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排序方式: 共有225条查询结果,搜索用时 0 毫秒
1.
Mateusz Schabikowski Magdalena Laskowska Pawe Kowalczyk Andrii Fedorchuk Emma Szri-Doroghzi Zoltn Nmeth Dominika Ku
ma Barbara Gawdzik Aleksandra Wypych Karol Kramkowski ukasz Laskowski 《International journal of molecular sciences》2022,23(15)
In this article, we describe the antimicrobial properties of a new composite based on anodic aluminium oxide (AAO) membranes containing propyl-copper-phosphonate units arranged at a predetermined density inside the AAO channels. The samples were prepared with four concentrations of copper ions and tested as antimicrobial drug on four different strains of Escherichia coli (K12, R2, R3 and R4). For comparison, the same strains were tested with three types of antibiotics using the minimal inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) tests. Moreover, DNA was isolated from the analysed bacteria which was additionally digested with formamidopyrimidine-DNA glycosylase (Fpg) protein from the group of repair glycosases. These enzymes are markers of modified oxidised bases in nucleic acids produced during oxidative stress in cells. Preliminary cellular studies, MIC and MBC tests and digestion with Fpg protein after modification of bacterial DNA suggest that these compounds may have greater potential as antibacterial agents than antibiotics such as ciprofloxacin, bleomycin and cloxacillin. The described composites are highly specific for the analysed model Escherichia coli strains and may be used in the future as new substitutes for commonly used antibiotics in clinical and nosocomial infections in the progressing pandemic era. The results show much stronger antibacterial properties of the functionalised membranes on the action of bacterial membranes in comparison to the antibiotics in the Fpg digestion experiment. This is most likely due to the strong induction of oxidative stress in the cell through the breakdown of the analysed bacterial DNA. We have also observed that the intermolecular distances between the functional units play an important role for the antimicrobial properties of the used material. Hence, we utilised the idea of the 2D solvent to tailor them. 相似文献
2.
Karel Klíma Dan Ulmann Martin Barto Michal panko Jaroslava Dukov Radka Vrbov Jan Pinc Jií Kubsek Marek Vlk Tereza Ulmannov Ren Foltn Eitan Brizman Milan Draho Michal Beo Vladimír Macho Jaroslav apek 《International journal of molecular sciences》2021,22(24)
The increasing incidence of trauma in medicine brings with it new demands on the materials used for the surgical treatment of bone fractures. Titanium, its alloys, and steel are used worldwide in the treatment of skeletal injuries. These metallic materials, although inert, are often removed after the injured bone has healed. The second-stage procedure—the removal of the plates and screws—can overwhelm patients and overload healthcare systems. The development of suitable absorbable metallic materials would help us to overcome these issues. In this experimental study, we analyzed an extruded Zn-0.8Mg-0.2Sr (wt.%) alloy on a rabbit model. From this alloy we developed screws which were implanted into the rabbit tibia. After 120, 240, and 360 days, we tested the toxicity at the site of implantation and also within the vital organs: the liver, kidneys, and brain. The results were compared with a control group, implanted with a Ti-based screw and sacrificed after 360 days. The samples were analyzed using X-ray, micro-CT, and a scanning electron microscope. Chemical analysis revealed only small concentrations of zinc, strontium, and magnesium in the liver, kidneys, and brain. Histologically, the alloy was verified to possess very good biocompatibility after 360 days, without any signs of toxicity at the site of implantation. We did not observe raised levels of Sr, Zn, or Mg in any of the vital organs when compared with the Ti group at 360 days. The material was found to slowly degrade in vivo, forming solid corrosion products on its surface. 相似文献
3.
弧焊电源的性能是影响焊接质量及其使用安全的重要因素,因此需要专用设备对出厂的弧焊电源进行检测。该弧焊电源测试设备是主从式结构,由硬件系统和软件系统两大部分组成。硬件系统由嵌入式微控制器控制,主要完成设备数据采集和信息显示,软件系统在嵌入式Linux环境下进行开发,完成图形用户界面程序及采集程序的编写。该设备可以实现对弧焊电源的自动测试,如负载加载、数据传输等,体现了良好的人机交互性。本系统将应用于电焊机的出厂检验,通过对弧焊电源的电参数的测试来评估被测产品的质量和性能。 相似文献
4.
X-ray diffraction data have been used in compiling equilibrium phase diagrams for the Lu?Cr?B and Lu?Mo?B systems at 1270 K. The boride LuB2 dissolves not more than 0.03 molar part of CrB2 and 0.30 molar part of MoB2. The existence of compound LuCrB4 is confirmed (structure of YCrB4 type) and the same for Lu2MoB6 (structure of Y2ReB6 type). A homogeneity regions is identified for the boride Lu2MoB6, which ranges up to the composition LuMoB4. 相似文献
5.
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7.
三维CAD技术在水利水电工程设计中的应用 总被引:1,自引:0,他引:1
本文结合水利水电工程设计任务,介绍了建立在三维数字模型下的三维CAD技术的应用领域及其设计特点。 相似文献
8.
Naïma Amrani Ahmed Boucenna 《Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms》2008,266(6):926-928
The effectiveness of transmutation for the long-lived fission product Technetium-99 in a high flux research reactor is evaluated, taking into account its large capture cross section in the thermal and epithermal regions. Calculation of the evolution of the Ruthenium concentration under irradiation was performed using the ChainSolver 2.20 code. The results on Technetium transmutation suggest an effective use of this kind of research reactors and describes a new concept of multi-recycle Technetium transmutation using HFRTRAN (high flux research reactor for transmutation). 相似文献
9.
Typical thicknesses of high-strength steels (HSS) sheets used in the car industry are inapplicable for standardized testing
procedures. The aim of this study is to propose an appropriate methodology for testing and comparing of thin HSS sheets. Microstructures
were observed by means of light and scanning electron microscopy. The modified Charpy impact tests and fracture toughness
tests were used in order to compare the fracture properties of three different HSS sheets (Docol 1200 M, Multiphase 1200 and
BTR 165). Ductile-to-brittle transition curves and tearing resistance (J − Δa) curves were measured. From the fracture toughness
linked to the specimen thicknesses the value of fracture toughness KIc was estimated. Fractographic analysis of broken specimens has revealed that due to the fine microstructure of mixed ferrite-martensite
fracture mechanism remains ductile even at low temperatures (down to −100°C).
__________
Translated from Problemy Prochnosti, No. 1, pp. 155–158, January–February, 2008. 相似文献
10.
Mariana Ušáková Jozef Lukáč Rastislav Dosoudil Vladimír Jančárik Anna Grusková Elemír Ušák Jozef Sláma Jan Šubrt 《Journal of Materials Science: Materials in Electronics》2007,18(12):1183-1189
The paper is devoted to the preparation of NiZn ferrite with small substitutions of copper by means of ceramic technology.
The influence of small Cu substitution on the microstructural and magnetic properties of NiZn ferrites have been analysed
by means of various experimental methods and interpreted from the point of view of preparation technology optimisation and
possible applications of such materials. A strong correlation between the substituent content and resulting properties has
been observed, thus allowing preparation of material with the properties tailored for any particular application. 相似文献