热镀锌板(卷)工程设计中的环境保护问题

对热镀锌板(卷)的生产工艺、主要生产设备进行了简要介绍，并就其污染源(工序)、生产过程中产生的污染物及其控制措施进行了评述，同时就设计和生产中宜注意的几个环保问题进行了分析。     

Prolonged tamoxifen exposure selects a breast cancer cell clone that is stable in vitro and in vivo

The effects of long-term tamoxifen exposure on cell growth and cell cycle kinetics were compared between oestrogen receptor (ER)-positive (MCF-7) and ER-negative (MDA-MB-231) cell lines. In the MCF-7 cell line, prolonged tamoxifen exposure (0.5 mumol/l for > 100 days) blocked cells in G0-G1 of the cell cycle, and slowed the doubling time of cells from 30 to 59 h. These effects corresponded to an increase in the cellular accumulation of tamoxifen over time [mean area under concentration curve (AUC) = 77.92 mumoles/10(6)/cells/day]. In contrast, in the MDA-MB-231 cell line, long-term tamoxifen exposure had no obvious effect on the doubling time, and reduced cellular tamoxifen accumulation (mean AUC = 50.50 mumoles/10(6)/cells/day) compared to the MCF-7 cells. Flow cytometric analysis of MDA-MB-231 cells demonstrated that a new tetraploid clone emerged following 56 days of tamoxifen exposure. Inoculation of the MDA-MB-231 tetraploid clone and MDA-MB-231 wildtype cells into the opposite flanks of athymic nude mice resulted in the rapid growth of tetraploid tumours. The tetraploid tumours maintained their ploidy following tamoxifen treatment for nine consecutive serial transplantations. Histological examination of the fifth transplant generation xenografts revealed that the tetraploid tumour had a 25-30 times greater mass, area of haemorrhage and necrosis, a slightly higher mitotic index and was more anaplastic than the control neoplasm. The control wildtype MDA-MB-231 tumours maintained a stable ploidy following tamoxifen treatment until the eighth and ninth transplantation, when a tetraploid population appeared, suggesting that tamoxifen treatment may select for this clone in vivo. These studies suggest that prolonged tamoxifen exposure may select for new, stable, fast growing cell clones in vitro as well as in vivo.     

Photoluminescence and X-ray Diffraction of Distributed Bragg Reflector

Spectral and structural characteristics of distributed Bragg reflector (DBR) in vertical-cavity surface-emitting lasers were studied with photoluminescence and double- crystal X- ray diffraction measurement. The expected high quality epitaxial DBR structure was verified. In the X- ray double- crystal rocking curves of DBR the zeroth- order peak, the first and second order satellite peaks were measured. Splitting of diffraction peak appeared in the rocking curves was analyzed. The effects of introduced deep energy levels on the structural perfection and optical properties were discussed.     

引水发电系统无压隧洞中弃水堰位置的数值模拟研究

水电站引水发电系统无压隧洞中的水力过渡过程是近年来电站设计中出现的一个新课题,特别是流域梯级电站开发中经常遇到。结合工程实例应用扩散法,给出了无压隧洞水力过渡过程数值模拟的基本方程以及上下游及弃水堰等边界附加方程,模拟了弃水堰布置在不同位置下,无压隧洞内的水位变化过程。研究成果和讨论对实际工程应用具有参考意义。     

Accuracy of using computed tomography to identify pedicle screw placement in cadaveric human lumbar spine

STUDY DESIGN: Utility of using computed tomography to predict pedicle screw misplacement. OBJECTIVE: This study defines the sensitivity and specificity of predicting pedicle screw placement by experienced clinicians using a CT scan image. SUMMARY OF BACKGROUND DATA: In clinical and research settings, the method most commonly used to evaluate pedicle screws placement has been computed tomography. However, no current literature describes the accuracy of this method of evaluating screw placement. METHOD: Cobalt-chrome and titanium alloy pedicle screws of identical size were placed in six cadaveric human lumbar spine. Wide laminectomy was performed to allow complete visualization of the pedicles. Three consecutive lumbar levels were instrumented in each spine, giving 36 pedicle screw placements to identify. The instrumented spines were imaged, and four orthopaedic spine surgeons and a musculoskeletal radiologist were asked to read the images to identify the accuracy of screw placement within the pedicles. RESULTS: The sensitivity rate of identifying a misplaced screw was 67 +/- 6% for cobalt-chrome screws compared with 86 +/- 5% for titanium screws (P < 0.005). The specificity rates of radiographic diagnosis of misplaced pedicle screws were 66 +/- 10% for cobalt-chrome screws and 88 +/- 8% for titanium screws (P < 0.005). Similarly, a statistically significant difference was found in the sensitivity rates of identifying screws placed correctly in the pedicle: 70 +/- 10% for cobalt-chrome screws versus 89 +/- 8% for titanium screws (P < 0.005). Overall accuracy rates were 68 +/- 7% for cobalt chrome screws versus 87 +/- 3% for titanium screws (P < 0.002). CONCLUSION: Reliance on the computed tomography scan data alone in determining accuracy of pedicle screws can lead to inaccuracies in both clinical and research conditions.     

时空效应规律在软土深基坑工程中的运用

阐述了时空效应规律在软土深基坑工程中的运用情况，实践证明，运用时空效应规律，能可靠而合理地利用土体自身在基坑开挖过程中控制土体位移的潜力而达到保护环境的目的。     

高频微型脉冲管制冷机的实用化研究

脉冲管制冷机经过多年的发展，性能不断改善，目前已开始进入实用化阶段。高频微型脉冲管制冷机结构紧凑，应用方便，并且主要工作在需求量较大的液氮温区，因此将首先得到一定规模的应用。介绍了作者针对脉冲管制冷机在红外和超导方面的应用所作的实用化工作，讨论了尚待解决的问题。     

柴油机针阀体的乙炔低压渗碳

乙炔低压渗碳可以有效地避免在真空渗碳过程中产生炭黑和焦油，同时由于乙炔具有较高的供碳能力，使这一技术尤其适用于针阀体这样的小直径深盲孔零件。     

材质对蜂窝纸板缓冲性能的影响

对两种不同材质的蜂窝纸板静态应力应变性能和动态缓冲结果进行了比较分析。讨论了蜂窝纸板力学性能对应变速度的敏感性及两种纸板的缓冲性能差异。缓冲试验结果表明。在不同的冲击应变率下蜂窝纸板的材质影响蜂窝纸板缓冲性能。     

冀东油田水平井井身结构优化设计

冀东油田油藏、地层、井网复杂,确定适合冀东油田地层特点的水平井最佳井身结构至关重要,压力系数和相关参数的确定是井身结构优化设计的重要基础.针对冀东油田不同区块复杂地层和油藏特性及井身结构设计中的关键事项,利用三压力剖面预测技术,分析出不同区块的三压力剖面分布情况,根据相关参数的确定原则、方法和冀东油田多年研究和钻井实践,得出了不同区块的3个压力系数分布范围及井身结构设计工程系数范围,为合理确定井身结构提供依据.基于以上设计基础,按照井身结构设计基本原则,利用井身结构设计的具体方法和步骤,设计出了适合冀东油田的最优水平井井身结构.