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1.
目的:探索炎性疾病患者的乳酸林格氏液(Ringer's lactate,RL)液体动力学特征以及炎性生物标记物是否可以作为协变量影响RL分布和排泄。方法:本研究为前瞻性队列研究。选择40例美国麻醉医师分级(ASA)I-II级,腹腔镜下择期胆囊切除术(胆囊炎组,n=20)或者腹腔镜下急诊阑尾切除术(阑尾炎组,n=20)。所有患者麻醉诱导前开始输注RL,按15 mL/kg,35 min内输毕。采用酶联免疫(enzyme-linked immunosorbent assay,ELISA)方法测定血浆炎症(TNF-α,IL-10和CRP)或者内皮损伤生物标记物(syndecan-1,SDC-1);利用血红蛋白(Hb)稀释-时间曲线和尿量,使用Phoenix软件,采用非线性混合效应模型分析计算RL液体动力学参数和协变量的影响。结果:与胆囊炎组相比,阑尾炎组RL从组织间隙到血浆的转运速率常数(k21)显著降低(14×10-3min-1 versus 35×10-3min-1;P=0.012)。阑尾炎组C反应蛋白(CRP)升高[中位数38.1(1.8-143.6) μg/mL versus 1.3(0.1-159.0) μg/mL;P<0.001];与清醒状态相比,麻醉期间(输液开始后30~45 min),液体从中央室中到外周室的转运速率常数(k12)显著增加(57×10-3min-1 versus 32×10-3min-1;P<0.01)。清除速率常数(k10)降低90%(0.6×10-3min-1 versus 5.3×10-3min-1;P<0.001)。无论在清醒状态还是麻醉状态下低血压均能降低液体清除;炎症或者内膜损伤的生物标记物不能作为显著影响RL液体动力学参数的协变量。结论:阑尾炎或者胆囊炎患者术前输入液体后“炎症反应的生物标记物”不是RL的液体动力学的协变量,但是两组患者中,全身麻醉期间输入液体的清除率下降。 相似文献
2.
介绍了书籍装订热熔胶生产工艺及产品的技术指标,对1000t/a生产装置的投资与产品成本进行了核算。分析结果表明,总投资110万元,年利润达266万元。 相似文献
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Hadjem A. Lautru D. Dale C. Man Fai Wong Hanna V.F. Wiart J. 《Microwave Theory and Techniques》2005,53(1):4-11
This paper gives a first comparison of specific absorption rate (SAR) induced in a child-sized (CS) head and an adult head using a dual-band mobile phone. In the second study, the visible human head is considered and comparison of SAR induced in a CS or child-like (CL) head and an adult head using a dual-band mobile phone is given. All the peaks of average SAR over a mass of 10 and 1 g in the head and the power budget are determined in the two comparisons using the finite-difference time-domain method. The differences between the results for adult and CS or CL heads are given at 900 and 1800 MHz. No important differences are noted for the peak SAR averaged over 10 g (SAR10 g), between the two adult head models, as well as between the two child head models. The peak SAR10 g in the brain of the CS or CL head is slightly more significant than that for the adult one. 相似文献
5.
A. A. Man’kov Yu. V. Krasovitskii E. V. Arkhangel’skaya S. L. Kabargin D. B. Troshchenko N. N. Lobacheva V. P. Dobrosotskii 《Refractories and Industrial Ceramics》2008,49(3):225-228
Methods are proposed for designing interpolation models for the preliminary determination and subsequent forecasting of general
and fractional breakthrough coefficients for dust used with granular filters, as employed in energy-saving and high-performance
dust trapping from technological gases and ventilation discharges in refractory production. The models are supplied with nomograms,
which makes them widely suitable for experts working in environmental protection at refractory-producing organizations. The
main factors are identified that influence the performance. The results are of interest to experts in related areas of industry
such as building materials and engineering ceramics and so on.
Translated from Novye Ogneupory, No. 4, pp. 64–67, April, 2008. 相似文献
6.
用Tow-Thomas电路设计含有限非零传输零点有源滤波器的方法 总被引:4,自引:1,他引:3
Tow-Thomas电路是一种实现全极点滤波器的典型电路。本文给出了用Tow-Thoms电路设计含有限非零传输零点有源滤波器的方法,从而使Tow-Thomas电路可用于单片集成滤波器电路。而文中给出的公式可用于计算外接元件。设计实例表明了文中给出的计算公式的正确性。 相似文献
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Kerlavage A.R. FitzHugh W. Gladek A. Kelley J. Scott J. Shirley R. Sutton G. Man Wai-Chiu White O. Adams D. 《IEEE engineering in medicine and biology magazine》1995,14(6):710-717
The rapid advances in molecular biology have begun to shift many of the bottlenecks in genome research from the laboratory to the data analysis facility. The pace at which this has occurred creates a situation in which software development always has to catch up with the flow of data. Since such large-scale processes were not anticipated, the analysis infrastructure has not been fully established. Furthermore, most systems that have been built were designed by the biologists who collected the data. More recently, computer scientists, mathematicians, and engineers have taken an interest in this problem. This has had a positive effect, since it has created a tight synergy between the informatics and the biology. Several principles affected the design of the system developed at TIGR. Each of the sample preparation, sequencing, and analysis steps had to be managed, scheduled, and tracked. This information had to be made readily available to those who needed it for carrying out their tasks. Different skill levels of the users had to be taken into account. The degree of human intervention at each step had to be evaluated and built into the design. A mixed processing environment of Macintosh and Unix platforms had to be integrated. Most importantly, the system had to save time, reduce error, and ensure uniformity of the analysis and quality of the results. In the authors' experience, the tools they have built work well because of their early decisions as to which systems to use for development. The authors settled on a robust relational database management system (Sybase) and a portable development environment (C, C++) 相似文献
10.
A structured genetic algorithm (SGA) approach is developed for robust controller design based on the concept of an H∞ loop-shaping technique and the method of inequalities. Such an SGA is capable of simultaneously searching the orders and coefficients of the precompensator and postcompensator for the weighted plant. It is, therefore, not necessary to predefine the order of compensators as in usual practice. A multiple objective ranking approach is also incorporated so that the design criteria of extreme plants can be easily achieved. The effectiveness of such a technique is illustrated by a high-purity distillation column design example 相似文献