S-N-P curves in 7075 T7351 and 2024 T3 aluminium alloys subjected to surface treatments

The S-N-P (stress, number of cycles, failure probability) curves for 2024 T3 and 7075 T7351 aluminium alloys were obtained. Previously, surface treatments of degreasing and different types of anodizing were applied to samples, evaluating the influence of these treatments on the fatigue life of the alloys. The determination of the S-N-P curves was done using Maennig's method. Rotary fatigue was used because this technique produces greater stress on the sample surfaces, the zone in which it is important to evaluate fatigue resistance. Both the transition range and the finite life range were evaluated, calculating the 1, 50 and 99% fracture probability. SEM was performed in order to characterize the fracture micromechanism. The conclusions were that Maennig's method is useful to evaluate fatigue life of these materials in a fast and efficient manner. Moreover, surface treatments produce a decrease in the fatigue life of both alloys, associating this effect with the surface damage produced on each sample during the treatment.     

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Author describes one case of septic metrothrombophlebitis and acute renal failure in pregnant woman as a result of spontaneous abortion. He discusses some clinical criteria of developing complications and proposes adequate therapeutic line of behaviour.     

Bayes estimation of the linear hazard-rate model

In life testing, the failure-time distributions are often specified by choosing an appropriate hazard-rate function. The class of life-time distribution characterized by a linear hazard-rate includes the one-parameter exponential and Rayleigh distributions. Usually the parameters of the linear hazard-rate model are estimated by the method of least squares. This work is concerned with Bayes estimation of the two-parameters from a type-2 censored sample. Monte Carlo simulation is used to compare the Bayes risk of the regression estimator with the minimum Bayes risk. Discrete mixtures of decreasing failure rate distributions are known to have decreasing failure rates. The authors prove that the result holds for continuous mixtures as well     

The mouse homolog of the human Miller-Dieker chromosomal region (MDCR) maps to mouse chromosome 11 in close proximity to Mov9 and D11Nds1

Tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and IL-1 have been shown to stimulate the synthesis of acute-phase proteins; however, few studies have examined the effect of these cytokines on gluconeogenesis. We investigated the effects of these cytokines on gluconeogenesis in primary cultures of rat hepatocytes. Incubation of hepatocytes for 24 hours with TNF-alpha or IL-1 alpha did not affect gluconeogenesis. Hepatocytes incubated with 100 pmol/L and 1 nmol/L IL-6 had a dose-dependent increase (P < .05) in gluconeogenesis (2.6 +/- 0.1 and 3.2 +/- 0.1 pmol/10(6) cells/min, respectively) as compared with controls (2.0 +/- 0.1).     

Structure-Activity Relationships of Benzamides and Isoindolines Designed as SARS-CoV Protease Inhibitors Effective against SARS-CoV-2

Inhibition of coronavirus (CoV)-encoded papain-like cysteine proteases (PL^pro) represents an attractive strategy to treat infections by these important human pathogens. Herein we report on structure-activity relationships (SAR) of the noncovalent active-site directed inhibitor (R)-5-amino-2-methyl-N-(1-(naphthalen-1-yl)ethyl) benzamide ( 2 b ), which is known to bind into the S3 and S4 pockets of the SARS-CoV PL^pro. Moreover, we report the discovery of isoindolines as a new class of potent PL^pro inhibitors. The studies also provide a deeper understanding of the binding modes of this inhibitor class. Importantly, the inhibitors were also confirmed to inhibit SARS-CoV-2 replication in cell culture suggesting that, due to the high structural similarities of the target proteases, inhibitors identified against SARS-CoV PL^pro are valuable starting points for the development of new pan-coronaviral inhibitors.     

Path‐space Motion Estimation and Decomposition for Robust Animation Filtering

Renderings of animation sequences with physics‐based Monte Carlo light transport simulations are exceedingly costly to generate frame‐by‐frame, yet much of this computation is highly redundant due to the strong coherence in space, time and among samples. A promising approach pursued in prior work entails subsampling the sequence in space, time, and number of samples, followed by image‐based spatio‐temporal upsampling and denoising. These methods can provide significant performance gains, though major issues remain: firstly, in a multiple scattering simulation, the final pixel color is the composite of many different light transport phenomena, and this conflicting information causes artifacts in image‐based methods. Secondly, motion vectors are needed to establish correspondence between the pixels in different frames, but it is unclear how to obtain them for most kinds of light paths (e.g. an object seen through a curved glass panel). To reduce these ambiguities, we propose a general decomposition framework, where the final pixel color is separated into components corresponding to disjoint subsets of the space of light paths. Each component is accompanied by motion vectors and other auxiliary features such as reflectance and surface normals. The motion vectors of specular paths are computed using a temporal extension of manifold exploration and the remaining components use a specialized variant of optical flow. Our experiments show that this decomposition leads to significant improvements in three image‐based applications: denoising, spatial upsampling, and temporal interpolation.     

Imposing temporal consistency on deep monocular body shape and pose estimation

Computational Visual Media - Accurate and temporally consistent modeling of human bodies is essential for a wide range of applications, including character animation, understanding human social...     

Berechnung und Optimierung von Geometrie und Eingriffsverhalten von Zahnformen beliebiger Achslage

The main benefit, the economical manufacturability of traditional gear profiles, such as an involute, are no longer of major importance in times of computer-aided design and production. Due to existing modern production techniques standard and more sophisticated gear types can be produced with high precision and maintainable financial effort. Especially for non-standard gear types modern gear production systems ensure high quality and reliability to the operator with regard to flank and meshing geometry. Depending on the context of application different gear types have advantages and disadvantages concerning load carrying capacity, effectiveness or noise excitation. Developing an optimized gearing for the desired application is thus a complex and elementary goal within the design process.     

Induction of chromosome shattering by ultraviolet irradiation and caffeine: comparison of whole-cell and partial-cell irradiation

Synchronized and asynchronously growing cells of a V79 sub-line of the Chinese hamster were either whole-cell irradiated ( gamma, 254 nm) or laser-UV-microirradiated ( gamma, 257 nm). Post-incubation with caffeine (1-2 mM) often resulted in chromosome shattering, which was a rare event in the absence of this compound. In experiments with caffeine, the following results were obtained. Shattering of all the chromosomes of a cell (generalized chromosome shattering, GCS) was induced by whole-cell irradiation at the first post-irradiation mitosis when the UV fluence exceeded a "threshold" value in the sensitive phases of the cell cycle (G1 and S). GCS was also induced by laser-UV-microirradiation of a small part of the nucleus in G1 or S whereas microirradiation of cytoplasm beside the nucleus was not effective. An upper limit of the UV fluence in the non-irradiated nuclear part due to scattering of the microbeam was experimentally obtained. This UV fluence was significantly below the threshold fluence necessary to induce GCS in whole-cell irradiation experiments. In other cells, partial nuclear irradiation resulted in shattering of a few chromosomes only, while the majority remained intact (partial chromosome shattering, PCS). G1/early S was the most sensitive phase for induction of GCS by whole-cell and partial nuclear irradiation. The frequency of PCS was observed to increase when partial nuclear irradiation was performed either at lower incident doses or at later stages of S. We suggest that PCS and GCS indicate 2 levels of chromosome damage which can be produced by the synergistic action of UV irradiation and caffeine. PCS may be restricted to microirradiated chromatin whereas GCS involves both irradiated and unirradiated chromosomes in the microirradiated nucleus.     

Helium liquefaction with a commercial 4 K Gifford-McMahon cryocooler

This paper describes helium liquefaction using a commercial cryocooler with 1.5 W cooling power at 4.2 K (Sumitomo model RDK415D with compressor CSW-71D, consuming 6.5 kW electrical power), equipped with heat exchangers for precooling the incoming gas. No additional cooling power of cryoliquids or additional Joule-Thomson stages were utilized. Measurements of the pressure dependence of the liquefaction rate were performed. A maximum value of 83.9 g/h was obtained for 2.25 bar stabilized input pressure. Including the time needed to cool the liquefied helium to 4.2 K at 1 bar after filling the bottle connected to the cold head, and correcting for heat screen influences, this results in a net liquefaction rate of 67.7 g/h. Maintaining a pressure close to 1 bar above the bath during liquefaction, a rate of 55.7 g/h was obtained. The simple design enables many applications of the apparatus.