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排序方式: 共有2868条查询结果,搜索用时 15 毫秒
1.
Virginija Sacevičienė Milda Jucienė Vaida Dobilaitė Valentina Krylova Skirma Žalenkienė Nijolė Dukštienė Raimondas Bliūdžius 《应用聚合物科学杂志》2019,136(21):47523
The aim of this work was to investigate the physical and mechanical performance of architectural polyester (PES)–poly(vinyl chloride) (PVC) membranes exposed to different artificial aging conditions. Two commercially available architectural membranes were chosen as research objects. The durability of the PES/PVC fabrics was evaluated by the loss in mechanical performance, scanning electron microscopy, and X-ray diffraction analysis in order to understand the effect of the degradation agents on the surface of the membranes. The mechanical performance of the PES/PVC membranes was unchanged. Scanning electron microscopy images of the tested materials showed initial cracks after aging. The X-ray fluorescence analysis showed that at the time of aging, the amount of Cl and Si decreased slightly, while Ti decreased by half, and Ca by volume increased twice. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136, 47523. 相似文献
2.
3.
Ilaria Fraudentali Renato A. Rodrigues-Pousada Riccardo Angelini Sandip A. Ghuge Alessandra Cona 《International journal of molecular sciences》2021,22(10)
Polyamines are ubiquitous, low-molecular-weight aliphatic compounds, present in living organisms and essential for cell growth and differentiation. Copper amine oxidases (CuAOs) oxidize polyamines to aminoaldehydes releasing ammonium and hydrogen peroxide, which participates in the complex network of reactive oxygen species acting as signaling molecules involved in responses to biotic and abiotic stresses. CuAOs have been identified and characterized in different plant species, but the most extensive study on a CuAO gene family has been carried out in Arabidopsis thaliana. Growing attention has been devoted in the last years to the investigation of the CuAO expression pattern during development and in response to an array of stress and stress-related hormones, events in which recent studies have highlighted CuAOs to play a key role by modulation of a multilevel phenotypic plasticity expression. In this review, the attention will be focused on the involvement of different AtCuAOs in the IAA/JA/ABA signal transduction pathways which mediate stress-induced phenotypic plasticity events. 相似文献
4.
Davide De Biase Giuseppe Piegari Francesco Prisco Ilaria Cimmino Ilaria dAquino Valeria Baldassarre Francesco Oriente Serenella Papparella Orlando Paciello 《International journal of molecular sciences》2021,22(7)
Sarcopenia is defined as the age-related loss of skeletal muscle mass, quality, and strength. The pathophysiological mechanisms underlying sarcopenia are still not completely understood. The aim of this work was to evaluate, for the first time, the expression of NLRP3 inflammasome in bovine skeletal muscle in order to investigate the hypothesis that inflammasome activation may trigger and sustain a pro-inflammatory environment leading to sarcopenia. Samples of skeletal muscle were collected from 60 cattle belonging to three age-based groups. Morphologic, immunohistochemical and molecular analysis were performed to assess the presence of age-related pathologic changes and chronic inflammation, the expression of NLRP3 inflammasome and to determine the levels of interleukin-1β, interleukin-18 and tumor necrosis factor alpha in muscle tissue. Our results revealed the presence of morphologic sarcopenia hallmark, chronic lymphocytic inflammation and a type II fibers-selective NLRP3 expression associated to a significant decreased number of immunolabeled-fibers in aged animals. Moreover, we found a statistically significant age-related increase of pro-inflammatory cytokines such as interleukin-1β and interleukin-18 suggesting the activation of NLRP3 inflammasome. Taken together, our data suggest that NLRP3 inflammasome components may be normally expressed in skeletal muscle, but its priming and activation during aging may contribute to enhance a pro-inflammatory environment altering normal muscular anabolism and metabolism. 相似文献
5.
Adele Boccuto Filippo Dragoni Francesca Picarazzi Alessia Lai Carla Della Ventura Carla Veo Federica Giammarino Francesco Saladini Gianguglielmo Zehender Maurizio Zazzi Mattia Mori Ilaria Vicenti 《International journal of molecular sciences》2021,22(5)
The nucleotide analog sofosbuvir, licensed for the treatment of hepatitis C, recently revealed activity against the Zika virus (ZIKV) in vitro and in animal models. However, the ZIKV genetic barrier to sofosbuvir has not yet been characterized. In this study, in vitro selection experiments were performed in infected human hepatoma cell lines. Increasing drug pressure significantly delayed viral breakthrough (p = 0.029). A double mutant in the NS5 gene (V360L/V607I) emerged in 3 independent experiments at 40–80 µM sofosbuvir resulting in a 3.9 ± 0.9-fold half- maximal inhibitory concentration (IC50) shift with respect to the wild type (WT) virus. A triple mutant (C269Y/V360L/V607I), detected in one experiment at 80 µM, conferred a 6.8-fold IC50 shift with respect to the WT. Molecular dynamics simulations confirmed that the double mutant V360L/V607I impacts the binding mode of sofosbuvir, supporting its role in sofosbuvir resistance. Due to the distance from the catalytic site and to the lack of reliable structural data, the contribution of C269Y was not investigated in silico. By a combination of sequence analysis, phenotypic susceptibility testing, and molecular modeling, we characterized a double ZIKV NS5 mutant with decreased sofosbuvir susceptibility. These data add important information to the profile of sofosbuvir as a possible lead for anti-ZIKV drug development. 相似文献
6.
Frédéric Gaschet 《Papers in Regional Science》2002,81(1):63-81
This article examines the relationships between the employment suburbanisation from central cities towards their suburbs,
and the process of intra-urban specialisation that occurred simultaneously in the fifty largest French metropolitan areas.
A methodology is proposed to identify urban subcentres and to analyse the effects of the intra-urban specialisations on suburbanisation
patterns. We conclude that the specialisation of both subcentres and central cities has a significant effect on suburbanisation
rates. Lastly, an intra-metropolitan shift/share analysis provides additional insights into the employment dynamics of central
cities and suburbs during the last twenty years.
Received: 25 July 2000 / Accepted: 29 May 2001 相似文献
7.
We propose an on-line learning algorithm for Multi Layered Perceptrons (MLP) with an Orthogonal Weight Estimator (OWE) architecture. Such an architecture allows to dynamically and efficiently estimate the weights of a MLP in context dependent behaviour problems. The proposed learning algorithm attempts to solve the problem of time-consuming in the learning phase encountered to train these weight estimators. 相似文献
8.
Frédéric Debode Eric Janssen Gilbert Berben 《European Food Research and Technology》2007,226(1-2):273-280
In this paper, four different physical treatments (microwaves, heating by conduction, sonication and pressure autoclaving)
were performed to degrade a pure DNA extract, and their influence on GMO quantification was studied. The aim was to check
the hypothesis that processing of agrofood products results in a similar degradation rate for both the transgenic target and
the specific target. Indeed we could observe that even if the used physical treatments could lead to a significant increase
of C
t values for both transgenic and specific targets, the resulting ΔC
t remained stable. So, the main conclusion of the study is that the aforementioned hypothesis seems valid and thus a physical
degradation of DNA will not affect the relative quantitation of the GMO content, provided that both the specific and transgenic
targets have very similar size. A second important issue of the experiments performed was that DNA is a very robust molecule
as it is extremely difficult to reach a mean size below 100 bp. The study also gives evidence of the importance of using small
targets. 相似文献
9.
Effect of melt spinning on the microstructure and mechanical properties of three Ni-base superalloys
A microstructural and mechanical analysis was performed on three rapidly solidified nickel base superalloys. Transmission
and scanning electron microscopy along with tensile tests were performed on the ribbons in the as-cast and aged condition.
This investigation permitted a correlation to be made between cooling rate, microstructure, and mechanical properties. It
was found that melt spinning significantly altered the physical characteristics of the alloys studied. The rapid cooling rates
(∼107 K/s) produced ribbons with a low dislocation density and small (∼1 μm) low angle cells. The precipitation of γ′ was suppressed,
producing alloys with a smaller volume fraction of precipitates and lower APBE than in the conventionally cast condition.
Also, the matrix/precipitate lattice mismatch was higher in the melt spun foils. Tensile strengths were similar to those in
the conventional form; however, no measurable ductility was present. Aging the ribbons resulted in increases in γ′ volume
fraction, tensile strengths, APBE, and elongations compared to the as-cast ribbons. The results of this work suggest that
many of the microstructural refinements produced by melt spinning are lost after a short aging time at moderate temperatures. 相似文献
10.
Floccia Caroline; Goslin Jeremy; Girard Frédérique; Konopczynski Gabrielle 《Canadian Metallurgical Quarterly》2006,32(5):1276
The processing costs involved in regional accent normalization were evaluated by measuring differences in lexical decision latencies for targets placed at the end of sentences with different French regional accents. Over a series of 6 experiments, the authors examined the time course of comprehension disruption by manipulating the duration and presentation conditions of accented speech. Taken together, the findings of these experiments indicate that regional accent normalization involves a short-term adjustment mechanism that develops as a certain amount of accented signal is available, resulting in a temporary perturbation in speech processing. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献