Social support and immune function among spouses of cancer patients.

This study investigated whether social support was related to immune function among spouses of cancer patients. Effects of depression and negative life events were examined as potential mediators. Results showed evidence of greater immunocompetence on 2 of 3 dynamic measures: natural killer cytotoxicity and proliferation response to phytohemaglutinin among spouses who reported high levels of social support. All six components of social support assessed by the Social Provisions Scale (C. E. Cutrona and D. W. Russell, 1987) were strongly related to these indices of immune function. No evidence was found for mediation by either life events or depression. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Behavioral manifestations of social support: A microanalytic investigation.

Examined the specific interpersonal behaviors that convey support from one person to another, the types of interpersonal experiences that characterize individuals who report high vs low levels of social support, and the effectiveness of a range of helping behaviors in preventing depressive reactions to stressful events. 41 undergraduates completed a general measure of perceived social support and kept daily records of their social interactions and stressful experiences for 14 days. They also completed the Depression Adjective Check Lists each day. Results show that behaviors reflecting emotional support and informational support occurred as a specific response to stressful life events. Although esteem support was expressed with equal frequency in the presence and absence of stress, it was especially effective in preventing depressive reactions to stressful events. Ss who perceived themselves as having high levels of social support were more frequently the recipients of helping behaviors following stressful events than those low in perceived support. Perceived social support was only predictive of helping behaviors on days on which at least 1 stressful event occurred. The total number of helping behaviors received following stressful events was a significant negative predictor of level of depressive mood, although 1 helping behavior (frequency of confiding) was associated with higher levels of depression. Results are interpreted in terms of the buffering model of social support. (36 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

It's about timing and change: Pubertal transition effects on symptoms of major depression among African American youths.

Effects of early physical maturation and accelerated pubertal changes on symptoms of major depression were examined in 639 African American children. Three rival hypotheses, early timing, off-time, and stressful change, were tested using 2 waves of data (mean ages = 11 and 13 years). The pubertal effect operates differently according to children's gender and age. For girls, early maturation was consistently associated with elevated levels of depressive symptoms. For boys, early maturers manifested elevated levels of depression only at age 11, but these symptoms subsided by age 13. Boys who experienced accelerated pubertal growth over time displayed elevated symptom levels. Results support the early timing hypothesis for girls and the stressful change hypothesis for boys. Time at assessment is critical when examining boys' pubertal transition. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Perceived parental social support and academic achievement: An attachment theory perspective.

[Correction Notice: An erratum for this article was reported in Vol 66(4) of Journal of Personality and Social Psychology (see record 2008-10478-001). This article, which appeared in the Personality and Individual Differences section was accepted for publication by Guest Editor Irwin Sarason. We wish to thank Professor Sarason for his help and to apologize for our oversight in not acknowledging this contribution.] Tested the extent to which parental social support predicted college GPA among undergraduates. A sample of 418 undergraduates completed the Social Provisions Scale—Parent Form (C. E. Cutrona; see record 1990-01422-001) and measures of family conflict and achievement orientation. American College Testing (ACT) Assessment Program college entrance exam scores (American College Testing Program, 1986) and GPA were obtained from the university registrar. Parental social support, especially reassurance of worth, predicted college GPA when controlling for academic aptitude (ACT scores), family achievement orientation, and family conflict. Support from parents, but not from friends or romantic partners, significantly predicted GPA. Results are interpreted in the context of adult attachment theory. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Employment status, social support, and life satisfaction among the elderly.

Relations among employment status, social support, and life satisfaction were examined in a sample of 292 community-living elderly (aged 65–97 yrs) as part of a larger investigation of the role of stressful life experiences and social support in the health of the elderly. Results of a path analysis suggested that the number of hours worked at a paying job, lower levels of depression, and greater perceived social support were directly related to higher levels of life satisfaction. Furthermore, social support mediated the effects of volunteer positions on life satisfaction. These findings are discussed in relation to previous research on vocational issues among the elderly. Limitations of this study are mentioned, and suggestions for future research are offered. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Ratings of social support by adolescents and adult informants: Degree of correspondence and prediction of depressive symptoms.

It has been suggested that the personality of the individual influences appraisal processes that determine ratings of both social support and mental health, thus leading to an association between these variables that reflects only their shared self-report bias. To test whether ratings of social support made by someone other than the target individual would significantly predict outcomes, 115 pregnant adolescent girls and 115 adults who knew the adolescents well both completed ratings of the adolescent's social support. Results showed a moderate level of agreement between adolescent and informant support ratings. Both self-report and informant total social support ratings predicted pregnancy depression scores. Only informant social support ratings were significant predictors of postpartum depression scores. The ability of informants' ratings of social support to predict the adjustment of the adolescents to a major life stress was viewed as evidence that the commonly found link between social support and mental health reflects more than self-report biases. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Cross-situational consistency in causal attributions: Does attributional style exist?

Two studies evaluated the concept of an attributional style, as operationalized by the Attributional Style Questionnaire (ASQ). Study 1, with 1,333 undergraduates, examined the reliability and validity of the ASQ and analyzed the factor structure of the measure. Only weak evidence of a cross-situationally consistent attributional style was found. An attempt to identify Ss who tended to be very consistent in their causal attributions on the ASQ similarly did not provide strong support for the attibutional style concept. In Study 2, the relation between scores on the ASQ and causal attributions for actual negative events, as assessed by the Social Readjustment Rating Scale, were examined among 85 pregnant women. Attributional Style scores were poor predictors of actual causal attributions, and selecting highly consistent Ss did not improve the ASQ's predictive validity. Implications for the attributional style concept and an attributional analysis of depression are discussed. (46 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Objective determinants of perceived social support.

Examined objective characteristics of people's social networks as determinants of the perceived availability of social support in 50 60–88 yr olds and in 71 18–35 yr old mothers of 1-yr-olds. Number of network members and frequency of contact with network members, computed separately for kin and nonkin were examined as predictors of loneliness (as measured by the UCLA Loneliness Scale), overall social support, and the 6 components of social support proposed by R. Weiss (1974). Kin were found to be more effective providers than nonkin of some aspects of social support. Network characteristics were better predictors of perceived social support for the elderly than for the mothers, but a maximum of 30% of the variance in perceived social support was attributable to the objective network characteristics in either sample. It is recommended that future research on the determinants of perceived social support consider actual interpersonal behaviors, their contexts, and personality characteristics that affect the facilitation and interpretation of supportive behaviors. (37 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A High‐Throughput Automated Confocal Microscopy Platform for Quantitative Phenotyping of Nanoparticle Uptake and Transport in Spheroids

There is a high demand for advanced, image‐based, automated high‐content screening (HCS) approaches to facilitate phenotypic screening in 3D cell culture models. A major challenge lies in retaining the resolution of fine cellular detail but at the same time imaging multicellular structures at a large scale. In this study, a confocal microscopy‐based HCS platform in optical multiwell plates that enables the quantitative morphological profiling of populations of nonuniform spheroids obtained from HT‐29 human colorectal cancer cells is described. This platform is then utilized to demonstrate a quantitative dissection of the penetration of synthetic nanoparticles (NP) in multicellular 3D spheroids at multiple levels of scale. A pilot RNA interference‐based screening validates this methodology and identifies a subset of RAB GTPases that regulate NP trafficking in these spheroids. This technology is suitable for high‐content phenotyping in 3D cell‐based screening, providing a framework for nanomedicine drug development as applied to translational oncology.