薄板AA2024铝合金无针搅拌摩擦焊搭接工艺与接头性能

文中研究了2024薄板铝合金无针搅拌摩擦搭接接头形貌及力学性能,分析了工艺参数对接头成形与力学性能的影响.结果表明,工艺参数对接头成形及力学性能影响显著.接头中Hook缺陷对接头性能影响较大.当旋转速度一定时,焊接速度的增大使得焊核深度减小,Hook缺陷尖端趋于圆滑过渡,接头的拉剪强度随之增大.当焊接速度一定时,随着旋转速度的增大,焊核深度先增大后减小,Hook缺陷尖端上翘的严重程度先加重后减弱,拉剪强度先降低后增加.搭接接头上下两板的横向显微硬度曲线都近似"W"形分布,最低值出现在上板的热影响区.     

An ultra-high pressure sensor with cylinder structure

Based on strain-resistance effect, an ultra-high pressure sensor has been developed with the range of 0–500 MPa. It is mainly composed of the elastic element and sensitive element. This sensor’s range is determined by the elastic element’s structure and material. In order to endure the ultra-high pressure, the elastic element’s material is selected as spring steel, and its structures are analyzed and simulated. After that, the metal strain gauge as the sensitive element is packaged on the elastic element. Then the sensor is developed after some compensation processes are carried out. In the end, the sensor is calibrated. The results show that the sensor has good performance, such as the accuracy of 0.35%FS, which meets the requirements of aerospace, weapons and other fields.     

尾部扩散器对某跑车气动性能的影响

以某跑车模型为研究对象,探讨尾部小型扩散器对于车身气动性能的影响。在初始模型的基础上,进行CFD(Computational Fluid Dynamics)数值模拟计算,并对比风洞试验数据,验证仿真的可靠性。对初始模型的扩散器进行改进设计,加大扩散器的工作区域,研究其对于气动力的影响,并将改进后的扩散器与带有仿生凹坑型非光滑扰流器结合起来,通过数值模拟方法,得出压力和速度等流场参数,比较不同形式的扩散器对于气动性能的改进效果,分析气动力改善的原因。结果表明:通过对扩散器与非光滑扰流器的优化组合,能有效地提高气动负升力,减小气动阻力,达到了调谐车辆气动升力与气动阻力之间的耦合关系的目的。     

TA15钛合金热挤压过程中金属变形行为及组织分析

运用MSC.Marc有限元软件对TA15钛合金热挤压变形过程进行有限元模拟,得到热挤压成形过程中应力场和应变场分布情况。对有限元模拟所得到的应力、应变数据进行后处理,利用应力偏量不变量J2进行变形分区,采用罗德系数对塑性区内材料的应变类型进行划分。结合有限元模拟结果以及变形分区和变形类型的划分,对热挤压实验后的试样进行组织取样,在不同温度条件下对试样进行微观组织观察,分析微观组织的演化规律,这对于分析金属挤压成形问题及其在实际中的应用具有重要意义。     

合成氨低压联醇系统开车技术总结

简述了100 kt/a低压联醇系统的甲醇合成原理、工艺流程、催化剂升温还原、轻负荷生产及正常生产情况。通过加强工艺控制和及时采取措施处理非正常工况,使低压联醇系统各项工艺指标均达到了设计要求,吨醇可副产蒸汽1.2 t以上。     

农药控释水凝胶的研究进展

水凝胶具有独特三维网络结构,可以容纳大量的水和流体物质,所以被广泛应用于农药控释领域.与合成材料相比,天然高分子材料具有可生物降解、环境友好、经济易得等优点,因此大量被用于水凝胶制备.综述了目前几种常见的天然农药控释水凝胶的研究进展,同时对农药控释水凝胶的发展前景进行了展望.     

Targeted Nanoparticle‐Mediated Gene Therapy Mimics Oncolytic Virus for Effective Melanoma Treatment

Oncolytic virus has potential applications in cancer therapy. However, its clinical application is restricted by the virus‐associated biosafety issues. Here, inspired by the key role of vesicular stomatitis virus matrix protein (VSVMP) in the oncolytic vesicular stomatitis virus (VSV) induced apoptosis, a targeted nanoparticle‐delivered neutral VSVMP gene formulation is designed to act like the VSV for cancer therapy. This VSVMP formulation consists of a CRGDKGPDC peptide modified hybrid monomethoxy poly (ethylene glycol)‐poly(d ,l ‐lactide) nanoparticles complexed with VSVMP plasmid, having good blood compatibility and tumor targeting ability. The transfection efficiency is as high as that of VSV. After intravenous administration, the VSVMP formulation can efficiently target the tumor, significantly inhibit the melanoma growth and metastasis, prolong the survival time of tumor‐bearing mice, and does not cause obvious systemic toxicity. The anticancer mechanisms involve apoptosis induction, angiogenesis inhibition and some virus‐associated signal pathways activation. This work demonstrates a VSV‐inspired nonviral gene therapy that has promising clinical applications in melanoma treatment.     

Nanoparticles targeting tumor-associated macrophages:A novel anti-tumor therapy

The immunosuppressive tumor microenvironment(TME)is crucial in the occurrence of tumorigenesis,metastasis,and drug resistance.Among all stromal cells,tumor-asso...