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Philippe Coni Jean‐Luc Bardon Aude Gueguen Matthieu Grossetête 《Journal of the Society for Information Display》2017,25(3):158-166
A 3D stereoscopic head‐up display using a tunable bandpass filter to perform left and right image spectral separation is presented. Using a single filter reduces the size and the cost of the head‐up display optical engine and enables each spectral band to be accurately tuned. Experiments performed on the first prototype demonstrate the ability to continuously tune the bandpass frequency on 30‐nm range while keeping a 20‐nm bandwidth. Such a system avoids the use of a bulky and costly rotating wheel and enables the use of holographic optical elements known to be wavelength selective. 相似文献
3.
Jean Mayrand Jean-François Patenaude Ettore Merlo Michel Dagenais Bruno Laguë 《Annals of Software Engineering》2000,9(1-2):117-141
This paper presents an assessment method to evaluate the quality of object oriented software systems. The assessment method is based on source code abstraction, object–oriented metrics and graphical representation. The metrics used and the underlying model representing the software are presented. The assessment method experiment is part of an industrial research effort with the Bell Canada Quality Engineering and Research Group. It helps evaluators assess the quality and risks associated with software by identifying code fragments presenting unusual characteristics. The assessment method evaluates object–oriented software systems at three levels of granularity: system level, class level and method level. One large C++ and eight Java software systems, for a total of over one million lines of code, are presented as case studies. A critical analysis of the results is presented comparing the systems and the two languages. 相似文献
4.
Teodolinda Di Risi Mariella Cuomo Roberta Vinciguerra Sara Ferraro Rosa Della Monica Davide Costabile Michela Buonaiuto Federica Trio Ettore Capoluongo Roberta Visconti Eleonora Riccio Antonio Pisani Lorenzo Chiariotti 《International journal of molecular sciences》2022,23(20)
Anderson–Fabry disease (FD) is an X-linked disease caused by a functional deficit of the α-galactosidase A enzyme. FD diagnosis relies on the clinical manifestations and research of GLA gene mutations. However, because of the lack of a clear genotype/phenotype correlation, FD diagnosis can be challenging. Recently, several studies have highlighted the importance of investigating DNA methylation patterns for confirming the correct diagnosis of different rare Mendelian diseases, but to date, no such studies have been reported for FD. Thus, in the present investigation, we analyzed for the first time the genome-wide methylation profile of a well-characterized cohort of patients with Fabry disease. We profiled the methylation status of about 850,000 CpG sites in 5 FD patients, all carrying the same mutation in the GLA gene (exon 6 c.901C>G) and presenting comparable low levels of α-Gal A activity. We found that, although the whole methylome profile did not discriminate the FD group from the unaffected one, several genes were significantly differentially methylated in Fabry patients. Thus, we provide here a proof of concept, to be tested in patients with different mutations and in a larger cohort, that the methylation state of specific genes can potentially identify Fabry patients and possibly predict organ involvement and disease evolution. 相似文献
5.
Fortuna Iannuzzo Vincenzo Piccolo Ettore Novellino Elisabetta Schiano Emanuela Salviati Vincenzo Summa Pietro Campiglia Gian Carlo Tenore Maria Maisto 《International journal of molecular sciences》2022,23(21)
Proanthocyanidins (PACs) are a group of bioactive molecules found in a variety of plants and foods. Their bioavailability depends on their molecular size, with monomers and dimers being more bioavailable than those that have a higher polymerization degree. This study aimed to develop a method to convert high-molecular-weight PACs to low-molecular-weight ones in a grape seed extract (GSE) from Vitis vinifera L. Therefore, GSE was subjected to alkaline treatment (ATGSE), and its difference in chemical composition, compared to GSE, was evaluated using a molecular networking (MN) approach based on results obtained from HPLC-ESI HRMS/MS characterization analysis. The network analysis mainly noted the PAC cluster with about 142 PAC compounds identified. In particular, the obtained results showed a higher content of monomeric and dimeric PACs in ATGSE compared to GSE, with 58% and 49% monomers and 31% and 24% dimers, respectively. Conversely, trimeric (9%), polymeric (4%), and galloylated PACs (14%) were more abundant in GSE than in ATGSE (6%, 1%, and 4%, respectively). Moreover, in vitro antioxidant and anti-inflammatory activities were investigated, showing the high beneficial potential of both extracts. In conclusion, ATGSE could represent an innovative natural matrix rich in bioavailable and bioaccessible PACs for nutraceutical applications with potential beneficial properties. 相似文献
6.
Ettore BompardAuthor Vitae Di WuAuthor VitaeFei XueAuthor Vitae 《Electric Power Systems Research》2011,81(7):1334-1340
Vulnerability analysis of power systems is a key issue in modern society and many efforts have contributed to the analysis. Complex network metrics for the assessment of the vulnerability of networked systems have been recently applied to power systems. Complex network theory may come in handy for vulnerability analysis of power systems due to a close link between the topological structure and physical properties of power systems. However, a pure topological approach fails to capture the engineering features of power systems. So an extended topological method has been proposed by incorporating several of specific features of power systems such as electrical distance, power transfer distribution factors and line flow limits. This paper defines, starting from the extended metric for efficiency named as net-ability, an extended betweenness and proposes a joint method of extended betweenness and net-ability to rank the most critical lines and buses in an electrical power grid. The method is illustrated in the IEEE-118-bus, IEEE-300-bus test systems as well as the Italian power grid. 相似文献
7.
Nicola Barbieri Giuseppe Manco Ettore Ritacco Marco Carnuccio Antonio Bevacqua 《Machine Learning》2013,93(1):5-29
Probabilistic topic models are widely used in different contexts to uncover the hidden structure in large text corpora. One of the main (and perhaps strong) assumption of these models is that generative process follows a bag-of-words assumption, i.e. each token is independent from the previous one. We extend the popular Latent Dirichlet Allocation model by exploiting three different conditional Markovian assumptions: (i) the token generation depends on the current topic and on the previous token; (ii) the topic associated with each observation depends on topic associated with the previous one; (iii) the token generation depends on the current and previous topic. For each of these modeling assumptions we present a Gibbs Sampling procedure for parameter estimation. Experimental evaluation over real-word data shows the performance advantages, in terms of recall and precision, of the sequence-modeling approaches. 相似文献
8.
The paper deals with the comparison between a high-end marker-based acquisition system and a low-cost marker-less methodology for the assessment of the human posture during working tasks. The low-cost methodology is based on the use of a single Microsoft Kinect V1 device. The high-end acquisition system is the BTS SMART that requires the use of reflective markers to be placed on the subject's body. Three practical working activities involving object lifting and displacement have been investigated. The operational risk has been evaluated according to the lifting equation proposed by the American National Institute for Occupational Safety and Health. The results of the study show that the risk multipliers computed from the two acquisition methodologies are very close for all the analysed activities. In agreement to this outcome, the marker-less methodology based on the Microsoft Kinect V1 device seems very promising to promote the dissemination of computer-aided assessment of ergonomics while maintaining good accuracy and affordable costs. 相似文献
9.
Distance fields are scalar functions defining the minimum distance of a given point in the space from the boundary of an object. Crack surfaces are geometric entities whose shapes can be arbitrary, often described with ruled surfaces or polygonal subdivisions. The derivatives of distance functions for such surfaces are discontinuous across the surface, and continuous all around the edges. These properties of the distance function were employed to build intrinsic enrichments of the underlying mesh-free discretisation for efficient simulation of three-dimensional crack propagation, removing the limitations of existing criteria (reviewed in this paper). Examples show that the proposed approach is able to introduce quite convoluted crack paths. The incremental nature of the developed approach does not require re-computation of the enrichment for the entire crack surface as advancing crack front extends incrementally as a set of connected surface facets. The concept is based on purely geometric representation of discontinuities thus addressing only the kinematic aspects of the problem, such to allow for any constitutive and cohesive interface models to be used. 相似文献
10.
Illicit drug consumption estimations derived from wastewater analysis: A critical review 总被引:1,自引:0,他引:1
Alexander L.N. van NuijsSara Castiglioni Isabela TarcomnicuCristina Postigo Miren Lopez de AldaHugo Neels Ettore ZuccatoDamia Barcelo Adrian Covaci 《The Science of the total environment》2011,409(19):3564-3577
The consumption of illicit drugs causes indisputable societal and economic damage. Therefore it is necessary to know their usage levels and trends for undertaking targeted actions to reduce their use. Recently, a new approach (namely sewage epidemiology) was developed for the estimation of illicit drug use based on measurements of urinary excreted illicit drugs and their metabolites in untreated wastewater. This review aims at critically evaluating the published literature and identifying research gaps of sewage epidemiology. Firstly, the existing analytical procedures for the determination of the four most used classes of illicit drugs worldwide (cannabis, cocaine, opiates and amphetamine-like stimulants) and their metabolites in wastewater are summarized and discussed. The focus lies on the sample preparation and on the analysis with chromatographic techniques coupled to mass spectrometry. Secondly, back-calculations used to transform measured concentrations in wastewater (in ng/L) into an amount of used illicit drug (in g/day per 1000 inhabitants or doses/day per 1000 inhabitants) are discussed in detail for the four groups of illicit drugs. Sewage epidemiology data from Spain, Belgium, UK, Italy, Switzerland and USA are summarized and compared with data from international organisations, such as the European Monitoring Centre for Drug and Drug Addiction (EMCDDA) and the United Nations Office on Drugs and Crime (UNODC). The results derived from wastewater analysis show in general good agreement with existing prevalence data (percentage of a population that uses illicit drugs at a given time) and demonstrate the potential of sewage epidemiology. However, this review confirms that future work should focus on further optimisation and standardisation of various important parameters (e.g. sample collection and back-calculations). In the future, sewage epidemiology could be used in routine drug monitoring campaigns as a valuable tool in addition to the classical socio-epidemiological studies for the determination of local, national and international illicit drug use. 相似文献