Human C4b-binding protein (C4BP) functions as a cofactor to factor I in the degradation of C4b and accelerates the decay rate of the C4b2a complex. In this study we describe a monoclonal antibody directed against the alpha-chain of C4BP that inhibits the binding of C4b to C4BP. In order to identify the structural domain of the alpha-chain of C4BP that interacts with C4b, tryptic fragments of C4BP were generated. Amino acid sequence analysis of the fragments revealed that the residues Ser333-Arg356 of the alpha-chain of C4BP contain the epitope of this antibody, and as a consequence, that this part of the alpha-chain of C4BP is likely to be involved in the interaction with C4b. 相似文献
Wafer Scale Integration promises radical improvements in the performance of digital signal processing systems. This paper describes the design of a radix-8 systolic (pipeline) fast Fourier transform processor for implementation with wafer scale integration. By the use of the radix-8 FFT butterfly wafer that is currently under development, continuous data rates of 160 MSPS are anticipated for FFTs of up to 4096 points with 16-bit fixed point data. 相似文献
A two-dimensional cross-section finite difference model is presented to simulate density dependent leachate migration in leaky aquifers. Unlike existing models, a new approach is adopted to couple the groundwater-flow equation and the hydrodynamic dispersion equation with the elimination of the intermediate step of calculating velocities. The concept of the reference density is employed, permitting increased accuracy (over pressure-based models) in the representation of the transport process. The model is then used to study the effect of several hydraulic and transport parameters on the flow pattern and plume migration which are found to be very sensitive to most of these parameters. Equiconcentration and equipotential lines are overlapped to provide a better understanding of the coupling effect. 相似文献
Because of very different heating rates in hot‐tool and vibration welding, and the higher weld pressures used in vibration welding inducing more squeeze flow, the weld zones in these two processes see very different flows and cooling rates, resulting in different morphologies. The weld morphologies of bisphenol‐A polycarbonate (PC) and poly(butylene terephthalate) (PBT) for these two processes are discussed in relation to these differences. The thickness of the heat‐affected zone (HAZ) in hot‐tool welds increases with the melt time; this zone is thicker than in vibration welds. The HAZ thickness in hot‐tool welds increases from the center toward the edges. The HAZ thickness is more uniform in vibration welds. Hot‐tool welds of PC have large numbers of bubbles around the central plane; the bubble size increases from the center to the edges. PC vibration welds do not have bubbles except near the edges. Both hot‐tool and vibration welds of PBT do not have bubbles. The morphology of the HAZ in PBT is very different in hot‐tool and vibration welds. In hot‐tool welds, the resolidified material consists of a sandwich structure in which two thin layers with very small crystallites surround a thicker central layer in which the spherulites are almost as large as in the original molded material. In vibration welds, the HAZ has large crystallinity gradients across the weld zone as well as squeeze‐flow induced distortion of the small spherulites. 相似文献
The effects of microstructure on the tensile properties and deformation behavior of a binary Ti-48Al gamma titanium aluminide
were studied. Tensile-mechanical properties of samples with microstructures ranging from near γ to duplex to fine grained, near- and fully-lamellar were determined at a range of temperatures, and the deformation structures
in these characterized by transmission electron microscopy (TEM). Microstructure was observed to exert a strong influence
on the tensile properties, with the grain size and lamellar volume fraction playing connected, but complex, roles. Acoustic
emission response monitored during the tensile test revealed spikes whose amplitude and frequency increased with an increase
in the volume fraction of lamellar grains in the microstructure. Analysis of failed samples suggested that microcracking was
the main factor responsible for the spikes, with twinning providing a minor contribution in the near-lamellar materials. The
most important factor that controls ductility of these alloys is grain size. The ductility, yield stress, and work-hardening
rate of the binary Ti-48Al alloy exhibit maximum values between 0.50 and 0.60 volume fraction of the lamellar constituent.
The high work-hardening rate, which is associated with the low mobility of dislocations, is the likely cause of low ductility
of these alloys. In the near-γ and duplex structures, slip by motion of 1/2<110] unit dislocations and twinning are the prevalent deformation modes at room
temperature (RT), whereas twinning is more common in the near- and fully-lamellar structures. The occurrence of twinning is
largely dictated by the Schmid factor. The 1/2<110] unit dislocations are prevalent even for grain orientations for which
the Schmid factor is higher for <101] superdislocations, though the latter are observed in favorably oriented grains. The
activity of both of these systems is responsible for the higher ductility at ambient temperatures compared with Al-rich single-phase
γ alloys. A higher twin density is observed in lamellar grains, but their propagation depends on the orientation and geometry
of the individual γ lamellae. The increase in ductility at high temperatures correlates with increased activity of 1/2<110] dislocations (including
their climb motion) and twin thickening. The role of microstructural variables on strength, ductility, and fracture are discussed.
This article is based on a presentation made in the symposium entitled “Fundamentals of Structural Intermetallics,” presented
at the 2002 TMS Annual Meeting, February 21–27, 2002, in Seattle, Washington, under the auspices of the ASM and TMS Joint
Committee on Mechanical Behavior of Materials. 相似文献
A simulation-optimization procedure is presented for evaluating the extent of interbasin transfer of water in the Peninsular
Indian river system consisting of 15 reservoirs on four river basins. A system-dependent simulation model is developed incorporating
the concept of reservoir zoning to facilitate releases and transfers. The simulation model generates a larger number of solutions
which are then screened by the optimization model. The Box complex nonlinear programming algorithm is used for the optimization.
The performance of the system is evaluated through simulation with the optimal reservoir zones with respect to four indices,
reliability, resiliency, vulnerability and deficit ratio. The results indicate that by operating the system of 15 reservoirs
as a single unit the existing utilization of water may be increased significantly. 相似文献
Late occurrence of cytomegalovirus (CMV) disease after day 100 after bone marrow transplantation has become an increasing problem; whether a quantitative measurement of CMV DNA in plasma by polymerase chain reaction (P-PCR) could be predictive of such disease was investigated. In a prospective study, 117 subjects undergoing allogeneic marrow transplantation were followed for 120 days with weekly CMV blood cultures, with day 35 bronchoalveolar lavage CMV cultures, with weekly CMV P-PCR, and with clinical follow-up for an additional 1-2 years. Despite preemptive ganciclovir, CMV disease occurred in 9% of subjects, with a median time of onset of 176 days. Quantitative CMV P-PCR was associated with the late development of CMV disease (P = .01). Of 43 subjects with positive P-PCR results, 23% developed CMV disease, but no disease occurred in the 74 subjects with negative P-PCR (P < .001), despite the fact that 22% had CMV isolated from lung lavage fluid and 32% had CMV isolated from blood. 相似文献
The extensively utilized tool to detect novel coronavirus (COVID-19) is a real-time polymerase chain reaction (RT-PCR). However, RT-PCR kits are costly and consume critical time, around 6 to 9 hours to classify the subjects as COVID-19(+) or COVID-19(-). Due to the less sensitivity of RT-PCR, it suffers from high false-negative results. To overcome these issues, many deep learning models have been implemented in the literature for the early-stage classification of suspected subjects. To handle the sensitivity issue associated with RT-PCR, chest CT scans are utilized to classify the suspected subjects as COVID-19 (+), tuberculosis, pneumonia, or healthy subjects. The extensive study on chest CT scans of COVID-19 (+) subjects reveals that there are some bilateral changes and unique patterns. But the manual analysis from chest CT scans is a tedious task. Therefore, an automated COVID-19 screening model is implemented by ensembling the deep transfer learning models such as Densely connected convolutional networks (DCCNs), ResNet152V2, and VGG16. Experimental results reveal that the proposed ensemble model outperforms the competitive models in terms of accuracy, f-measure, area under curve, sensitivity, and specificity.
Partially crystalline Si3N4, with nanosized crystals and a specific surface area greater than 200 m2/g, is obtained by pyrolysis of a commercially available vinylic polysilane in a stream of anhydrous NH3 to 1000°C. This polymer does not contain N initially. Crystallization to high-purity α-Si3N4 proceeds with additional heating above 1400°C under N2. The changes in crystallinity, powder morphology, infrared spectra, and elemental compositions, for samples annealed from 1000° to 1600°C under N2, are consistent with an amorphous-to-crystalline transformation. Although macroscopic consolidation and local densification occur at 1400°C, volatilization and accompanying weight loss limit bulk densification. The effect of temperature on specific surface area is examined and related to the sintering process. These results are applicable to pyrolysis, decomposition, and crystallization studies of ceramics synthesized by polymeric precursor routes. 相似文献