Construction of a key-dependent message secure symmetric encryption scheme in the ideal cipher model

Key-dependent message （KDM） security is an important security issue that has attracted much research in recent years. In this paper, we present a new construction of the symmetric encryption scheme in the the ideal cipher model （ICM）; we prove that our scheme is KDM secure against active attacks with respect to arbitrary polynomialtime challenge functions. Our main idea is to introduce a universal hash function （UHF） h as a random value for each encrypfion, and then use s = h（sk） as the key of the ideal cipher F, where sk is the private key of our symmetric encryption scheme. Although many other schemes that are secure against KDM attacks have already been proposed, in both the ideal standard models, the much more significance of our paper is the simplicity in which we implement KDM security against active attacks.     

酸碱影响下砂岩流变参数识别方法及敏感度

根据长期暴露在自然环境中的砂质岩体易遭受水及可溶离子化学侵蚀作用的事实,通过对相同浓度不同pH值CaCl₂试剂浸泡处理过的砂岩试件进行三轴剪切试验,根据试验结果选取符合试验规律的二阶简化广义Kelvin流变模型,按照定泊松比假设将其变形为三项应力状态。基于搜索模式的最小二乘方法（LSMPS）获取模型参数最优解,以均方根误差评价模型对各参数变化的敏感性程度。采用延迟时间评价砂岩在不同化学环境中达到稳定蠕变过程所需时间。通过搜索模式识别的模型参数能够使模型计算值与加载试验获得的实测值比较接近,表明该模型及其参数识别方法在确定受化学因素干扰下的砂岩流变特征比较适用。     

Interference Shaders of Thin Films

This paper presents a systematic study of light interferences at single thin films. Based on Fresnel's law, we have derived generic expressions of reflectance and transmittance for film interference, as well as specific expressions for free thin films and films coated on transparent or opaque objects. By combining film interference and volume absorption, we have obtained the reflectances and transmittances of film‐coated thin objects such as ribbons. Illumination models for all interference cases of single thin films are presented, and they have been implemented and tested for various structures and materials.     

Petromyzontidae-Biomimetic Multimodal Microneedles-Integrated Bioelectronic Catheters for Theranostic Endoscopic Surgery

Current catheter devices in minimally invasive surgery still possess limited functional options, lacking multimodal integration of both sensing and therapy. Catheter devices usually operate outside the tissue, incapable to detect intra-tissue biochemical information for accurate localization and assessment of lesions during surgery. Inspired by the feature and functions of Petromyzontidae, here a multimodal core-shell microneedles-integrated bioelectronic catheter (MNIBC) for tissue-penetrating theranostics in endoscopic surgery is developed. The microneedle (MN) device possesses individually addressable functionality at single-MN tip resolution, enabling multiplex functions (a total of 11 functions distributed in three types of catheters) including biochemical sensing, myoelectric modulation, electroporation, and drug delivery in a submucosal environment. The MNIBC is prepared through hybrid fabrication and dimensionality reduction strategies, where the MN electrodes are functionalized with an MXene-carbon nanotube (MXene-CNT)-based electron mediator, addressing the challenge of reduced electrode sensitivity on ultra-small MN tip. The functionalities of MNIBC are demonstrated both ex vivo and in vivo on anesthetized rabbits via laparoscopy, simulated cystoscopy, and laparotomy. The MNIBC can effectively detect intra-tissue biochemical signals in the bladder, and offers localized electroporation and intra-tissue drug delivery for precise treatments of lesions. The versatile features of the MNIBC present a highly advanced platform for precise surgeries.     

Cyt-C Mediated Mitochondrial Pathway Plays an Important Role in Oocyte Apoptosis in Ricefield Eel (Monopterus albus)

Apoptosis plays a key role in the effective removal of excessive and defective germ cells, which is essential for sequential hermaphroditism and sex change in vertebrates. The ricefield eel, Monopterus albus is a protogynous hermaphroditic fish that undergoes a sequential sex change from female to male. Previous studies have demonstrated that apoptosis is involved in sex change in M. albus. However, the apoptotic signaling pathway is unclear. In the current study, we explored the underlying mechanism of apoptosis during gonadal development and focused on the role of the mitochondrial apoptosis signaling pathway in sex change in M. albus. Flow cytometry was performed to detect apoptosis in gonads at five sexual stages and ovary tissues exposed to hydrogen peroxide (H₂O₂) in vitro. Then the expression patterns of key genes and proteins in the mitochondrial pathway, death receptor pathway and endoplasmic reticulum (ER) pathway were examined. The results showed that the apoptosis rate was significantly increased in the early intersexual stage and then decreased with the natural sex change from female to male. Quantitative real-time PCR revealed that bax, tnfr1, and calpain were mainly expressed in the five stages. ELISA demonstrated that the relative content of cytochrome-c (cyt-c) in the mitochondrial pathway was significantly higher than that of caspase8 and caspase12, with a peak in the early intersexual stage, while the levels of caspase8 and caspase12 peaked in the late intersexual stage. Interestingly, the Pearson’s coefficient between cyt-c and the apoptosis rate was 0.705, which suggests that these factors are closely related during the gonadal development of M. albus. Furthermore, the cyt-c signal was found to be increased in the intersexual stage by immunohistochemistry. After incubation with H₂O₂, the mRNA expression of mitochondrial pathway molecules such as bax, apaf-1, and caspase3 increased in ovary tissues. In conclusion, the present results suggest that the mitochondrial apoptotic pathway may play a more important role than the other apoptotic pathways in sex change in M. albus.     

Expression Patterns and Gonadotropin Regulation of the TGF-β II Receptor (Bmpr2) during Ovarian Development in the Ricefield Eel Monopterus albus

Bmpr2 plays a central role in the regulation of reproductive development in mammals, but its role during ovarian development in fish is still unclear. To ascertain the function of bmpr2 in ovarian development in the ricefield eel, we isolated and characterized the bmpr2 cDNA sequence; the localization of Bmpr2 protein was determined by immunohistochemical staining; and the expression patterns of bmpr2 in ovarian tissue incubated with FSH and hCG in vitro were analyzed. The full-length bmpr2 cDNA was 3311 bp, with 1061 amino acids encoded. Compared to other tissues, bmpr2 was abundantly expressed in the ovary and highly expressed in the early yolk accumulation (EV) stages of the ovary. In addition, a positive signal for Bmpr2 was detected in the cytoplasm of oocytes in primary growth (PG) and EV stages. In vitro, the expression level of gdf9, the ligand of bmpr2, in the 10 ng/mL FSH treatment group was significantly higher after incubation for 4 h than after incubation for different durations. However, bmpr2 expression in the 10 ng/mL FSH treatment group at 2 h, 4 h and 10 h was significantly lower. Importantly, the expression level of bmpr2 and gdf9 in the 100 IU/mL hCG group had similar changes that were significantly decreased at 4 h and 10 h. In summary, Bmpr2 might play a pivotal role in ovarian growth in the ricefield eel, and these results provide a better understanding of the function of bmpr2 in ovarian development and the basic data for further exploration of the regulatory mechanism of gdf9 in oocyte development.     

设计院协同设计平台浅谈

本文主要介绍了计算机协同技术在设计行业中的应用,从目前设计行业在协同工作中存在的一些问题到怎样使用协同设计技术来有效管理和深层应用,并简单列举了目前常见的一些协同设计技术,并对各自的特点做了简单介绍和对比。     

虚拟施工在设计院的应用浅谈

本文主要根据镍钴设计院和建设单位的工程项目现状,针对当前传统的设计方法无法满足需要的实际问题,运用BIM技术创建的虚拟建筑模型包含了建筑的所有信息,通过应用虚拟现实、计算机仿真等技术对实际施工过程进行计算机模拟和分析, 达到对施工过程的事前控制和动态管理, 以优化施工方案和风险控制     

风城油田齐古组油砂细观结构和渗流特征

为确定风城油田侏罗系齐古组油砂的细观结构和渗流特征,利用微米CT获得的灰度图像,在传统图像分割方法的基础上,提出了适用于油砂的3种介质图像分割方法,并采用物理实验法获得了油砂数字岩心,构建了孔隙网络模型.研究表明:在构建油砂数字岩心时,需要在多孔介质图像二值化方法的基础上提出适用于油砂的3种介质图像分割方法,来区分油砂...     

穿心莲内酯对人神经胶质瘤U251细胞的抑制作用及机制研究

目的：应用网络药理学、生物信息学方法,结合体外实验,研究穿心莲内酯（Andrographolide,AND）对人神经胶质瘤U251细胞的抑制作用及机制。方法：通过网络药理学手段,根据AND的结构预测其神经胶质瘤相关靶点。应用生物信息学方法,筛选出枢纽基因进行基因本体（Gene Ontology,GO）分子功能及基因组百科全书（Kyoto Encyclopedia of Genes and Genomes,KEGG）富集分析以确定与其相关的信号通路,再进行分子对接,研究AND与上述靶点的结合活性,最后进行基因富集分析（Gene Set Enrichment Analysis,GSEA）,通过神经胶质瘤样本和正常样本的比较,分析枢纽基因的表达差异并获得其Kaplan-Meier生存曲线。在上述基础上,在人源神经胶质瘤细胞U251观察AND对其生长的影响及形态变化,并检测AND在蛋白质水平对PI3K/AKT通路的影响。结果：通过网络药理学手段获得AND的40个神经胶质瘤相关靶点,并应用生物信息学方法筛选出10个枢纽基因,AND与其有较强的结合活性。GO、KEGG富集分析结果显示,上述枢纽基因...