DNA Methylation Signatures of Bone Metabolism in Osteoporosis and Osteoarthritis Aging-Related Diseases: An Updated Review

DNA methylation is one of the most studied epigenetic mechanisms that play a pivotal role in regulating gene expression. The epigenetic component is strongly involved in aging-bone diseases, such as osteoporosis and osteoarthritis. Both are complex multi-factorial late-onset disorders that represent a globally widespread health problem, highlighting a crucial point of investigations in many scientific studies. In recent years, new findings on the role of DNA methylation in the pathogenesis of aging-bone diseases have emerged. The aim of this systematic review is to update knowledge in the field of DNA methylation associated with osteoporosis and osteoarthritis, focusing on the specific tissues involved in both pathological conditions.     

Influence of ZrB2 hard ceramic reinforcement on mechanical and wear properties of aluminum

In this work, the effect of ZrB₂ (0, 5, 10 and 20?vol%) ceramic reinforcement on densification, structure, and properties of mechanically alloyed Al was investigated. The milling of Al-ZrB₂ powder compositions resulted in formation of agglomerates with varied size. In particular, the size of agglomerates was reduced considerably with increased addition of ZrB₂ to Al. Interestingly, the densification of hot pressed Al increased from 96.06% to 99.22% with ZrB₂ addition. The reduction of agglomerates size was attributed to the enhanced densification of Al-ZrB₂ composites. Pure Al showed relatively low hardness (0.94?GPa) and it was improved to 1.78?GPa with the addition of 20?vol% ZrB₂. The mechanical properties have significantly been improved for Al-ZrB₂ composites. Especially Al - 20?vol% ZrB₂ possessed a very high yield strength (529?MPa), compressive strength (630?MPa) and compressive strain of 19.25%. Realization of such a good combination of mechanical properties is the highest ever reported for Al composites so far in the literature. The coefficient of friction (COF) of Al-ZrB₂ varied narrowly between 0.33 and 0.40 after dry sliding wear against steel disc. The wear rate of Al-ZrB₂ composites was within mild wear regime and varied between 98.88?×?10^?6 and 34.66?×?10^?6 mm³/Nm. Among all the compositions, Al - 20?vol% ZrB₂ composite exhibited the lowest wear rate and high wear rate was noted for pure Al. Mild abrasion, tribo-oxidation, third body wear (wear debris) and delamination were the major material removal mechanisms for Al-ZrB₂ composites. Overall the hardness, strength and wear resistance of Al - 20?vol% ZrB₂ composite was improved by 84.3%, 84.3% and 64.2%, respectively when compared to pure Al.     

Privacy-preserving iris authentication using fully homomorphic encryption

Multimedia Tools and Applications - Rapid advancement in technology has led to the use of biometric authentication in every field. In particular, from the past few years, iris recognition systems...     

利用高性能模拟器件简化便携式医疗设备设计

目前,医疗电器OEM厂商正在开发技术含量更高的、用于治疗和监控常见疾病的个人保健设备。这些产品价格合理,极大提高了医疗保健质量。MCU在家用血压计、肺活量计、脉搏血氧计及心率监测器等便携式医疗设备中起着重要作用。大多数此类产品中的实际生理信号是模拟信号,在测量、监控或显示前需要进行放大、过滤等处理。     

Application of Differential Evolution for Irrigation Planning: An Indian Case Study

The present paper demonstrates the applicability of population based search optimization method, namely, Differential Evolution (DE) to a case study of Mahi Bajaj Sagar Project (MBSP), India. Ten different strategies of DE are employed to assess the ability of DE for solving higher dimensional problems as an alternative methodology for irrigation planning. The parameters considered in DE are population size, crossover constant and weighting factor. Linear Programming (LP) is utilized as a comparative approach to assess the ability of DE. Comparison of results of LP and the 10 DE strategies for the given parameters indicated that both the results are comparable even for high dimensional problems. Extensive sensitivity analysis studies, performed for 3,600 combinations of above parameters for the 10 DE strategies suggested that DE/rand-to-best/1/bin strategy is the best strategy giving maximum benefits taking minimum CPU time. It is concluded that DE can be utilized for efficient planning of any irrigation system with suitable modifications.     

Post-buckling behaviour of moderately thick cylindrically orthotropic annular plates

A finite element formulation including the effects of shear deformation and cylindrically orthotropic material properties is described for studying the post-buckling behaviour of annular plates. Numerical results for the buckling load parameter and ratios of nonlinear load parameter to buckling load parameter for various values of orthotropic properties, thicknesses and radii ratios of the plates are presented.