Unusual Two-Step Assembly of a Minimalistic Dipeptide-Based Functional Hypergelator

Self-assembled peptide hydrogels represent the realization of peptide nanotechnology into biomedical products. There is a continuous quest to identify the simplest building blocks and optimize their critical gelation concentration (CGC). Herein, a minimalistic, de novo dipeptide, Fmoc-Lys(Fmoc)-Asp, as an hydrogelator with the lowest CGC ever reported, almost fourfold lower as compared to that of a large hexadecapeptide previously described, is reported. The dipeptide self-assembles through an unusual and unprecedented two-step process as elucidated by solid-state NMR and molecular dynamics simulation. The hydrogel is cytocompatible and supports 2D/3D cell growth. Conductive composite gels composed of Fmoc-Lys(Fmoc)-Asp and a conductive polymer exhibit excellent DNA binding. Fmoc-Lys(Fmoc)-Asp exhibits the lowest CGC and highest mechanical properties when compared to a library of dipeptide analogues, thus validating the uniqueness of the molecular design which confers useful properties for various potential applications.     

A heuristic for dynamic yard crane deployment in a container terminal

Rubber Tired Gantry Cranes (RTGCs) are the most widely used pieces of equipment in the Hong Kong sea-freight container yards. Workload distribution in the yard changes continuously over time. The dynamic deployment of RTGCs is an important issue in yard operation management. This paper investigates the dynamic crane deployment problem with the objective of determining the crane deployment frequency and routes over a planning horizon to minimize the total workload overflow. The problem is formulated as a mixed integer programming model. A heuristic algorithm is then developed to solve problems of practical sizes. The heuristic quickly finds a near optimal solution for crane deployment operation.     

Family burden following traumatic brain injury.

Investigated burden experienced by 60 spouses and 71 parents who served as primary caregivers to individuals with traumatic brain injury (BI). Burden levels, as assessed by the Questionnaire on Resources and Stress (QRS-SF), were compared for spouses and parents. Both parents and spouses exhibited high levels of burden. Relative to spouses, parents reported significantly greater burden related to lifespan care. Spouses reported significantly less personal reward than did parents. The presence of social aggression and cognitive disability in the individual with BI was found to have a greater association with subjective burden of caregivers than was the presence of physical disability or injury severity. Results of previous studies with QRS-SF scores show that the responsibility assumed by spouses and parents of persons with BI was as great as that experienced by families of people with severe chronic physical disabilities. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Photo Sequencing

A group of people taking pictures of a dynamic event with their mobile phones is a popular sight. The set of still images obtained this way is rich in dynamic content but lacks accurate temporal information. We propose a method for photo-sequencing—temporally ordering a set of still images taken asynchronously by a set of uncalibrated cameras. Photo-sequencing is an essential tool in analyzing (or visualizing) a dynamic scene captured by still images. The first step of the method detects sets of corresponding static and dynamic feature points across images. The static features are used to determine the epipolar geometry between pairs of images, and each dynamic feature votes for the temporal order of the images in which it appears. The partial orders provided by the dynamic features are not necessarily consistent, and we use rank aggregation to combine them into a globally consistent temporal order of images. We demonstrate successful photo-sequencing on several challenging collections of images taken using a number of mobile phones.     

铸铁坩锅抗铝融蚀等离子喷涂技术

针对提高化铝用铸铁坩埚抗融蚀寿命的实际问题,选用价格较低、耐高温、抗融蚀性好的Ａｌ２Ｏ３陶瓷材料作为坩埚内壁的工作层,采用等离子喷涂技术来提高其抗融蚀性。但由于Ａｌ２Ｏ３陶瓷涂层的致密性差、结合强度及抗热震寿命低等缺点,不适宜化铝坩埚在７２０℃长时间加温,且液铝呈搅拌行为的工作条件下使用。本文在Ａｌ２Ｏ３喷涂粉末中加入１３％ＴｉＯ２,促使涂层的组织结构发生变化,提高了涂层的结合强度,改善了涂层的致     

A probabilistic alternative to regression suites

Automated regression suites are essential in developing large applications, while maintaining reasonable quality and timetables. The main argument against the automation of regression suites, in addition to the cost of creation and maintenance, is the observation that if you run the same test many times, it becomes increasingly less likely to find bugs. To alleviate such problems, a new regression suite practice, using random test generators to create regression suites on-the-fly, is becoming more common. In this practice, instead of maintaining tests, we generate test suites on-the-fly by choosing several specifications and generating a number of tests from each specification.     

Numerical aspects of a Godunov-type stabilization scheme for the Boltzmann transport equation

Journal of Computational Electronics - We discuss the numerical aspects of the Boltzmann transport equation (BE) for electrons in semiconductor devices, which is stabilized by Godunov’s...     

Automatic boosting of cross-product coverage using Bayesian networks

Closing the feedback loop from coverage data to the stimuli generator is one of the main challenges in the verification process. Typically, verification engineers with deep domain knowledge manually prepare a set of stimuli generation directives for that purpose. Bayesian networks based CDG (coverage directed generation) systems have been successfully used to assist the process by automatically closing this feedback loop. However, constructing these CDG systems requires manual effort and a certain amount of domain knowledge from a machine learning specialist. We propose a new method that boosts coverage in the early stages of the verification process with minimal effort, namely a fully automatic construction of a CDG system that requires no domain knowledge. Experimental results on a real-life cross-product coverage model demonstrate the efficiency of the proposed method.     

Identification of the female-produced sex pheromone of the scarab beetle,Hoplia equina

Hoplia equina LeConte (Coleoptera: Scarabaeidae: Melolonthinae) is a beetle pest of cranberry beds in Massachusetts. Larvae feed on the roots of the cranberry plant, reducing yield as well as vine density. The female sex pheromone was identified as 2-tetradecanone. There were eight compounds found in the airborne volatiles collected from females that elicited antennal responses from males. Of the eight compounds tested (nonanal, decanal, dodecanal, 2-dodecanone, 2-tridecanone, 2-tetradecanone, 2-pentadecanone, and 2-hexadecanone), 2-tetradecanone was the only one that attracted male beetles in the field. Combining any of the other seven antennally active compounds with 2-tetradecanone did not increase male capture.     

Continuous input nonlocal games

We present a family of nonlocal games in which the inputs the players receive are continuous. We study three representative members of the family. For the first two a team sharing quantum correlations (entanglement) has an advantage over any team restricted to classical correlations. We conjecture that this is true for the third member of the family as well.