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排序方式: 共有1036条查询结果,搜索用时 15 毫秒
1.
Virginia Veronica Visconti Ida Cariati Simona Fittipaldi Riccardo Iundusi Elena Gasbarra Umberto Tarantino Annalisa Botta 《International journal of molecular sciences》2021,22(8)
DNA methylation is one of the most studied epigenetic mechanisms that play a pivotal role in regulating gene expression. The epigenetic component is strongly involved in aging-bone diseases, such as osteoporosis and osteoarthritis. Both are complex multi-factorial late-onset disorders that represent a globally widespread health problem, highlighting a crucial point of investigations in many scientific studies. In recent years, new findings on the role of DNA methylation in the pathogenesis of aging-bone diseases have emerged. The aim of this systematic review is to update knowledge in the field of DNA methylation associated with osteoporosis and osteoarthritis, focusing on the specific tissues involved in both pathological conditions. 相似文献
2.
Alison Willette Benjamin Fallen Hem Bhandari Carl Sams Feng Chen Virginia Sykes Chris Smallwood Kristin Bilyeu Zenglu Li Vincent Pantalone 《Journal of the American Oil Chemists' Society》2021,98(8):861-869
Soybean oil hydrogenation alters the linolenic acid molecule to prevent the oil from becoming rancid, however, health reports have indicated trans-fat caused by hydrogenation, is not generally regarded as safe. Typical soybeans contain approximately 80 g kg−1 to 120 g kg−1 linolenic acid and 240 g kg−1 of oleic acid. In an effort to accommodate the need for high-quality oil, the United Soybean Board introduced an industry standard for a high oleic acid greater than 750 g kg−1 and linolenic acid less than 30 g kg−1 oil. By combing mutations in the soybean plant at four loci, FAD2-1A and FAD2-1B, oleate desaturase genes and FAD3A and FAD3C, linoleate desaturase genes, and seed oil will not require hydrogenation to prevent oxidation and produce high-quality oil. In 2017 and 2018, a study comparing four near-isogenic lines across multiple Tennessee locations was performed to identify agronomic traits associated with mutations in FAD3A and FAD3C loci, while holding FAD2-1A and FAD2-1B constant in the mutant (high oleic) state. Soybean lines were assessed for yield and oil quality based on mutations at FAD2-1 and FAD3 loci. Variations of wild-type and mutant genotypes were compared at FAD3A and FAD3C loci. Analysis using a generalized linear mixed model in SAS 9.4, indicated no yield drag or other negative agronomic traits associated with the high oleic and low linolenic acid genotype. All four mutations of fad2-1A, fad2-1B, fad3A, and fad3C were determined as necessary to produce a soybean with the new industry standard (>750 g kg−1 oleic and <30 g kg−1 linolenic acid) in a maturity group-IV-Late cultivar for Tennessee growers. 相似文献
3.
Joe Virginia 《电子产品世界》2006,(4):67-68
今天的液晶显示器(LCD)所达到的性能和图像质量在仅仅几年之前还是梦想,LCD显示器在几个相关的前沿领域不断发展.小型LCD体现得比其他任何领域都更为真切.手机行业的激烈竞争和螺旋式上升的用户需求正在驱动显示技术去满足融合的需要,即移动通信与移动计算和/或移动娱乐的融合. 相似文献
4.
Serum total cholesterol, high density lipoprotein (HDL) cholesterol, and triglyceride levels were studied in healthy male
and female subjects consuming for one-week periods a diet of conventional food (CF) providing 42% of energy as fat, principally
butter fat, and then in random order nutritionally complete, defined formula diets of moderate (32%) to very low (1%) fat
content. Compared to CF, the formula with 32% of energy as corn oil lowered serum cholesterol by 25% and the ratio of total
to HDL-cholesterol by 13%. Low (9%) and very low (1–3%) fat formulas reduced HDL-cholesterol by as much as 40%, raised the
total: HDL-cholesterol ratio by about 20% and raised serum triglyceride levels by as much as 100%. When low and very low fat
formulas were ingested for three weeks, these effects persisted although maximal responses occurred during the first week.
These results demonstrated that a moderate fat formula diet with a high P/S ratio had a more favorable effect on serum lipid
levels than various low fat formulas. Low fat conventional food diets should be studied in long-term controlled metabolic
experiments before such diets are recommended to the general population for coronary heart disease or cancer prevention. 相似文献
5.
Ryba Nancy L.; Cooper Virginia G.; Zapf Patricia A. 《Canadian Metallurgical Quarterly》2003,34(5):499
What is the current standard of practice for evaluations of juvenile competence to stand trial (JCST)? The present study surveyed psychologists regarding the practices used when conducting JCST evaluations. Respondents rated the importance of 17 elements that might be included in a JCST evaluation report. Of these elements, 7 were considered essential by 70% or more of respondents, with 9 additional elements rated as either essential or recommended. A majority of respondents felt that the use of psychological and forensic instruments was important. A list of tests used is provided, and the implications for the development of standards and policy are discussed to provide practitioners with additional knowledge that will help to further the state of the discipline. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
6.
7.
Berninger Virginia W.; Vaughan Katherine; Abbott Robert D.; Brooks Allison; Abbott Sylvia P.; Rogan Laura; Reed Elizabeth; Graham Steve 《Canadian Metallurgical Quarterly》1998,90(4):587
Poor spellers in 2nd grade (n?=?128) participated in 24 20-min sessions that included (a) direct instruction in the alphabet principle (most frequent phoneme-spelling connections); (b) modeling of different approaches, singly and in combination, for developing connections between spoken and written words for 48 words ordered by sound-spelling predictability; and (c) practice in composing. Results of this multilayered intervention showed that (a) more than 1 way of developing sound-spelling connections is effective in teaching spelling but that after training in the alphabet principle, combining whole word and onset-rime training is most effective in achieving transfer of the alphabet principle across word contexts; (b) functional spelling units of not only a single letter but also 2 or more letters are important in beginning spelling; and (c) training in spelling transfers to composition and word recognition. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
8.
Nestor Paul G.; Faux Steven F.; McCarley Robert W.; Penhune Virginia; Shenton Martha E.; Pollak Seth; Sands Stephen F. 《Canadian Metallurgical Quarterly》1992,101(4):682
M. I. Possner's 1980 reaction time (RT) paradigm was used to examine the engagement and disengagement operations of visual selective attention in patients with schizophrenia. In the 1st experiment 14 medicated, chronic schizophrenic Ss (diagnosed by criteria of the Diagnostic and Statistical Manual of Mental Disorders [DSM-I]), and 15 age-matched normal and control Ss made a speeded response to a target preceded by a valid, and invalid, or no cue. Control Ss showed the expected advantage and disadvantage in RT for valid and invalid cues, which suggests intact engagement and disengagement operations. For schizophrenic Ss, valid cues also enhanced RT, but invalid cues did not slow RT. Similar results were found in the 2nd experiment. The failure of unpredictable, invalid cues to inhibit RT in chronic schizophrenia may be related to an abnormality in the disengagement operation of selective attention. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
9.
10.
AI Robles ML Rodriguez-Puebla AB Glick C Trempus L Hansen P Sicinski RW Tennant RA Weinberg SH Yuspa CJ Conti 《Canadian Metallurgical Quarterly》1998,12(16):2469-2474
Cyclin D1 is part of a cell cycle control node consistently deregulated in most human cancers. However, studies with cyclin D1-null mice indicate that it is dispensable for normal mouse development as well as cell growth in culture. Here, we provide evidence that ras-mediated tumorigenesis depends on signaling pathways that act preferentially through cyclin D1. Cyclin D1 expression and the activity of its associated kinase are up-regulated in keratinocytes in response to oncogenic ras. Furthermore, cyclin D1 deficiency results in up to an 80% decrease in the development of squamous tumors generated through either grafting of retroviral ras-transduced keratinocytes, phorbol ester treatment of ras transgenic mice, or two-stage carcinogenesis. 相似文献