Combating Biofilm Associated Infection In Vivo: Integration of Quorum Sensing Inhibition and Photodynamic Treatment based on Multidrug Delivered Hollow Carbon Nitride Sphere

Recently, quorum sensing (QS) inhibitors (QSIs) have been combined with antibiotics to enhance antibiofilm efficacy in vitro and in vivo. However, targeting QS signals alone is not enough to prevent bacterial infections. Drug resistance and recurrence of biofilms makes it difficult to eradicate. Herein, photodynamic therapy (PDT) is selected to unite QSIs and antibiotics. A synergistically antibiofilm system, which combines QSIs, antibiotics, and PDT based on hollow carbon nitride spheres (HCNSs) is envisaged. First, HCNS provides the multidrug delivering ability, enabling QSIs and antibiotics to be released in sequence. Subsequently, multistage releases sensitize bacteria effectively, potentiating the chemotherapeutic effects of the antibiotics. Finally, the integration of QSIs and PDT not only minimizes the possibility of drug resistance, but also overcomes the problem of limited mass and extension of PDT. Even after 48 h of incubation, the bacterial biofilm is obviously inhibited. And its biofilm disperse efficiency exceeds 48% (compared with QSI‐potentiated chemotherapy group) and 40% (compared with PDT group). Besides, the inhibition of the QS system influences phenotypes related to virulence factor production and surface hydrophobicity, which weaken biofilm invasion and formation. Eventually, this system is applied to disperse bacterial biofilm in vivo. Overall, PDT and QS modulation are devoted to eradicate drug resistance and recurrence of the biofilm.     

斜拉索-磁流变阻尼器系统半主动控制的神经网络法

磁流变阻尼器具有良好的可变阻尼特性，能用于结构的半主动控制。针对斜拉桥拉索-磁流变阻尼器系统，本文提出了利用神经控制器进行半主动控制的神经网络法，该神经控制器根据过去时刻的加速度响应和控制信号预测下一时间步的控制信号，并给出了训练方法及开展了数值仿真研究。仿真结果显示，采用神经网络半主动控制能取得很好的减振效果，证明该方法是可行的。     

减压渣油与FCC油浆共炭化的化学组成变化

考察了齐鲁石化胜利炼油厂催化油浆（FCC）和胜利减压渣油（VR）在490℃，0.8MPa下不同混合比的原料和不同反应时间的中间产物的HS、TS、PS、P及其1h中间产物的HS和TS的^1H-NMR。数据结果反映了体系的反应速度。掺入FCC油浆抑制了VR的反应活性，降低了体系的反应速度，增加了基质的溶解度；1h中间产物的组成结构更接近于原料及反应体系的反应性和基质的溶解度；1h中间产物的芳香度越高，取代基越少，侧链越短，基质对VR中的活性反应组分在炭化早期生成的高度缩合物质的溶解度越大。     

高分子纳米LB膜的制备及其光刻性能研究

合成并表征了N-十六烷基丙烯酰胺（HDA）和对叔丁基苯酚甲基丙烯酸酯（BPhMA）的共聚物p（HDA-BPhMA）s。当HDA含量较高时，共聚物可在气，液界面上形成稳定，排列紧密的单分子薄膜，并可以Y型膜的方式沉积在各种固体基片上，形成多层均匀的Langrnuir-Blodgett（LB）膜。这种LB膜被成功地应用于光刻，获得了分辨率为0.5μm的LB膜图形。以该图形为抗蚀层，可将图形进一步转移至金属薄膜上，得到分辨率较高的金属图形，在图形转移的过程中，这种LB膜显示出较高的抗蚀性，有望作为纳米抗蚀薄膜材料在亚微米刻蚀领域得到应用。     

温度敏感葡聚糖凝胶的合成及其细胞相容性研究

合成了N-异丙基丙烯酰胺（NIPAAm）与葡聚糖的共聚水凝胶，利用红外光谱表征了单体和凝胶结构，研究了水凝胶在去离子水和细胞培养基中的温度响应性，并对凝胶进行了细胞培养和脱附研究．结果表明，共聚凝胶具有很好的温度敏感性和细胞相容性，可以通过控制温度变化，实现对细胞的无损伤脱附．     

桥梁颤振气动导数识别的迭代法

本文提出一种利用自由振动响应通过年顿－拉夫逊迭代同时识别出桥梁全部8个颤振气动导的方法。此法具有对迭代初值要求不高，识别结果稳定的特点，并具有一定的抗噪声干扰能力。数字仿真与实物试验结果表明本文方法有效，可行。     

机器人骨骼-肌肉系统工程模拟的动态分析

用振动学理论对仿人机器人骨骼-肌肉系统工程模型进行了分析，并提出了一种控制振动的方法，提高仿人机器人运动精度和缩短达到稳定的时间，同时阐述了这种方法的可行性。     

供应链环境下的性能评价系统研究

在竞争全球化的趋势下，供应链管理越来越受到企业重视，供应链性能评价系统(supply Chain Performance Mea-surement System,SCPMS)是供应链管理的关键组成部分，然而企业却不愿意或没有能力建立有效的性能评价系统。总结了供应链性能评价的定义、发展过程及难点，在此基础上提供了一套供应链性能评价的方法，为企业快速建立集成供应链性能评价系统提供借鉴。     

Preparation of a pitch-based activated carbon with a high specific surface area

Pitch based activated carbons (PAC) with a high specific surface area were produced by a direct chemical activation route in which oxidative stabilized pitch derived from ethylene tar oil was reacted with potassium hydroxide under various activation conditions. It was found that PACs with a surface area of around 2600–3600 m² g^-1 could be obtained under suitable activation conditions. N₂ adsorption (at 77 K) and X-ray photoelectron spectroscopy experiments showed that the PAC has a uniformly developed micropore structure and a narrow pore size distribution (radius 0.8–1.6 nm). Abundant oxygen-containing functional groups (such as C–OH, C–O–C, C=O, COOR etc.) were found to exist on its surface. Compared with a commercially available activated carbon (AC) and also a pitch based activated carbon fibre, PAC has a quicker adsorption–desorption velocity and a larger adsorptive capacity to benzene due to its higher surface area. Clear surface differences between PAC and AC were observed by transmission electron microscopy. This revised version was published online in November 2006 with corrections to the Cover Date.     

一种基于DBF的双基地雷达系统的性能分析与实验研究

讨论了一种基于数字波束形成的脉冲追赶式双基地雷达系统的构成和基本工作原理．对该双基地雷达的性能进行了理论分析，并通过实验结果进行了验证。