False rape allegations

With the cooperation of the police agency of a small metropolitan community, 45 consecutive, disposed, false rape allegations covering a 9 year period were studied. These false rape allegations constitute 41% the total forcible rape cases (n = 109) reported during this period. These false allegations appear to serve three major functions for the complainants: providing an alibi, seeking revenge, and obtaining sympathy and attention. False rape allegations are not the consequence of a gender-linked aberration, as frequently claimed, but reflect impulsive and desperate efforts to cope with personal and social stress situations.     

Analytical HFET $I$– $V$ Model in Presence of Current Collapse

A compact analytical model of short-channel AlGaN/GaN HEMTs in the presence of a current collapse is presented. The model is based on an experimentally established trapping mechanism at the gate edges and relies on significant differences between the characteristic carrier capture-escape times and typical RF signal periods. For the first time, we implement the theory describing electric field distributions in the HEMT gate-to-drain spacing region, with and without trapped charge distributions. By consequently accounting for velocity saturation effects in gated and trapped regions of the device, the presented model shows good agreement with the experimental data. The model uses a minimal number of fitting parameters, most of which are physical parameters describing velocity-field dependence of the carriers.     

Discovery of 4-benzylamino-substituted α-carbolines as a novel class of receptor tyrosine kinase inhibitors

Within the last decade, interest in the development of new anticancer drugs increased mainly from emerging resistance against established drugs, which were found to be limited by the multidrug resistance (MDR) phenomenon. Several anticancer targets have been investigated for the development of structurally new drugs which were thought to be unaffected by the MDR phenomenon. Receptor tyrosine kinases (RTKs) make up one interesting group of anticancer targets. The overexpression and mutation of RTKs lead to an ongoing stimulus of cell growth and cancer progression. Early approaches to selective inhibition of single RTKs were generally disappointing in clinical studies, due in part to occurring resistance. Therefore, a new strategy involves the identification of multi‐kinase inhibitors to slow the development of potential resistance. Moreover, the expected side effects of the first nonselective inhibitors were less dramatic than had been expected. We have discovered novel 4‐benzylamino‐α‐carbolines as a new class of RTK inhibitors. Docking studies suggest a binding mode to the addressed target structures of the epidermal growth factor receptor (EGFR) and to the vascular endothelial growth factor receptor 2 (VEGFR2). Selectivity profiling against a panel of kinases and antiproliferative studies have highlighted one inhibitor, active in the nanomolar range, as a highly interesting candidate for further clinical studies.     

Multipoint thermal-probe monitoring the radial gas distribution in blast furnaces with nonconical charging systems at OAO MMK

Uncooled multipoint thermal probes are used to monitor the radial gas distribution in blast furnaces with nonconical charging systems at OAO MMK. In each furnace two probes are placed at fixed locations above the charge. Such probes have been installed in all four furnaces with nonconical charging systems at OAO MMK and are now in an operational state.     

Effect of adding schungite to the blast-furnace charge on the smelting operation and the smelting products

Positive results obtained at several plants from the use of schungite in pig-iron smelting motivated the MMK to conduct trial heats on its blast furnaces. The use of schungite in short trial heats showed a decrease in coke rate and an increase in furnace productivity. __________ Translated from Metallurg, No. 1, pp. 38–40, January, 2007.     

Structure-Based Cyclic Glycoprotein Ibα-Derived Peptides Interfering with von Willebrand Factor-Binding,Affecting Platelet Aggregation under Shear

The plasmatic von Willebrand factor (VWF) circulates in a compact form unable to bind platelets. Upon shear stress, the VWF A1 domain is exposed, allowing VWF-binding to platelet glycoprotein Ib-V-IX (GPIbα chain). For a better understanding of the role of this interaction in cardiovascular disease, molecules are needed to specifically interfere with the opened VWF A1 domain interaction with GPIbα. Therefore, we in silico designed and chemically synthetized stable cyclic peptides interfering with the platelet-binding of the VWF A1 domain per se or complexed with botrocetin. Selected peptides (26–34 amino acids) with the lowest-binding free energy were: the monocyclic mono- vOn Willebrand factoR-GPIbα InTerference (ORbIT) peptide and bicyclic bi-ORbIT peptide. Interference of the peptides in the binding of VWF to GPIb-V-IX interaction was retained by flow cytometry in comparison with the blocking of anti-VWF A1 domain antibody CLB-RAg35. In collagen and VWF-dependent whole-blood thrombus formation at a high shear rate, CLB-RAg35 suppressed stable platelet adhesion as well as the formation of multilayered thrombi. Both peptides phenotypically mimicked these changes, although they were less potent than CLB-RAg35. The second-round generation of an improved peptide, namely opt-mono-ORbIT (28 amino acids), showed an increased inhibitory activity under flow. Accordingly, our structure-based design of peptides resulted in physiologically effective peptide-based inhibitors, even for convoluted complexes such as GPIbα-VWF A1.     

Axisymmetric loading on nanoscale multilayered media

Multilayered nanoscale structures are used in several applications. Because the effect of surface energy becomes nontrivial at such a small scale, a modified continuum theory is required to accurately predict their mechanical behaviors. A Gurtin–Murdoch continuum model of surface elasticity is implemented to establish a computational scheme for investigating an elastic multilayered system under axisymmetric loads with the incorporation of surface/interface energy. Each layer stiffness matrix is derived based on the general solutions of stresses and displacements obtained in the form of the Hankel integral transform. Numerical solutions to the global equation, which are formulated based on the continuity conditions of tractions and displacements across interfaces between layers, yield the displacements at each layer interface and on the top surface of the multilayered medium. The numerical solutions indicate that the elastic responses of multilayered structures are affected significantly by the surface material properties of both the top surface and interfaces, and that they become size dependent. In addition, the indentation problem of a multilayered nanoscale elastic medium under a rigid frictionless cylindrical punch is investigated to demonstrate the application of the proposed solution scheme.