The performance of a direct-sequence spread-spectrum acquisition system using a linear prediction filter for narrowband interference suppression

The coarse acquisition performance of a direct sequence spread-spectrum receiver is analyzed when a linear prediction filter is used for narrowband interference suppression. We show that once an appropriate matching strategy is identified, the linear prediction filter can provide favorable performance when narrowband interference is present over a considerable range of both interference power and bandwidth. In addition, the presence of the filter dramatically improves the performance over the case where there is no filter, except when the interference bandwidth and the power are both small (i.e., when the processing gain provides sufficient interference immunity without the filter). If long spreading sequences are used with moderately sized observation windows, the acquisition performance can be severely degraded when a parallel acquisition scheme is used due to the linear predication filter. We show, however, that a slower serial receiver will provide reliable performance.This work was supported in part by the Office of Naval Research under contract ONR N00014-91-J-1234, the Army Research Office under contract ARO DAAL03-91-0071, and the NSF Center for Ultra-High Speed Circuits and Systems (ICAS).     

Modeling of optical low coherence reflectometry recorded Braggreflectograms: evidence to a decisive role of Bragg spectral selectivity

This paper draws attention to the basic principles governing reflections in uniform Bragg reflectors (BR) when measured employing optical low coherence reflectometry (OLCR) technique. Using computations based on transfer matrix method (TMM), we first showed a strong spectral dependence of Bragg reflectograms on an OLCR probe spectrum. Later, this dependence is exploited to evaluate, for the first time, the coupling coefficient κ of a Bragg grating in a distributed Bragg reflector (DBR) laser on InP     

Rectal sexual trauma including foreign bodies

We used a potent and specific monoclonal antibody to somatostatin to test the physiologic inhibitory role of the tetradecapeptide somatostatin on pancreatic secretion. Somatostatin immunoneutralization increased both the total amylase and volume of pancreatic secretion. Cholecystokinin-A receptor antagonism abolished the stimulatory effect of somatostatin immunoneutralization. We conclude that somatostatin tonically inhibits, pancreatic secretion in fasted rats via inhibition of the release or action of cholecystokinin. Furthermore, the source of these peptides is likely islet delta cells and intrapancreatic neurons, respectively.     

Analysis of amyloid deposition in a transgenic mouse model of homozygous familial amyloidotic polyneuropathy

Amyloid fibrils derived from the Japanese, Portuguese, and Swedish types of familial amyloidotic polyneuropathy all consist of a variant transthyretin (TTR) with a substitution of methionine for valine at position 30 (TTR Met 30). In an attempt to establish an animal model of TTR Met-30-associated homozygous familial amyloidotic polyneuropathy and to study the structural and functional properties of human TTR Met 30, we generated a mouse line carrying a null mutation at the endogenous ttr locus (ttr-/-) and the human mutant ttr gene (6.0-hMet 30) as a transgene. In these mice, human TTR Met-30-derived amyloid deposits were first observed in the esophagus and stomach when the mice were 11 months of age. With advancing age, amyloid deposits extended to various other tissues. Because no significant difference was detected in the onset, progression, and tissue distribution of amyloid deposition between the ttr-/- and ttr+/+ transgenic mice expressing 6.0-hMet 30, endogenous normal mouse TTR probably does not affect the deposition of human TTR Met-30-derived amyloid in mice. TTR is a tetramer composed of four identical subunits that binds thyroxine (T4) and plasma retinol-binding protein. The introduction of 6.0-hMet 30 into the ttr-/- mice significantly increased their depressed serum levels of T4 and retinol-binding protein, suggesting that human TTR Met 30 binds T4 and retinol-binding protein in vivo. The T4-binding ability of human TTR Met 30 was confirmed by the analysis of T4-binding proteins in the sera of ttr-/- transgenic mice expressing 6.0-hMet 30. The T4-binding studies also demonstrated the presence of hybrid tetramers between mouse and human TTR subunits in the ttr+/+ transgenic mice expressing 6.0-hMet 30.     

Kinematics of heelstrike during walking and carrying: implications for slip resistance testing

Slip resistance measurements of shoes and floors are used to evaluate the potential for slip and fall injuries. These measurements are believed to have increased validity when they more closely reflect actual heelstrike biomechanics during locomotion. The purpose of this study was to describe heelstrike kinematics during load carrying to provide data towards improved slip resistance testing. Foot kinematics during load carrying (unladen and carrying from 0 to 13.5 kg) at various cadences (70, 90, 100 steps/min) was recorded. Measures before, during and after heelstrike were analysed. Cadence was an important predictor for all variables measured, associated with changes from 13% to over 100%. The load carried was an important predictor for only the heel slip distance after heelstrike, but this effect needs to be investigated further. These results can be used to improve the fidelity of slip resistance measurements, which is critical to reduce slip and fall injuries in the workplace or during activities of daily living.     

Structural analysis of substrate binding by the molecular chaperone DnaK

DnaK and other members of the 70-kilodalton heat-shock protein (hsp70) family promote protein folding, interaction, and translocation, both constitutively and in response to stress, by binding to unfolded polypeptide segments. These proteins have two functional units: a substrate-binding portion binds the polypeptide, and an adenosine triphosphatase portion facilitates substrate exchange. The crystal structure of a peptide complex with the substrate-binding unit of DnaK has now been determined at 2.0 angstroms resolution. The structure consists of a beta-sandwich subdomain followed by alpha-helical segments. The peptide is bound to DnaK in an extended conformation through a channel defined by loops from the beta sandwich. An alpha-helical domain stabilizes the complex, but does not contact the peptide directly. This domain is rotated in the molecules of a second crystal lattice, which suggests a model of conformation-dependent substrate binding that features a latch mechanism for maintaining long lifetime complexes.     

A novel design proposal to minimize reflections in deep-ridgemultimode interference couplers

We propose and demonstrate here the high efficiency of a novel design for deep-ridge multimode interference (MMI) couplers rendering them to behave like good transmitters with minimized reflections when integrated with emission devices. Using optical low-coherence reflectometry measurements, this novel design is shown to suppress to a great extent the highly detrimental internal resonance and often important backreflections inherent to even fully optimized deep-ridge MMIs