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1.
The application of the eXtended finite element method (X-FEM) to thermal problems with moving heat sources and phase boundaries
is presented. Of particular interest is the ability of the method to capture the highly localized, transient solution in the
vicinity of a heat source or material interface. This is effected through the use of a time-dependent basis formed from the
union of traditional shape functions with a set of evolving enrichment functions. The enrichment is constructed through the
partition of unity framework, so that the system of equations remains sparse and the resulting approximation is conforming.
In this manner, local solutions and arbitrary discontinuities that cannot be represented by the standard shape functions are
captured with the enrichment functions. A standard time-projection algorithm is employed to account for the time-dependence
of the enrichment, and an iterative strategy is adopted to satisfy local interface conditions. The separation of the approximation
into classical shape functions that remain fixed in time and the evolving enrichment leads to a very efficient solution strategy.
The robustness and utility of the method is demonstrated with several benchmark problems involving moving heat sources and
phase transformations.
Received 20 May 2001 / Accepted 19 December 2001 相似文献
2.
Phosphatidylsulfocholine (PSC), the sulfonium analogue of phosphatidylcholine (PC), occurs naturally in some diatoms. The
replacement of the −N+(CH3)3 group by a −S+(CH3)2 results in an increase in the polar head group size in PSC relative to that of PC, consistent with the observed increase
in permeability of PSC bilayers towards urea. It was of interest to see whether replacement of the −N+(CH3)3 group in platelet activating factor (PAF) by an −S+(CH3)2 group leads to any change in platelet aggregation or other physiological activity. Synthesis of the sulfonium analogue of
PAF was carried out by suitable modifications of known procedures. The PAF-sulfonium analogue was found to have almost the
same platelet aggregating activity as PAF itself, in the concentration range 1–20 μM, but a much lower activity in the range
0.01–1 μM. The analogue had little or no effect on the platelet aggregation activity of PAF when added in the concentration
range 0.01–1 μM and had about half the hypotensive activity of PAF towards hypertensive CDF male rats. The sulfonium analogue,
however, was much more cytotoxic to HL-60 cells than PAF itself, in the concentration range 0–15 μM; replacement of the acetate
group by a benzyl group increased the cytotoxicity to the level of that of the methoxy analogue of PAF. Thus, replacement
of the −N+(CH3)3 group by a −S+(CH3)2 group in the polar head group region of PAF results in a relatively small change in its platelet aggregation activity and
a decrease in its hypotensive activity, but greatly increases its antitumor activity.
Based on a paper presented at the Third International Conference on Platelet-Activating Factor and Structurally Related Alkyl
Ether Lipids, Tokyo, Japan, May 8–12, 1989. 相似文献
3.
R. Blancon J. J. Martinez-vega G. Merle G. Camino A. Ya. Polishchuk M. P. Luda M. Revellino 《Polymer Engineering and Science》1997,37(10):1722-1731
The physicochemical aging for parts of Sheet Molding Compound should be considered for their lifetime management and reusability. This material has a complex morphology and contains porosity due to the process and to shrinkage compensation. This SMC study has two complementary approaches. One describes the morphological consequences of water uptake, showing the decrease in the total amount and the fractal dimension of micro-voids by scanning electron microscopy and image processing. The other shows, by mechanical spectrometry, the effect of water on physical or chemical bonds. In both cases, the “low profile agent” in SMC plays an important role. The molecular mobility was taken as a sensor parameter for the structural changes at the molecular scale, highlighting and quantifying the first steps of the aging. The loss factor level increases, and the activation energies are modified, even for the first aging days. The analysis shows recovery for the material near the relaxation peak of the low profile agent, since the curve recovers its initial shape. 相似文献
4.
Blends of unsaturated polyester resin and polyvinylacetate (PVAc) were cured between two glass slides. In this case, the low-profile
effect arises by fissuring with a fractal geometry. This paper shows how the fractal dimension of the fissures depends on
the PVAc amount and on the cure temperature. These results are discussed with the present knowledge about the polyester network
morphology in two phases more or less co-continuous. 相似文献
5.
Merle Schmahl Cecilia Müller Reinhard Meinke Erika G. Alves Alcantara Ude D. Hangen Claudia Fleck 《Advanced Engineering Materials》2023,25(10):2201676
Cyclic nanoindentation allows characterizing the influence of single phases and their interactions on fatigue mechanisms. Herein, a method for high cycle fatigue testing by nanoindentation is presented. By combining high- and low-frequency indentation modes, high cycle numbers are achieved while obtaining sufficient data points to reconstruct force–displacement hysteresis loops. A challenge is the stochastic course of thermal drift which is addressed by measuring drift rate in regular low-force holding segments. Drift rates are used to correct the displacement values, yielding reproducible cyclic deformation data as it is shown for two very different materials, a ductile metal and a brittle ceramic. 相似文献
6.
Challita Stphanie Korte Fabian Erbel Johannes Zalila Faiez Grabowski Jens Merle Philippe 《Software and Systems Modeling》2021,20(5):1609-1631
Software and Systems Modeling - With the advent of cloud computing, different cloud providers with heterogeneous cloud services (compute, storage, network, applications, etc.) and their related... 相似文献
7.
8.
Syed Jafar Mehdi Hector Rosas-Hernandez Elvis Cuevas Susan M. Lantz Steven W. Barger Sumit Sarkar Merle G. Paule Syed F. Ali Syed Z. Imam 《International journal of molecular sciences》2016,17(9)
Currently, the lack of new drug candidates for the treatment of major neurological disorders such as Parkinson’s disease has intensified the search for drugs that can be repurposed or repositioned for such treatment. Typically, the search focuses on drugs that have been approved and are used clinically for other indications. Kinase inhibitors represent a family of popular molecules for the treatment and prevention of various cancers, and have emerged as strong candidates for such repurposing because numerous serine/threonine and tyrosine kinases have been implicated in the pathobiology of Parkinson’s disease. This review focuses on various kinase-dependent pathways associated with the expression of Parkinson’s disease pathology, and evaluates how inhibitors of these pathways might play a major role as effective therapeutic molecules. 相似文献
9.
UV-A (near-UV), UV-C (short-UV) and visible-light assisted Fenton-like treatment of Bisphenol A (BPA) was investigated in pure water and raw freshwater samples spiked with BPA. Treatment performances were evaluated in terms of BPA degradation, dissolved organic carbon (DOC) removal and H2O2 consumption rates. Complete BPA degradation accompanied with significant DOC removal was achieved for all studied processes. Increasing the initial solution pH only exhibited a negative effect on treatment efficiencies when bicarbonate alkalinity was used for pH adjustment, whereas the raw freshwater matrix and irradiation type also influenced oxidation rates appreciably. Acute toxicity analysis employing Vibrio fischeri revealed that the inhibitory effect of BPA decreased significantly during the course of Photo-Fenton-like treatment. Several transformation products could be identified via HPLC and GC–MS analyses including hydroxylated phenolic compounds (hydroquinone; 2-methoxy, 1-4-benzenediol; 4-isopropenylphenol; 4′-hydroxy-acetophenone; 1-(4-cyclohexylphenyl) ethanone; 4-isopropylenecatechol; 4-4′-dihydroxybenzophenone; 4-ethyl,1,3-benzenediol), as well as the ring opening products hexanoic acid methyl ester, fumaric, succinic and oxalic acids. A reaction pathway featuring hydroxylation, dimerization and ring opening steps is proposed. 相似文献
10.
Hoft Richard Khuwatsamrit Thakoengdet Foldes Andrew Morozowich Merle 《Industry Applications, IEEE Transactions on》1983,(5):717-724
The design and performance of a people mover?a 30- kVA 400-Hz transistor inverter which furnishes all loads, except propulsion power, on a small advanced urban transit vehicle?is described in this first installment of a two part sequence of papers. With a nominal 750-V dc input, the inverter supplies 30 kVA at 0.8-lagging power factor, 200-V line-to-line root mean square (rms), and three- phase 400-Hz output. The design and performance of the power circuit is described in Part I, and the design and performance of the control is covered in Part II. 相似文献