Distinctiveness and Correlation in Conceptual Structure: Behavioral and Computational Studies.

Patients with category-specific deficits have motivated a range of hypotheses about the structure of the conceptual system. One class of models claims that apparent category dissociations emerge from the internal structure of concepts rather than fractionation of the system into separate substores. This account claims that distinctive properties of concepts in the living domain are vulnerable because of their weak correlation with other features. Given the assumption that mutual activation among correlated properties produces faster activation in the normal system, the authors predicted a disadvantage for the distinctive features of living things for unimpaired adults. Results of a speeded feature verification study supported this prediction, as did a computational simulation in which networks mapped from orthography to semantics. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Evaluating reactivity to ecological momentary assessment during smoking cessation.

Ecological momentary assessment (EMA) consists of assessing phenomena in real time in the natural environment. EMA allows for more fine-grained analyses of addictive behavior and minimizes threats to internal validity, such as recall biases and errors. However, because of the intensive monitoring involved in EMA, measurement reactivity is a concern. To test whether EMA with palmtop personal computers induces reactivity, the authors compared smoking-related outcomes between smokers using EMA and those not using EMA during a quit attempt. The use of no-EMA control groups has been rare in reactivity investigations to date. The EMA protocol included event-contingent assessments (smoking episodes, urge episodes) and random assessments. Outcomes included biologically confirmed abstinence and self-report measures of withdrawal, self-efficacy, motivation, affect, and temptations. Participants were smokers motivated to quit (N = 96). They were randomized to 1 of 3 groups: EMA for the week preceding a planned quit date, EMA for the week following the quit date, and no EMA. Abstinence rates did not differ between the groups at Day 7 or at Day 28 postcessation. For the 20 subscales assessed at each of 3 assessment times, there were significant differences between participants with and without EMA experience for 3 subscales at the 1st of 3 assessment times, and significant differences for 3 different subscales at the 3rd assessment time. These differences suggest some reactivity to EMA, although the inconsistent pattern across time indicates that further research is needed to definitively conclude that EMA induces reactivity. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Fugitive Diffusion Barrier for Integration of Sol-Gel-Derived Lead Titanate with Oxidized Silicon Substrates

The crystalline phase development and microstructural changes with heating of sol-gel-derived lead titanate (PT) particles and films on silica with and without a fugitive (or removable) diffusion barrier layer were investigated. Amorphous gel-derived PT particles were deposited on SiO₂-coated TEM grids with and without polyimide (PI) or carbon barrier layers between SiO₂ and PT. TEM analysis showed that PI or carbon barriers prevented reaction between the gel-derived PT particles and SiO₂. PT particles crystallize and then the PI or carbon film decomposes. Sol-gel-derived PT films were deposited on oxidized Si substrates (Si/SiO₂) with and without a PI barrier layer. Perovskite PT films were prepared on Si/SiO₂ substrates with a PI barrier; however, some porosity remained in the films. Identically prepared films without the PI barrier formed a mixture of pyrochlore and perovskite. X-ray photoelectron spectroscopy results indicate that the PI film pre- vents the diffusion of Si into the PT film.     

Rheological Property and Stress Development during Drying of Tape-Cast Ceramic Layers

Rheological property and stress development of tape-cast ceramic layers derived from nonaqueous alumina (A1₂O₃)-poly(vinyl butyral) (PVB) suspensions were observed during drying. Casting suspensions exhibited strong shear-thinning behavior, with a low shear Newtonian plateau apparent viscosity >10² Pa^.s. The apparent suspension viscosity displayed a power-law dependence on the A1₂O₃ volume fraction during the initial stage of drying (<30% solvent loss). Stress development, measured by a cantilever deflection method, and parallel weight loss measurements were performed during the drying of tape-cast layers and pure binder coatings. Maximum drying stresses (σ_max) of 1.37-0.77 MPa were observed for plasticized tapes cast at gap heights of 150-400 μm. In contrast, nonplasticized tapes of similar thickness displayed a more gradual stress increase, with σ_max values approximately an order of magnitude higher than their plasticized counterparts. The stress histories of the corresponding binder coatings were quite similar to the tape-cast layers, albeit slightly lower σ _max values were observed. Stresses decayed beyond σ_max with a logarithmic time dependence to an almost constant value of 0.2-0.4 MPa for the plasticized tapes. Based on these observations, process methodologies have been offered to minimize stress development and retention in tape-cast ceramic layers     

The 3D Chinese head and face modeling

Perfect fit for people has always been a target for product design. Designers commonly use traditional anthropometric dimensions for 3D product design thus creating a lot of fitting problems when dealing with the complexities of human body shapes. The development of recent 3D anthropometric survey has created an opportunity for complex shape analysis on human model by collecting 3D scan data. Using 3D point cloud data from the SizeChina survey, a methodology of creating a homologous 3D head and face model was demonstrated in this study. Anatomical and virtual landmarks, and surface modeling algorithm based on point cloud data were applied in building the model. The head and face models for all scans had the same amount of vertices with consistent features. The average Chinese models showed obvious differences between male and female. The variations of head and face shapes were analyzed using Principal Component Analysis and the results showed that the largest variations among people were general size, especially for width and depth. However face height, forehead, back of the head, chin and jaw area were also important when describing the 3D shape. The results from this study may be useful in the design of head and facial products.     

Yesterday and tomorrow: Development of early understanding of the terms.

Data from 90 2-, 3-, and 4-yr-old children indicate that there is a differential pattern of comprehension of the terms "yesterday" and "tomorrow" among the 3 age groups. Findings also suggest that the Ss learned the terms in an asymmetrical manner, with "yesterday" being understood as having 2 referential aspects (i.e., a time other than this day and past time) and "tomorrow" being understood only in terms of future reference. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The Morning After: Limit Violations and the Self-Regulation of Alcohol Consumption.

The authors examined whether the reciprocal relationship between alcohol consumption and distress unfolded over time in 2 samples of social drinkers. Participants monitored their alcohol intake and their cognitive and emotional responses to that drinking on hand-held computers. On mornings after drinking, those who had violated their self-imposed limits the day before reported more guilt, even after controlling for acute negative symptoms of drinking and amount consumed. Reciprocally, guilt led to poorer self-regulation of alcohol intake: Greater distress over alcohol consumption was linked to more intake, intoxication, and more limit violations. Individual differences moderated the relationships among limit violations, distress, and drinking. Consistent with the limit violation effect, violating a limit produced distress over consumption among social drinkers, and they responded to that distress by drinking more. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

CAR T Cell Therapy in Hematological Malignancies: Implications of the Tumor Microenvironment and Biomarkers on Efficacy and Toxicity

Chimeric antigen receptor (CAR) T cell therapy has ushered in a new era in cancer treatment. Remarkable outcomes have been demonstrated in patients with previously untreatable relapsed/refractory hematological malignancies. However, optimizing efficacy and reducing the risk of toxicities have posed major challenges, limiting the success of this therapy. The tumor microenvironment (TME) plays an important role in CAR T cell therapy’s effectiveness and the risk of toxicities. Increasing research studies have also identified various biomarkers that can predict its effectiveness and risk of toxicities. In this review, we discuss the various aspects of the TME and biomarkers that have been implicated thus far and discuss the role of creating scoring systems that can aid in further refining clinical applications of CAR T cell therapy and establishing a safe and efficacious personalised medicine for individuals.