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1.
Wireless Personal Communications - Data security is currently become a serious concern in wireless communication system for both the users and providers. Without a secure medium, the data...  相似文献   
2.
Context and objective: The aim of this study was to develop, characterize and evaluate a mucoadhesive caplet resulting from a polymeric blend (polymeric caplet) for intravaginal anti-HIV-1 delivery.

Materials and methods: Poly(lactic-co-glycolic) acid, ethylcellulose, poly(vinylalcohol), polyacrylic acid and modified polyamide 6, 10 polymers were blended and compressed to a caplet-shaped device, with and without two model drugs 3′-azido-3′-deoxythymidine (AZT) and polystyrene sulfonate (PSS). Thermal analysis, infrared spectroscopy and microscopic analysis were carried out on the caplets employing temperature-modulated DSC (TMDSC), Fourier transform infra-red (FTIR) spectrometer and scanning electron microscope, respectively. In vitro and in vivo drug release analyses as well as the histopathological toxicity studies were carried out on the drug-loaded caplets. Furthermore, molecular mechanics (MM) simulations were carried out on the drug-loaded caplets to corroborate the experimental findings.

Results and discussion: There was a big deviation between the Tg of the polymeric caplet from the Tg's of the constituent polymers indicating a strong interaction between constituent polymers. FTIR spectroscopy confirmed the presence of specific ionic and non-ionic interactions within the caplet. A controlled near zero-order drug release was obtained for AZT (20 d) and PSS (28 d). In vivo results, i.e. the drug concentration in plasma ranged between 0.012–0.332?mg/mL and 0.009–0.256?mg/mL for AZT and PSS over 1–28 d.

Conclusion: The obtained results, which were corroborated by MM simulations, attested that the developed system has the potential for effective delivery of anti-HIV-agents.  相似文献   
3.
The introduction of high spatial and spectral resolution sensors on-board remote-sensing spacecraft has increased, by orders of magnitude, the data rates which need to be sustained on the down-link or cross-link transmission channels. Since these channels are severely limited in capacity, the need arises to perform on-board compression to reduce the volume of data which would need to be down-linked. This paper discusses the development and refinement of a low complexity lossy spectral/spatial compression method which provides high compression ratios at low levels of distortion. The developed techniques uses pixels in adjacent bands to predict the intensity of pixels in the band being compressed via a simple linear prediction model. This prediction method when combined with a low-distortion discrete cosine transform (DCT) block coding method yields performance comparable to block-adaptive Karhunen-Loeve Transform (KLT)-DCT methods without incurring the complexity penalty of the KLT. The methods' performance suffers under misregistration. A fractional-pixel interpolation enhancement to the basic technique significantly improves the performance in the case of misregistered bands  相似文献   
4.
There have been many successful e‐businesses as well as many failed e‐businesses. The methods and practices that were evident in the development of both surviving e‐businesses and failed ones have much to teach us. Why did some e‐businesses fail while others survived? At present few guidelines exist to assist e‐business owners and managers wanting to succeed in their Internet‐based ventures. This study empirically investigated factors that may lead to e‐business success or failure; these were categorized as management, market, and financial factors. The results of a survey were combined with one‐on‐one interviews of venture capitalists who funded successful and failed e‐businesses. The results indicate that certain factors deemed applicable to an e‐business may have contributed to the firm’s eventual success or failure.  相似文献   
5.
To convey the dynamic information related to traffic conditions in various parts of a city, we propose an environment utilizing the technology of smart phones to provide information anywhere and anytime. Called ";The Interactive Traffic Beat Project,"; it uses a Web-based service to deliver this information to people through their cell phones at the right time so that valuable time can be saved and the chaos on the roads can be managed.  相似文献   
6.
The castings produced by the evaporative pattern casting (EPC) process have blow holes. The blow holes in EPC castings are because of the non-escape of the gas produced as a result of burning of polystyrene pattern in the sand mold. To overcome the problem of blow holes, the EPC process is combined with the vacuum (V)- process. The vacuum applied to EPC mold draws the decomposed gases and improves the casting quality produced by the EPC process. The developed hybrid process has been termed as the vacuum assisted evaporative pattern casting (VAEPC) process. The objective of this paper to investigates the effect of process parameters, i.e, degree of vacuum, pouring temperature, grainfineness number, amplitude of vibration and time of vibration on the impact strength of Al-7% Si alloy castings in VAEPC process. In order to evaluate the effect of selected process parameters, the response surface methodology (RSM) is used to formulate a mathematical model which correlates the independent process parameters with the desired impact strength. The central composite rotatable design has been used to conduct the experiments. The results indicate that the impact strength decreases with increases in the grainfineness number and pouring temperature. Whereas, it has an inverse relationship with amplitude of vibration, time of vibration and degree of vacuum. The best value of impact strength (2.34 N/mm2) has been obtained at 400 mm Hg degree of vacuum imposed, 650°C as pouring temperature, 60 as sand grainfineness number, 460 μm as amplitude of vibration, and 70 s as time of vibration.  相似文献   
7.
8.
There is a need for developing low cost, easily and abundantly available, yet efficient, adsorbents for the removal of phosphates during the tertiary treatment of wastewaters. The tamarind nut shell activated carbon (TNSAC) prepared on a laboratory scale has been used to evaluate its performance for phosphate adsorption. This paper describes the laboratory production of this adsorbent material in its various forms, and discusses the effects of the TNSAC process variables (the unrinsed and rinsed forms of the TNSAC and the impregnation ratio) on its performance in adsorbing phosphate. The material has been shown to be a good alternative adsorbent. As much as 95% phosphate removal by the unrinsed TNSAC is possible in about 30 min under the test conditions. The phosphate adsorbing capacity is about two times higher for the unrinsed TNSAC in comparison to the rinsed TNSAC. The adsorption rates, however, transit to extremely low rates towards the end when equilibrium conditions could be attained in about 2 h contact time. The phosphate removal mechanics are adsorption and precipitation/ion exchange when unrinsed TNSAC is used, and adsorption alone for the rinsed TNSAC. The maximum phosphate removal is found to take place at an impregnation ratio of 1.0 for both forms of the TNSAC.  相似文献   
9.
In the present work Taguchi's approach has been applied to the V-process castings of Al-11 per cent Si alloy to acertain the most influential control factors which will provide better and consistent surface finish to the castings regardless of the noise factors present. The control factors of the V-process that may affect the quality of the castings are the molding sand, vibration frequency, vibrating time, degree of vacuum imposed, and pouring temperature. In order to understand how these factors affect the surface roughness of the V-process castings, response surface methodology has been applied, and to obtain the optimal setting of the control factors Taguchi's method has been used. It is found that the pouring temperature has a significant effect on the surface roughness of Al-11 per cent Si alloy castings made by a V-process. Thus the pouring temperature must be kept at the lower level. All other factors are insignificant. Therefore, any setting of the insignificant factors/variables that give the minimum cost can be used.  相似文献   
10.
Understanding how the structure of the unit-cell affects the cryogenic performance of a Si power Metal Oxide Semiconductor Field Effect Transistor (MOSFET) is an important step toward optimizing of the device for cryogenic operations. In this paper, numerical simulations of the Si power Double Diffused MOSFET’ (DMOS) are performed at room temperature and cryogenic temperatures. Physically based models for temperature dependent silicon properties are employed in the simulations. The performances of power DMOS’ with various unit-cell structures are compared at both room temperature and low temperatures. The effect of the cell structure on the on-resistance and breakdown voltage of the device are analyzed. The simulation results suggest that the device optimized for room temperature operation can be further optimized at cryogenic temperatures.  相似文献   
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