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排序方式: 共有234条查询结果,搜索用时 46 毫秒
1.
N Usui S Kamata S Ishikawa T Sawai H Okuyama K Imura A Okada 《Canadian Metallurgical Quarterly》1996,31(2):258-262
Bone marrow examination revealed a lipid-laden histiocytosis in seven patients undergoing long-term total parenteral nutrition necessitated by extensive short-bowel surgical resection. Clinical abnormalities occurred during this treatment which required bone marrow examination. These included hepatosplenomegaly and peripheral blood cytopenia; the median time to the detection of these abnormalities was 64 months. The most striking change within the bone marrow was the presence of many pigment-laden histiocytes which had the typical morphology of sea-blue histiocytes seen in the so-called idiopathic sea-blue histiocyte syndrome. The occurrence of sea-blue histiocytosis in the bone marrow in association with long-term parenteral nutrition for short-bowel syndrome has not, to our knowledge, been reported previously and should now be considered in the differential diagnosis of bone marrow sea-blue histiocytosis. 相似文献
2.
M Suda K Tanaka K Natsui T Usui I Tanaka M Fukushima C Shigeno J Konishi S Narumiya A Ichikawa N Nakao 《Canadian Metallurgical Quarterly》1996,137(5):1698-1705
PGE2 is one of the key molecules in the osteoblast. It is the major prostanoid in the bone, and its production is under the control of both systemic and local factors. PGE2 has been reported to have multiple actions in the osteoblast, such as growth promotion and cell differentiation. To better understand the action of PGE2 in the osteoblast, we determined the PGE receptor subtypes in MC3T3-E1, an osteoblastic cell line derived from the normal mouse calvaria. Northern blot analysis revealed that EP1 and EP4 subtypes are expressed in MC3T3-E1. In contrast, EP3 subtype was not detected by either Northern blot analysis or RT-PCR. The contribution of each subtype was evaluated by studying the effects of subtype-specific analogs on osteoblastic function at confluency and 5 days after confluency. An EP1 agonist, 17-phenyl-omega-trinor PGE2, increased DNA synthesis and decreased alkaline phosphatase activity. 11-Deoxy-PGE1, and EP2 and EP4 agonist, decreased DNA synthesis and increased alkaline phosphatase activity at both stages. Butaprost, an EP2-selective agonist, showed effects similar to those of 11-deoxy-PGE1 only at confluency. Another and more differentiated osteoblastic marker, osteocalcin production, was detectable and was stimulated by 11-deoxy-PGE1 only 5 days after confluency. The exposure of these cells to EP1 agonist changed the cell shape to a more fibroblastic appearance. These results indicate that EP1, EP4, and probably EP2 are present in MC3T3-E1 cells; EP1 promotes cell growth, and EP2 and EP4 mediate differentiation of the osteoblast. Furthermore, the decreased response to EP2-specific agonist 5 days after confluency suggests that the expression of PGE receptor subtype is dependent on the stage of osteoblastic differentiation. This is the first report to determine PGE receptor subtypes in the bone. 相似文献
3.
Kawahito S. Ueda S. Ishida M. Nakamura T. Usui S. Nagaoka S. 《IEEE transactions on bio-medical engineering》1994,41(4):400-406
A CMOS integrated circuit for a noninvasive biological-signal telemetry system specified for use in medical and physiological studies of the influence of weightlessness in space is presented. The system can monitor multichannel (4 channels maximum) biological signals from multiple subjects (4 subjects maximum) in real time by using time multiplexing. A key technique so-called synchronized multiple-subject telemetry, to achieve multiple-subject telemetry has been proposed. This technique utilizes bidirectional optical transmissions with direct and scattered infrared lights between an observer and each of the subjects. An experimental CMOS IC to give a small light-weight low-power, and smart telemetry instrument for use on animals has been developed. This IC is for evaluating circuit blocks of the implantable monolithic telemetry instrument. The major circuit blocks include CMOS digital circuits for synchronization, subject selection and time multiplexing, analog circuits for pulse interval modulation, and other blocks such as a CMOS optical pulse receiver and an LED driver. A preliminary experimental multichannel telemetry from two subjects has been performed with the implemented IC chips, and the principal operation of the multiple-subject optical biotelemetry has been demonstrated 相似文献
4.
Y Tokura K Yamanaka H Wakita S Kurokawa D Horiguchi A Usui S Sayama M Takigawa 《Canadian Metallurgical Quarterly》1994,130(8):1036-1041
BACKGROUND: Halo congenital nevus is a condition in which halo formation is associated with congenital nevocellular nevi. Although several theories have been proposed, the immunologic mechanisms of halo formation and concomitant nevus regression still remain unclear. We presented immunologic findings in a case of halo congenital nevus with unique histologic location of inflammatory cells. OBSERVATIONS: Histologically, the present case of halo congenital nevus undergoing spontaneous regression showed a marked inflammatory infiltrate with remnants of original nevus cell nests. In the infiltrating T cells, CD8+ cells outnumbered CD4+ cells and the infiltrate of natural killer cells was not substantial. Direct and indirect immunofluorescence studies demonstrated the presence of IgM antibodies against nevus cells as well as melanoma cells and cultured melanocytes in the patient's serum. CONCLUSIONS: Our findings suggest that both T-cell-mediated immunity and IgM antibodies may be involved in the regression of halo congenital nevus. However, it is important to point out that our results may simply be epiphenomena and not directly responsible for the destruction of nevus cells. 相似文献
5.
C Nishiyama M Fukada Y Usui N Iwamoto T Yuuki Y Okumura H Okudaira 《Canadian Metallurgical Quarterly》1995,32(14-15):1021-1029
Der f 2 is a major mite allergen composed of 129 amino acid residues. To determine the major epitopes on Der f 2 recognized by human IgE antibodies, artificial mutations were introduced to Der f 2 protein. The IgE-binding activity of Der f 2 was significantly decreased by deletion of 10 amino acids at the N-terminus or nine amino acids at the C-terminus. Site-directed mutagenesis with a single amino acid replacement by Ala or Leu in both N- and C-terminal regions as well as a central portion was performed to generate 42 single-site mutations. Amino acid replacement around a disulfide bond of Cys8-Cys119 caused a marked decrease in IgE-binding activity. Furthermore, a distinct decrease in IgE-binding was also caused by Ala-substitution close to a disulfide bond of Cys73-Cys78 and by mutations of a few charged residues. From these results, it was concluded that the two disulfide-forming regions of Der f 2 and several charged residues are important for forming major epitope structures recognized by human IgE antibodies. 相似文献
6.
Takayuki Usui Reimer Behrends Jacob Evans Yannis Smaragdakis 《Journal of Parallel and Distributed Computing》2010
Transactional memory is being advanced as an alternative to traditional lock-based synchronization for concurrent programming. Transactional memory simplifies the programming model and maximizes concurrency. At the same time, transactions can suffer from interference that causes them to often abort, from heavy overheads for memory accesses, and from expressiveness limitations (e.g., for I/O operations). In this paper we propose an adaptive locking technique that dynamically observes whether a critical section would be best executed transactionally or while holding a mutex lock. The critical new elements of our approach include the adaptivity logic and cost–benefit analysis, a low-overhead implementation of statistics collection and adaptive locking in a full C compiler, and an exposition of the effects on the programming model. In experiments with both micro and macrobenchmarks we found adaptive locks to consistently match or outperform the better of the two component mechanisms (mutexes or transactions). Compared to either mechanism alone, adaptive locks often provide 3-to-10x speedups. Additionally, adaptive locks simplify the programming model by reducing the need for fine-grained locking: with adaptive locks, the programmer can specify coarse-grained locking annotations and often achieve fine-grained locking performance due to the transactional memory mechanisms. 相似文献
7.
This paper concentrates on the experimental investigation of the self-reinforced all-polypropylene composites. There exists an optimum processing condition to produce high quality specimens by injection–compression molding. Tensile and 3-point bending properties of the virgin PP materials were nearly unaffected by the introduction of reinforcing knit layer(s) due to very low fibre content of the knitted fabrics used. 3-point bending properties were also unaffected by the surface of indentation-flexure. The applied impact energy was maintained at 5 J for the homo-PP and 27 J for the block-PP materials, respectively, to cause penetration during drop-weight impact tests. It is interestingly noteworthy that the self-reinforced homo-PP composites exhibited superior energy absorption capability when compared with the virgin matrix materials. The corresponding plate bending performances of the self-reinforced homo-PP composites also revealed consistent improvement as compared to their virgin counterparts. On the other hand, although virgin block-PP material exhibited better impact performances than its composite reinforced by the homo-PP knitted fabric, a notably small increase in the reinforcement fibre content revealed considerable improvement in the impact properties comparable to those of the virgin block-PP matrix materials. These self-reinforced homo-PP/block-PP materials have clearly indicated that they have the potential to out-perform the block-PP materials via modification and/or manipulation of the reinforcement knit structural/geometrical parameters and the content of reinforcement fibres. Both static and dynamic impact properties are likely to be affected by the local area properties of the tested face under indentation, and thereby contributing to the improved performances of the composite specimens with the knit face under the impact. 相似文献
8.
9.
AgGaTe2 and AgAlTe2 layers were grown on a-plane sapphire substrates by closed-space sublimation. These compounds replace Cd in CdTe with group I and III elements, and are, hence, expected to be ideal novel candidate materials for solar cells. The grown layers were confirmed to be stoichiometric AgGaTe2 and AgAlTe2 by x-ray diffraction (XRD). The AgAlTe2 layers had strong preference for the (112) orientation. The XRD spectrum of the AgGaTe2 layer was different from that of the AgAlTe2 layer, and strong peaks were observed for (103) and (110) diffraction. The variation in orientations of the grown layers was analyzed in detail by use of XRD pole figures, which revealed that the AgGaTe2 layers had an epitaxial relationship with the a-plane sapphire substrates. 相似文献
10.
Emi Hasegawa Hiroshi Suzuki Kananko Kameyama Yoshiyuki Komoda Hiromoto Usui 《Advanced Powder Technology》2009,20(2):139-144
In this paper, a model estimating the time-dependent distribution of cluster size consisting of fine particles in Newtonian molten polymer was proposed. The present model for agglomerative suspension was developed based on Usui’s thixotropy model, derived by taking the balance between shear breakup, shear coagulation and Brownian coagulation processes. The analysis was applied to the experimental results for silica/(ethylene methyl-meta acrylate copolymer) suspensions. The time variations of cluster size distributions, of viscosities and of the mean numbers of particles in a cluster were calculated and the results were compared with experimental results for the cases of shear rates from 0.2 to 10 s?1 when the solid volume fraction was set at 0.15. From the results, it was found that the present model can estimated the steady state values of the slurry viscosity and the mean particle numbers in a cluster as well as Usui’s original model. However, the model could not sufficiently express the time variation of rheological characteristics due to the over-estimation of the contribution of shear rate when the cluster size is small. 相似文献