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IH Bjerkli R Myklebust S R?is?nen S Telimaa LE Stenfors 《Canadian Metallurgical Quarterly》1996,36(3):205-213
Dopaminergic agents and carbidopa/levodopa have become the preferred treatment for both the restless legs (RL) syndrome and for periodic limb movements in sleep (PLMS). For once-nightly treatments with carbidopa/ levodopa, a problem with morning end-of-dose rebound increases in leg movements has been reported to occur in the about one-fourth of the patients. In our clinical studies a previously unreported but far more significant problem of markedly augmented RL symptoms occurred in the afternoon and the evening prior to taking the next nightly dose. A systematic prospective evaluation of this augmentation in 46 consecutive patients treated with carbidopa/ levodopa for RL syndrome or PLMS disorder found this augmentation to be the major adverse effect of treatment. Augmentation occurred for 31% of PLMS patients and 82% of all RL patients. It was greater for subjects with more severe RL symptoms and for patients on higher doses (> or = 50/200 mg carbidopa/levodopa) but was unrelated to gender, age or baseline severity of PLMS. This augmentation was severe enough to require medication change for 50% of the RL patients and 13% of PLMS patients. Augmentation resolved with cessation of the medication and could be minimized by keeping the dose low. 相似文献
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Recurrent erosion of the corneal epithelium has been treated successfully by phototherapeutic keratectomy when convention therapy has failed. We present a case of recurrent corneal erosion occurring 1 year after photorefractive keratectomy in a 55-year-old myopic woman. No corneal abnormalities were previously identified in either the affected or the fellow eye. This case demonstrates the potential for ineffective healing of the corneal epithelial basement membrane complex after excimer laser photorefractive keratectomy. 相似文献
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LE Lindner 《Canadian Metallurgical Quarterly》1993,41(3):439-445
The silver-staining technique for nucleolar organizer regions (AgNOR) of Ploton et al., as popularized by Crocker, is being widely used for evaluation of nucleolar function, especially in neoplasia. It suffers from limited reliability, background staining, precipitates, and fading of the sections. Factors were identified that affect these problems. The oxidation-reduction level and gelatin used are particularly important. An improved procedure is presented which incorporates pre-reduction of the sections, selection of an optimal gelatin, and post-treatment of the sections to produce a permanent preparation. It is compatible with many fixatives and with other stains used before or after the silver stain. 相似文献
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D Averill D Blockus B Brabson J Brom C Jung H Ogren DR Rust M Derrick P Kooijman JS Loos B Musgrave LE Price J Repond K Sugano B Cork C Akerlof J Chapman D Errede MT Ken DI Meyer H Neal D Nitz R Thun R Tschirhart S Abachi P Baringer BG Bylsma R DeBonte D Koltick EH Low RL McIlwain DH Miller CR Ng EI Shibata 《Canadian Metallurgical Quarterly》1989,39(1):123-137
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王小刚 《常州信息职业技术学院学报》2005,4(Z1):32-34
针对当前学生因迷恋网络而影响学业的突出问题,透过现象,分析存在这些问题的根源.通过剖析信息网络对学风建设的利弊影响,针对性地提出了趋利避害的方法与措施,这为当前高职院校的学风建设提出了富有建设性的思考与探索. 相似文献
8.
碾压混凝土穿透型诱导缝不同扩展阶段的强度指标试验研究 总被引:2,自引:0,他引:2
在不同削弱度碾压混凝土轴拉试件的穿透型诱导缝周围粘贴了应变片,得到在不同应力状态下诱导缝应变发展规律为:在加载初期,离缝端不同距离的应变发展较为均匀,数值上相差不突出;随着荷载的增加,应变开始出现不均匀发展,离缝端越远,应变变化越缓慢;当接近最大荷载的阶段,缝端应变急速发展,试件瞬间断裂。应变从均匀发展变为不均匀发展,实质上隐含了诱导缝起裂、稳定发展、失稳断裂的整个过程,针对这一试验现象,结合断裂力学理论,建立了诱导缝不同开裂阶段的远场温度应力强度指标模型。 相似文献
9.
The technique of immunocytochemistry was used to identify myoglobin in kidney, confirming a diagnosis of neuroleptic malignant syndrome following an otherwise obscure autopsy in a decomposed body. The features of neuroleptic malignant syndrome are reviewed with a differential diagnosis of myoglobin renal casts. The report emphasizes a thorough and detailed assessment of deaths which occur during treatment with neuroleptic drugs. 相似文献
10.
We developed a new in vitro model of neuronal injury using NT2-N cells to examine the effects of hydrodynamic loading rate on intraneuronal calcium dynamics and lactate dehydrogenase (LDH) release. Our apparatus consisted of a parallel disk viscometer which induced fluid shear stress with well-defined magnitudes and loading rates to cultured cells. We found that the deformation response of the cells was dependent on the severity of the insult, with increased cellular strains generated for higher shear stresses at a constant loading rate. Peak intracellular free calcium concentration correlated with strain, suggesting that mechanical deformation may regulate calcium response. Slowly applied fluid shear stress elicited no response, whereas high loading rates resulted in peak calcium increases 2.9 to 3.6 times baseline values as injury severity was increased. LDH release measured within 5 min after the insult correlated with loading rate. In addition, LDH release continued to increase out to 24 h following high loading rate conditions, demonstrating that the application of fluid shear stress led to prolonged cell damage. The acute response in NT2-N cells subjected to an insult with the CSID is dependent on the loading rate, and these results suggest that initial membrane deformation may trigger subsequent events. 相似文献