Dissociation between the potency and reversibility of the insulinotropic action of two meglitinide analogues

The non-sulphonylurea hypoglycaemic agent repaglinide is about one order of magnitude less potent, in terms of insulinotropic efficiency, than S3075, another meglitinide analogue. In the present study, the effects of these two drugs upon 86Rb outflow, 45Ca efflux and insulin release from prelabelled rat pancreatic islets were investigated in a perifusion system. At a concentration of 10 microM, which is sufficient to evoke a maximal secretory response in incubated islets, both agents inhibited 86Rb efflux from islets perifused in the absence of D-glucose, and stimulated both 45Ca efflux and insulin release from islets perifused in the presence of 6 mM D-glucose. The stimulation of 45Ca efflux from prelabelled islets was suppressed in the absence of extracellular Ca2+. The cationic and secretory response to repaglinide differed, however, from that evoked by S3075, in persisting for at least 20 min after removal of the drug from the perifusion medium, whilst the changes in 86Rb outflow, 45Ca efflux and insulin release caused by S3075 were rapidly reversible. These findings indicate that there is no parallel between the insulinotropic efficiency of distinct meglitinide analogues, and the reversibility of their functional effects. Since a comparable dissociation was recently documented in the case of hypoglycaemic sulphonylureas, the present observations reinforce the view that distinct molecular determinants may rule the relative insulinotropic potency of sulphonylureas and structurally related meglitinide analogues, on one hand, and the reversibility of their biological action, on the other hand.     

Scientometrics of the international journal Scientometrics

An analysis of 1317 papers published in first fifty volumes during 1978 to 2001 of the international journal Scientometrics indicates the heterogeneity of the field with emphasis on scientometric assessment. The study indicates that the US share of papers is constantly on the decline while that of the Netherlands, India, France and Japan is on the rise. The research output is highly scattered as indicated by the average number of papers per institution. The scientometric output is dominated by the single authored papers, however, multi-authored papers are gaining momentum. Similar pattern has been observed for domestic and international collaboration.     

Fuzzy Bayesian reliability and availability analysis of production systems

To have effective production planning and control, it is necessary to calculate the reliability and availability of a production system as a whole. Considering only machine reliability in the calculations would most likely result unmet due dates. In this study, a new modelling approach for determining the reliability and availability of a production system is proposed by considering all the components of the system and their hierarchy in the system structure. Components of a production system are defined as production processes; components of the processes are defined as sub-processes. In this hierarchical structure we could model all kinds of failures such as material and supply, management and personnel, and machine and equipment. In the analysis, a fuzzy Bayesian method is used to quantify the uncertainties in the production environment. The suggested modelling approach is illustrated on an example. In the example, also a separate reliability and availability analysis is conducted which only considered machine failures, and the results of both analyses are compared.     

Ascorbic acid imprinted polymer-modified graphite electrode: A diagnostic sensor for hypovitaminosis C at ultra trace ascorbic acid level

A new kind of molecularly imprinted polymer-modified graphite electrode was fabricated by “grafting-to” approach, incorporating sol–gel technique, for the detection of acute deficiency in serum ascorbic acid level (SAAL), manifesting hypovitaminosis C. The modified electrode exhibited ascorbic acid (AA) oxidation at less positive potential (0.0 V) than the earlier reported methods, resulting in a limit of detection as low as 6.13 ng mL⁻¹ (RSD = 1.2%, S/N = 3). The diffusion coefficient (1.096 × 10⁻⁵ cm² s⁻¹), rate constant (7.308 s⁻¹), and Gibb's free energy change (−12.59 kJ mol⁻¹) due to analyte adsorption, were also calculated to explore the kinetics of AA oxidation. The proposed sensor was found to enhance sensitivity substantially so as to detect ultra trace level of AA in the presence of other biologically important compounds (dopamine, uric acid, etc.), without any cross interference and matrix complications from biological fluids and pharmaceutical samples.     

Mobile multi-view object image search

High user interaction capability of mobile devices can help improve the accuracy of mobile visual search systems. At query time, it is possible to capture multiple views of an object from different viewing angles and at different scales with the mobile device camera to obtain richer information about the object compared to a single view and hence return more accurate results. Motivated by this, we propose a new multi-view visual query model on multi-view object image databases for mobile visual search. Multi-view images of objects acquired by the mobile clients are processed and local features are sent to a server, which combines the query image representations with early/late fusion methods and returns the query results. We performed a comprehensive analysis of early and late fusion approaches using various similarity functions, on an existing single view and a new multi-view object image database. The experimental results show that multi-view search provides significantly better retrieval accuracy compared to traditional single view search.     

An adaptive least squares channel estimation based on conjugate gradient approach for multipath fading CDMA systems

Multiple access interference (MAI) is the main factor affecting the performance of channel estimation techniques for code division multiple access (CDMA) systems. Although, several multi-user channel estimation algorithms have been proposed to mitigate MAI, these algorithms require high computational complexities. In this paper, we address the problem of iterative least squares (LS) mobile channel estimation at high channel efficiency that requires a short training sequence along with the spreading sequences. We employ an efficient iterative method based on conjugate gradient (CG) algorithm to reduce the computational complexity of the estimation method. Computer simulations illustrate that the proposed method performs almost identical to the exact LS estimate for reasonable training lengths.     

Automated construction of fuzzy event sets and its application toactive databases

Fuzzy sets and fuzzy logic research aims to bridge the gap between the crisp world of maths and the real world. Fuzzy set theory was applied to many different areas, from control to databases. Sometimes the number of events in an event-driven system may become very high and unmanageable. Therefore, it is very useful to organize the events into fuzzy event sets also introducing the benefits of fuzzy set theory. All the events that have occurred in a system can be stored in event histories which contain precious hidden information. We propose a method for automated construction of fuzzy event sets out of event histories via data mining techniques. The useful information hidden in the event history is extracted into a matrix called sequential proximity matrix. This matrix shows the proximities of events and it is used for fuzzy rule execution via similarity based event detection and construction of fuzzy event sets. Our application platform is active databases. We describe how fuzzy event sets can be exploited for similarity based event detection and fuzzy rule execution in active database systems     

Thermoelectric Properties of Two-Phase PbTe with Indium Inclusions

The thermoelectric figure of merit (zT) can be increased by introduction of additional interfaces in the bulk to reduce the thermal conductivity. In this work, PbTe with a dispersed indium (In) phase was synthesized by a matrix encapsulation technique for different In concentrations. x-Ray diffraction analysis showed single-phase PbTe with In secondary phase. Rietveld analysis did not show In substitution at either the Pb or Te site, and this was further confirmed by room-temperature Raman data. Low-magnification (~1500×) scanning electron microscopy images showed micrometer-sized In dispersed throughout the PbTe matrix, while at high magnification (150,000×) an agglomeration of PbTe particles in the hot-pressed samples could be seen. The electrical resistivity (ρ) and Seebeck coefficient (S) were measured from 300 K to 723 K. Negative Seebeck values showed all the samples to be n-type. A systematic increase in resistivity and higher Seebeck coefficient values with increasing In content indicated the role of PbTe-In interfaces in the scattering of electrons. This was further confirmed by the thermal conductivity (κ), measured from 423 K to 723 K, where a greater reduction in the electronic as compared with the lattice contribution was found for In-added samples. It was found that, despite the high lattice mismatch at the PbTe-In interface, phonons were not scattered as effectively as electrons. The highest zT obtained was 0.78 at 723 K for the sample with the lowest In content.     

Effect of supercritical CO2 extraction process parameters on oil yield and pigment content from by‐product hemp cake

This research gives an insight into the possibility of exploiting the one of the food industry's by‐products – pressed hemp cake. The complete recovery of oil from pressed hemp cake was achieved. Residual oil that remained in cake after pressing was extracted with supercritical CO₂ by applying different process parameters. Optimal extraction conditions were determined using response surface methodology. Total pigment contents of the oils obtained were determined. Extraction pressure had the most significant influence on yield and pigment content of extracted hemp cake oil. Depending on the pressure, the chlorophyll a content ranged from 101.11 to 378.28 mg kg^?1 and chlorophyll b from 65.14 to 189.78 mg kg^?1, while total carotene content was in the range from 33.58 to 132.67 mg kg^?1. The remaining oil in pressed hemp cake after supercritical CO₂ extraction was determined to be 0.56 ± 0.08% and the defatted cake was rich in proteins and fibre.