全文获取类型
收费全文 | 1851篇 |
免费 | 84篇 |
国内免费 | 2篇 |
专业分类
电工技术 | 22篇 |
化学工业 | 482篇 |
金属工艺 | 32篇 |
机械仪表 | 45篇 |
建筑科学 | 40篇 |
矿业工程 | 5篇 |
能源动力 | 60篇 |
轻工业 | 216篇 |
水利工程 | 29篇 |
石油天然气 | 8篇 |
无线电 | 125篇 |
一般工业技术 | 262篇 |
冶金工业 | 161篇 |
原子能技术 | 6篇 |
自动化技术 | 444篇 |
出版年
2024年 | 5篇 |
2023年 | 14篇 |
2022年 | 51篇 |
2021年 | 80篇 |
2020年 | 45篇 |
2019年 | 52篇 |
2018年 | 59篇 |
2017年 | 53篇 |
2016年 | 57篇 |
2015年 | 48篇 |
2014年 | 66篇 |
2013年 | 137篇 |
2012年 | 110篇 |
2011年 | 138篇 |
2010年 | 100篇 |
2009年 | 104篇 |
2008年 | 89篇 |
2007年 | 77篇 |
2006年 | 74篇 |
2005年 | 58篇 |
2004年 | 54篇 |
2003年 | 45篇 |
2002年 | 43篇 |
2001年 | 35篇 |
2000年 | 15篇 |
1999年 | 27篇 |
1998年 | 32篇 |
1997年 | 24篇 |
1996年 | 19篇 |
1995年 | 22篇 |
1994年 | 9篇 |
1993年 | 20篇 |
1992年 | 9篇 |
1991年 | 9篇 |
1990年 | 8篇 |
1989年 | 7篇 |
1988年 | 8篇 |
1985年 | 7篇 |
1984年 | 9篇 |
1983年 | 9篇 |
1982年 | 8篇 |
1981年 | 18篇 |
1979年 | 5篇 |
1978年 | 5篇 |
1977年 | 6篇 |
1976年 | 8篇 |
1971年 | 6篇 |
1970年 | 4篇 |
1966年 | 4篇 |
1936年 | 4篇 |
排序方式: 共有1937条查询结果,搜索用时 15 毫秒
1.
Three-dimensional models, or pharmacophores, describing Euclidean constraints on the location on small molecules of functional
groups (like hydrophobic groups, hydrogen acceptors and donors, etc.), are often used in drug design to describe the medicinal
activity of potential drugs (or ‘ligands’). This medicinal activity is produced by interaction of the functional groups on
the ligand with a binding site on a target protein. In identifying structure-activity relations of this kind there are three
principal issues: (1) It is often difficult to “align” the ligands in order to identify common structural properties that
may be responsible for activity; (2) Ligands in solution can adopt different shapes (or `conformations’) arising from torsional
rotations about bonds. The 3-D molecular substructure is typically sought on one or more low-energy conformers; and (3) Pharmacophore
models must, ideally, predict medicinal activity on some quantitative scale. It has been shown that the logical representation
adopted by Inductive Logic Programming (ILP) naturally resolves many of the difficulties associated with the alignment and
multi-conformation issues. However, the predictions of models constructed by ILP have hitherto only been nominal, predicting
medicinal activity to be present or absent. In this paper, we investigate the construction of two kinds of quantitative pharmacophoric
models with ILP: (a) Models that predict the probability that a ligand is “active”; and (b) Models that predict the actual
medicinal activity of a ligand. Quantitative predictions are obtained by the utilising the following statistical procedures
as background knowledge: logistic regression and naive Bayes, for probability prediction; linear and kernel regression, for
activity prediction. The multi-conformation issue and, more generally, the relational representation used by ILP results in
some special difficulties in the use of any statistical procedure. We present the principal issues and some solutions. Specifically,
using data on the inhibition of the protease Thermolysin, we demonstrate that it is possible for an ILP program to construct
good quantitative structure-activity models. We also comment on the relationship of this work to other recent developments
in statistical relational learning.
Editors: Tamás Horváth and Akihiro Yamamoto 相似文献
2.
Abstract: This paper describes a shell for cooperating expert systems that has been developed at the University of Porto. The main goal of this shell is two-fold: to generate a community of cooperative knowledge-based systems and to develop several special reasoning techniques which can be used under a distributed and cooperative paradigm. UPShell is able to convert a set of generated intelligent systems (ISs) into a community of cooperative ISs. In this first version it is already possible to generate different intelligent systems which are able to run 'simultaneously' as separate Unix processes and, using a message-passing mechanism, to communicate among themselves. They can be set to pursue an overall goal in a cooperative way. Moreover, several tasks can be given to each IS to be solved simultaneously, and the IS can switch from task to task according to dynamic priorities reflecting the urgency attached to the specific sub-tasks that emerge. The shell described here may also be used to test, within a distributed environment, some time-bounded reasoning techniques that are presently being developed. The paper has three main parts: a general overview of the UPShell (Section 1); a tutorial explaining, by means of examples, how to use the package (Section 2); and, finally, some considerations on the reasoning techniques used and future improvements (Sections 3–5). 相似文献
3.
Mirna Suárez-Quiroz Béatrice De Louise Oscar Gonzalez-Rios Michel Barel Bernard Guyot Sabine Schorr-Galindo & Joseph-Pierre Guiraud 《International Journal of Food Science & Technology》2005,40(6):605-611
Roasting coffee led to a drop in the ochratoxin A (OTA) concentration, as measured by the reference method, especially for dark type roasts. The way the beverage was prepared also affected the OTA content, which could paradoxically be higher than that of the initial roasted coffee. Assays on the thermal stability of pure OTA showed that it ought to be found in larger quantities in roasted coffee. This suggested that OTA was masked by reactions with the substrate during roasting. The absence of OTA in green coffee is therefore the best guarantee of safety. 相似文献
4.
Thermal treatment applied in association with a biological system allows for a significant reduction in excess sludge production (approximately 50%). In general, heat treatment is described as a sludge disintegration technique. This paper offers a thorough study on the impact of heat treatment, at temperatures below 100 degrees C, on the solubilisation of the sludge COD and its biodegradability. Discontinuous heating experiments were performed on activated and digested sludge. At all temperatures tested the released COD for digested sludge was systematically higher than that for activated sludge (15 and 40%, respectively, at 95 degrees C for 40 min of contact time). For the first 30 min, a 1st order kinetic, with respect to the residual COD, was systematically found. In the range of 40-95 degrees C, digested sludge had a lower activation energy than activated sludge (26 kcal/mol compared to 70-160 kcal/mol). COD solubilisation is thus more positively influenced by temperature in the case of activated sludge. This may be due to the significant difference in the ratio of protein/carbohydrate in digested and activated sludge (1-5 and 0.2-0.7, respectively). The increase in the COD/TKN ratio in the solubilised fraction after thermal treatment of activated sludge suggests a preferential solubilisation of proteins over carbohydrates. Respirometric tests performed on the solubilised COD showed that whatever the sludge origin, only 40-50% of released COD is biodegradable at a conventional hydraulic retention time (i.e., 24 h). Hence, heat treatment would act more through organic matter solubilisation rather than by a biodegradability increase. 相似文献
5.
Camacho Christopher J.; Higgins E. Tory; Luger Lindsay 《Canadian Metallurgical Quarterly》2003,84(3):498
People experience regulatory fit (E. T. Higgins, 2000) when the strategic manner of their goal pursuit suits their regulatory orientation, and this regulatory fit feels right. Fit violation feels wrong. Four studies tested the proposal that experiences of fit can transfer to moral evaluations. The authors examined transfer of feeling wrong from fit violation by having participants in a promotion or prevention focus recall transgressions of commission or omission (Studies 1 and 2). Both studies found that when the type of transgression was a fit violation, participants expressed more guilt. Studies 3 and 4 examined transfer of feeling right from regulatory fit. Participants evaluated conflict resolutions (Study 3) and public policies (Study 4) as more right when the means pursued had fit. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
6.
7.
O Prez‐Camacho S Sepúlveda‐Guzmn M Prez‐lvarez M García‐Zamora G Cadenas‐Pliego 《Polymer International》2005,54(12):1626-1631
New functionalized styrene–maleimide copolymers were prepared by free radical copolymerization of styrene (St) and N‐4‐carboxybutylmaleimide (NBMI) in chloroform, using 2,2′‐azobisisobutyronitrile (AIBN) as initiator. Monomer and copolymer characterization was carried out by 1H‐ and 13C‐NMR. Copolymer composition was determined by elemental analysis and Fourier‐transform infrared (FTIR) spectroscopy. The glass transition temperature (from DSC) and the thermogravimetric analysis (TGA) of the copolymers were consistent with the thermal behavior and stability observed for alternating St–maleimide copolymers. St–NBMI copolymers crosslinked with divinylbenzene (DVB) were also synthesized and their cation exchange properties evaluated in order to assess the capacity of the new copolymers to bind metallic ions. Copyright © 2005 Society of Chemical Industry 相似文献
8.
Corner detection by local histograms of contour chain code 总被引:4,自引:0,他引:4
9.
10.
The rising of droplets in water contaminated with two surfactants, sodium salt dodecylhydrogenosulphate (L.S.S.) and Teepol, in the range 200 < NRep < 1000 was studied. The dispersed phases used were cyclohexane, benzene, toluene, and n-heptane. Experiences were conducted at a constant temperature of 30°C. It was shown that the presence of the two agents decreases the final rising rate of the droplets with an increasing surfactant concentration and droplet diameter. For the same interfacial tension values, this phenomenon is enhanced in the case of Teepol. An equation is proposed for the computation of the critical droplet diameter as well as the droplet rising rate. These equations demonstrate the effect of the chemical nature of the surface agent and reproduce the experimental results with variations less than 10%. 相似文献