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排序方式: 共有206条查询结果,搜索用时 15 毫秒
1.
Davide De Biase Giuseppe Piegari Francesco Prisco Ilaria Cimmino Ilaria dAquino Valeria Baldassarre Francesco Oriente Serenella Papparella Orlando Paciello 《International journal of molecular sciences》2021,22(7)
Sarcopenia is defined as the age-related loss of skeletal muscle mass, quality, and strength. The pathophysiological mechanisms underlying sarcopenia are still not completely understood. The aim of this work was to evaluate, for the first time, the expression of NLRP3 inflammasome in bovine skeletal muscle in order to investigate the hypothesis that inflammasome activation may trigger and sustain a pro-inflammatory environment leading to sarcopenia. Samples of skeletal muscle were collected from 60 cattle belonging to three age-based groups. Morphologic, immunohistochemical and molecular analysis were performed to assess the presence of age-related pathologic changes and chronic inflammation, the expression of NLRP3 inflammasome and to determine the levels of interleukin-1β, interleukin-18 and tumor necrosis factor alpha in muscle tissue. Our results revealed the presence of morphologic sarcopenia hallmark, chronic lymphocytic inflammation and a type II fibers-selective NLRP3 expression associated to a significant decreased number of immunolabeled-fibers in aged animals. Moreover, we found a statistically significant age-related increase of pro-inflammatory cytokines such as interleukin-1β and interleukin-18 suggesting the activation of NLRP3 inflammasome. Taken together, our data suggest that NLRP3 inflammasome components may be normally expressed in skeletal muscle, but its priming and activation during aging may contribute to enhance a pro-inflammatory environment altering normal muscular anabolism and metabolism. 相似文献
2.
This article proposes a model of the ways in which dyadic interactions between employees who occupy 1 of 4 archetypal social roles in organizations can lead to either episodic or institutionalized patterns of victimization. The model shows how the occurrence of victimization involving these 4 role types is influenced by organizational variables such as power differences, culture, and access to social capital. The model integrates behavioral and social structural antecedents of victimization to develop a relational perspective on the dynamics of harmful behavior in the workplace. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
3.
This paper investigates the effect of chelating agents on the bioavailability of Fe and Cu during anaerobic digestion. The results on metal speciation and methane production in anaerobic serum bottles showed that biomass was able to grow in the presence of citrate 1?mM and nitrilotriacetic acid (NTA) 1?mM, suggesting that the binding sites at the cell surface competed efficiently for the metals with the chelating agents added. The presence of free ethylenediaminetetraacetic acid 1?mM inhibited methanogenesis, and this seemed to be related to a loss in metal uptake capacity. Although the addition of soluble microbial products (SMP) did not change metal distribution in anaerobic systems, it caused an increase in the rate of methane production, and it is believed that direct uptake of Cu-SMP complexes was responsible for this increase. The best protection against Cu toxicity occurred when stoichiometric amounts of NTA, which should complex and solubilize most of the Cu, was added, and it is likely that NTA prevented lethal concentrations of Cu from being adsorbed onto the cell and hence internalized. 相似文献
4.
Prior theory and research suggests a positive relation between perceived victimization and overt anger. The authors proposed and tested a theoretical extension of this link by investigating possible moderating effects of individual and contextual variables. A sample of 158 employees of a municipality was used to test hypotheses that the relationship between perceived victimization and overt anger is moderated by hostile attributional style and perceptions of organizational norms. The results showed that the relation between perceptions of direct victimization and overt anger was stronger when the employee had a more rather than less hostile attributional style and when the employee perceived the organizational norms as more rather than less oppositional. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
5.
Andrea Cerciello Pasquale Del Gaudio Marco Cantarini Rita P. Aquino 《Drug development and industrial pharmacy》2016,42(12):2063-2069
Context: Ketoprofen lysinate (KL) is one of the most widely used non-steroidal anti-inflammatory drugs in the symptomatic treatment of some chronic inflammatory diseases. Compared to ketoprofen, KL shows better pharmacokinetics and tolerability. However, due to its short half-life of 1–2?h, a multiple dose regimen is required for oral administration. Thus, the present work deals with its encapsulation in a hydrogel-based system by prilling in order to prolong its activity.Objective: In this paper, we propose alginate and pectin as carriers and release tailoring agent for the development of hydrogel-based beads for KL retarded and sustained release.Materials and methods: Beads were produced by a Nisco Encapsulator® using alginate or pectin. Operative variables were optimized to produce beads with desired morphology and size. Solid state properties were analyzed by SEM and DSC. Drug release performance was studied by Pharmacopeia pH-change assay to simulate gastrointestinal environment.Results and discussion: Prilling technique was successfully used to encapsulate high soluble drugs as KL in polysaccharides-based hydrogels. Pectin proved to be a proper polymer able to encapsulate ketoprofen lysine salt. Formulation (F8) showed good morphological properties and size, high drug content (15.6%) and encapsulation efficiency (93.5%) and promising drug release profiles. Hosting F8 in an acid-resistant capsule (DR®caps) a delivery platform has been developed to control KL release in a delayed (90?min lag time) and prolonged way (270?min complete release).Conclusion: The platform may be proposed as potentially useful in the oral administration of NSAIDs in chronic inflammatory diseases affected by circadian rhythm. 相似文献
6.
da Silva Edson Santos de Mello Prado Renato Soares Anelisa de Aquino Vidal Lacerda de Almeida Hilario Junior dos Santos Durvalina Maria M. 《SILICON》2021,13(3):813-818
Silicon - Corn plants are highly demanding of nitrogen and the application of silicon has been studied because it minimizes stress from different natures, and for the better utilization of some... 相似文献
7.
James E. Warner Manuel I. Diaz Wilkins Aquino Marc Bonnet 《Computational Mechanics》2014,54(3):645-659
This work focuses on the identification of heterogeneous linear elastic moduli in the context of frequency-domain, coupled acoustic-structure interaction (ASI), using either solid displacement or fluid pressure measurement data. The approach postulates the inverse problem as an optimization problem where the solution is obtained by minimizing a modified error in constitutive equation (MECE) functional. The latter measures the discrepancy in the constitutive equations that connect kinematically admissible strains and dynamically admissible stresses, while incorporating the measurement data as additional quadratic error terms. We demonstrate two strategies for selecting the MECE weighting coefficient to produce regularized solutions to the ill-posed identification problem: 1) the discrepancy principle of Morozov, and 2) an error-balance approach that selects the weight parameter as the minimizer of another functional involving the ECE and the data misfit. Numerical results demonstrate that the proposed methodology can successfully recover elastic parameters in 2D and 3D ASI systems from response measurements taken in either the solid or fluid subdomains. Furthermore, both regularization strategies are shown to produce accurate reconstructions when the measurement data is polluted with noise. The discrepancy principle is shown to produce nearly optimal solutions, while the error-balance approach, although not optimal, remains effective and does not need a priori information on the noise level. 相似文献
8.
de Aquino Silva Rogerio da Silva Luana Dutra Moisés Lima de Araujo Gustavo Medeiros 《Mobile Networks and Applications》2021,26(1):319-325
Mobile Networks and Applications - The text mining process typically involves the application of natural language processing (NLP) techniques, in order to obtain important information and extract... 相似文献
9.
Flvia Melo Cunha de Pinho Pessoa Caio Bezerra Machado Emerson Lucena da Silva Laudreísa da Costa Pantoja Rodrigo Monteiro Ribeiro Maria Elisabete Amaral de Moraes Manoel Odorico de Moraes Filho Raquel Carvalho Montenegro Andr Salim Khayat Caroline Aquino Moreira-Nunes 《International journal of molecular sciences》2022,23(7)
The increasing numbers of cancer cases worldwide and the exceedingly high mortality rates of some tumor subtypes raise the question about if the current protocols for cancer management are effective and what has been done to improve upon oncologic patients’ prognoses. The traditional chemo-immunotherapy options for cancer treatment focus on the use of cytotoxic agents that are able to overcome neoplastic clones’ survival mechanisms and induce apoptosis, as well as on the ability to capacitate the host’s immune system to hinder the continuous growth of malignant cells. The need to avert the highly toxic profiles of conventional chemo-immunotherapy and to overcome the emerging cases of tumor multidrug resistance has fueled a growing interest in the field of precision medicine and targeted molecular therapies in the last couple of decades, although relatively new alternatives in oncologic practices, the increased specificity, and the positive clinical outcomes achieved through targeted molecular therapies have already consolidated them as promising prospects for the future of cancer management. In recent years, the development and application of targeted drugs as tyrosine kinase inhibitors have enabled cancer treatment to enter the era of specificity. In addition, the combined use of targeted therapy, immunotherapy, and traditional chemotherapy has innovated the standard treatment for many malignancies, bringing new light to patients with recurrent tumors. This article comprises a series of clinical trials that, in the past 5 years, utilized kinase inhibitors (KIs) as a monotherapy or in combination with other cytotoxic agents to treat patients afflicted with solid tumors. The results, with varying degrees of efficacy, are reported. 相似文献
10.
Kseniya Khamina Andreas B. Diendorfer Susanna Skalicky Moritz Weigl Marianne Pultar Teresa L. Krammer Catharine Aquino Fournier Amy L. Schofield Carolin Otto Aaron Thomas Smith Nina Buchtele Christian Schoergenhofer Bernd Jilma Bernhard J. H. Frank Jochen G. Hofstaetter Regina Grillari Johannes Grillari Klemens Ruprecht Christopher E. Goldring Hubert Rehrauer Warren E. Glaab Matthias Hackl 《International journal of molecular sciences》2022,23(3)