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排序方式: 共有92条查询结果,搜索用时 31 毫秒
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Filip Hromcik Jan Vokurka Michal Kyr Lydie Izakovicova Holla 《European Journal of Lipid Science and Technology》2021,123(2):2000259
The topical application of aspirin and omega-3 polyunsaturated fatty acids (PUFAs) may trigger the resolution of inflammation by inducing the biosynthesis of pro-resolvers such as lipoxins and resolvins while also avoiding the side effects of systemic aspirin intake. This study assessed the effect of enhanced granulation tissue (EGT) on periodontal tissue regeneration through the local application of aspirin and omega-3 PUFAs directly to granulation tissue (GT) during periodontal surgery. This randomized controlled experiment assesses 38 pockets in 19 patients. In every patient, two similar intrabony periodontal defects are treated with an open flap debridement, one with EGT (GT extracted, enhanced with aspirin and omega-3 PUFAs, and replaced) and the other with standard GT removal. Clinical attachment level (CAL) and probing pocket depth (PPD) are assessed at baseline and 2 and 6 months after surgery. The experimental protocol (EGT) results in a greater CAL gain as compared to that in the controls at 6 months (p < 0.05), while PPD reduction is not affected. The retained GT does not compromise healing. EGT is proposed as a promising, inexpensive, and simple method that may improve the outcome of periodontal regenerative treatment. However, the described protocol requires optimization and further assessment. Practical Applications : The biosynthesis of mediators including resolvins and lipoxins triggered by aspirin and omega-3 PUFAs promote the resolution of inflammation, eventually leading to faster regeneration of inflamed tissues. While granulation tissue is a necessary component in wound healing, enhancing granulation tissue with aspirin and omega-3 PUFAs results in CAL gain in the surgical treatment of periodontal defects. Retained granulation tissue does not compromise periodontal healing. The EGT strategy is an inexpensive and simple method that may improve the clinical outcomes of regenerative periodontal procedures. 相似文献
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L. Valade I. Malfant A. Glaria J.-F. Lamère B. Garreau de Bonneval D. de Caro S. Vincendeau K. Jacob M.-L. Doublet A. Zwick 《Journal of Low Temperature Physics》2006,142(3-4):449-452
For the development of new crystal and electronic structures in molecular conductors, dimeric tetrathiafulvalene (TTF) and
tetraselenafulvalenes (TSFs)1–3 linked by single or double methyl antimony bridge(s) have been prepared and their neutral crystal structures have been investigated.
The donor2 (cis-2) forms a metallic cation radical salt with tetracyanoquinodimethane (TCNQ) containing one-dimensional array interactions. 相似文献
5.
Lydie du Bousquet Masahide Nakamura Ben Yan Hiroshi Igaki 《Innovations in Systems and Software Engineering》2009,5(3):181-196
A home network system consists of multiple networked appliances, intended to provide more convenient and comfortable living
for home users. Before being deployed, one has to guarantee the correctness, the safety, and the security of the system. Here,
we present the approach chosen to validate the Java implementation of a home network system. We rely on the Java Modelling
Language to formally specify and validate an abstraction of the system.
This is a substantially revised version of our paper that appeared in the proceedings of the Workshop On Leveraging Applications
of Formal Methods, Verification and Validation (ISoLA), Poitiers-Futuroscope, France, December 2007. 相似文献
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Discovery of Heterocyclic Nonacetamide Synaptic Vesicle Protein 2A (SV2A) Ligands with Single‐Digit Nanomolar Potency: Opening Avenues towards the First SV2A Positron Emission Tomography (PET) Ligands 下载免费PDF全文
Joël Mercier Laurence Archen Véronique Bollu Stéphane Carré Yves Evrard Dr. Eric Jnoff Dr. Benoît Kenda Bénédicte Lallemand Dr. Philippe Michel Dr. Florian Montel Dr. Florence Moureau Nathalie Price Dr. Yannick Quesnel Dr. Xavier Sauvage Dr. Anne Valade Dr. Laurent Provins 《ChemMedChem》2014,9(4):693-698
The role of the synaptic vesicle protein 2A (SV2A) protein, target of the antiepileptic drug levetiracetam, is still mostly unknown. Considering its potential to provide in vivo functional insights into the role of SV2A in epileptic patients, the development of an SV2A positron emission tomography (PET) tracer has been undertaken. Using a 3D pharmacophore model based on close analogues of levetiracetam, we report the rationale design of three heterocyclic non‐acetamide lead compounds, UCB‐A, UCB‐H and UCB‐J, the first single‐digit nanomolar SV2A ligands with suitable properties for development as PET tracers. 相似文献
8.
Ccile Coudy-Gandilhon Marine Gueugneau Christophe Chambon Daniel Taillandier Lydie Combaret Ccile Polge Guillaume Y. Millet Lonard Fasson Daniel Bchet 《International journal of molecular sciences》2022,23(7)
Middle-aged and master endurance athletes exhibit similar physical performance and long-term muscle adaptation to aerobic exercise. Nevertheless, we hypothesized that the short-term plasticity of the skeletal muscle might be distinctly altered for master athletes when they are challenged by a single bout of prolonged moderate-intensity exercise. Six middle-aged (37Y) and five older (50Y) master highly-trained athletes performed a 24-h treadmill run (24TR). Vastus lateralis muscle biopsies were collected before and after the run and assessed for proteomics, fiber morphometry, intramyocellular lipid droplets (LD), mitochondrial oxidative activity, extracellular matrix (ECM), and micro-vascularisation. Before 24TR, muscle fiber type morphometry, intramyocellular LD, oxidative activity, ECM and micro-vascularisation were similar between master and middle-aged runners. For 37Y runners, 24TR was associated with ECM thickening, increased capillary-to-fiber interface, and an 89% depletion of LD in type-I fibers. In contrast, for 50Y runners, 24TR did not alter ECM and capillarization and poorly depleted LDs. Moreover, an impaired succinate dehydrogenase activity and functional class scoring of proteomes suggested reduced oxidative phosphorylation post-24TR exclusively in 50Y muscle. Collectively, our data support that middle-aged and master endurance athletes exhibit distinct transient plasticity in response to a single bout of ultra-endurance exercise, which may constitute early signs of muscle aging for master athletes. 相似文献
9.
Marine Milard Fabienne Laugerette Annie Durand Charline Buisson Emmanuelle Meugnier Emmanuelle Loizon Corinne Louche‐Pelissier Valrie Sauvinet Lorna Garnier Sbastien Viel Karne Bertrand Florent Joffre David Cheillan Lydie Humbert Dominique Rainteau Pascale Plaisanci Laure B. Bindels Audrey M. Neyrinck Nathalie M. Delzenne Marie‐Caroline Michalski 《Molecular nutrition & food research》2019,63(4)
10.
Christophe Faulmann Stéphane Dorbes José A. Real Lydie Valade 《Journal of Low Temperature Physics》2006,142(3-4):261-266
The synthesis, structure, magnetic behavior and electrical conductivity of the system [Fe(sal2trien)][Ni(dmit)2]x have been investigated. The electrocrystallization method used has afforded small amounts of crystalline multi-phase materials.
In particular, the complex salt [Fe(sal2trien)][Ni(dmit)2]3 has been unambiguously characterized. Surprisingly, despite it contains the spin crossover cation [Fe(sal2trien)]+, the complex does not exhibit spin transition. Most probably, this fact is related to the structural arrangement of the cationic
species, which in addition are strongly disordered. This salt behaves like a semiconductor. A strongly cooperative spin transition
accompanied with a hysteresis loop is observed in a still-unknown phase obtained during the preparation of [Fe(sal2-trien)] [Ni(dmit)2]3. 相似文献