most effective if they stress the benefits of adherence (gain framed), whereas messages advocating a risky behavior are most effective if they stress the costs of nonadherence (loss framed). Although condom use is viewed as a low-risk behavior, it may entail risky interpersonal negotiations. Study 1 (N = 167) compared ratings of condom use messages advocating relational behaviors (e.g., discussing condoms) or health behaviors (e.g., carrying condoms). As predicted, loss-framed relational messages and gain-framed health messages received higher evaluations. Study 2 (N = 225) offers a replication and evidence of issue involvement and gender as moderators. Results are discussed with reference to the design of condom use messages. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Characterizing Grids: Attributes, Definitions, and Formalisms

Grid systems and technologies have evolved over nearly a decade; yet, there is still no widely accepted definition for Grids. In particular, the essential attributes that distinguish Grids from other distributed computing environments have not been articulated. Most approaches to definition adopt a static view and consider only the properties and components of, or the applications supported by, Grids. The definition proposed in this paper is based on the runtime semantics of distributed systems. Rather than attempt to simply compare static characteristics of Grids and other distributed computing environments, this paper analyzes operational differences, from the viewpoint of an application executing in both environments. Our definition is expressed formally as an Abstract State Machine that facilitates the analysis of existing Grid systems or the design of new ones with rigor and precision. This new, semantical approach proposes an alternative to the currently accepted models for determining whether or not a distributed system is a Grid.