Course of functioning in adolescents 1 year after alcohol and other drug treatment.

Clinical course was studied in 131 male and female adolescents with current alcohol use disorder (AUD) at baseline (BL). Participants were classified into 4 groups according to their diagnosis and drinking pattern 1 year later. The 4 groups were compared with each other and with 37 community control participants. Results showed that over half of the clinical sample no longer had a current AUD at 1 year; about 64% were and 36% were not still drinking. BL discriminators of 1-year status were alcohol dependence, other drug use, and coping. All of the clinical groups tended to show improvement at 1 year in the main dependent variables, and the abstainers' level of drug use and coping were comparable with that of the community participants. These findings suggest that many adolescents improve in functioning during the 1 year after alcohol and drug treatment and that a stress and coping model is useful for studying clinical course of AUDs in adolescents. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Stability of orthopedic and surgically assisted rapid palatal expansion over time

At the present time no reports are available on the stability between orthopedic and surgically assisted rapid palatal expansion. This study was designed to examine and compare the dental and skeletal changes over time for both orthopedic maxillary expansion and surgically assisted palatal expansion. The study was divided into two groups. Group one was orthopedically expanded and consisted of 14 males and 10 females. The ages ranged from 6 years to 12 years with a mean of 8.5 years. Group two received surgically assisted rapid palatal expansion and consisted of 12 males and 16 females with ages ranging from 13 years to 35 years and a mean age of 19.25 years. All 52 subjects were white, from the same geographic area, and were treated by the same two operators. Dental models and posterior anterior cephalograms were obtained immediately before and after expansion, at removal of the expansion device, and 1 year after removal of the appliance. A repeated measures analysis of variance test was applied to assess changes over time between groups. The surgical and nonsurgical techniques displayed similar trends over time although the surgical group contained a greater quantity of expansion. Both the orthopedic and the surgical groups showed stable results.     

Analysis of change in adolescents involved in alcohol and drug treatment.

This study examined differences between statistical and clinically significant change. All participants were adolescent "drinkers" who were classified into 2 groups: those recruited from alcohol or drug treatment programs and with a diagnosis of current alcohol abuse or dependence, or those with no such diagnostic history, and no history of substance abuse treatment. The results showed statistically significant change in clinical participants from baseline to 1 yr on the 1 psychosocial adjustment and 3 drinking pattern measures. Additional analyses of clinically significant change greatly enhanced understanding of the level of functioning and degree of change in the clinical participants. The findings illustrate that use of such an approach increases the value of analyses of outcome data to the consumer. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Methods for providing probe position and temperature information onMR images during interventional procedures

Interventional magnetic resonance imaging (MRI) can be defined as the use of MR images for guiding and monitoring interventional procedures (e.g., biopsy, drainage) or minimally invasive therapy (e.g., thermal ablation). This work describes the development of a prototype graphical user interface and the appropriate software methods to accurately overlay a representation of a rigid interventional device [e.g., biopsy needle, radio-frequency (RF) probe] onto an MR image given only the probe's spatial position and orientation as determined from a three-dimensional (3-D) localizer used for interactive scan plane definition. This permits 1) “virtual tip tracking”, where the probe tip location is displayed on the image without the use of separate receiver coils or a “road map” image data set, and, 2) “extending” the probe to predict its path if it were directly moved forward toward the target tissue. Further, this paper describes the design and implementation of a method to facilitate the monitoring of thermal ablation procedures by displaying and overlaying temperature maps from temperature sensitive MR acquisitions. These methods provide rapid graphical updates of probe position and temperature changes to aid the physician during the actual interventional MRI procedures without altering the usual operation of the MR imager     

Discrete Dynamical System Framework for Construction of Connections between Critical Regions in Lattice Height Data

We define a new mathematical model for the topological study of lattice height data. A discrete multivalued dynamical system framework is used to establish discrete analogies of a Morse function, its gradient field, and its stable and unstable manifolds in order to interpret functions numerically given on finite sets of pixels. We present efficient algorithms detecting critical components of a height function f and displaying connections between them by means of a graph, called the Morse connections graph whose nodes represent the critical components of f and edges show the existence of connecting trajectories between nodes. This graph encodes efficiently the topological structure of the data and makes it easy to manipulate for subsequent processing.

A single-chip dual-band tri-mode CMOS transceiver for IEEE 802.11a/b/g wireless LAN

A single-chip dual-band tri-mode CMOS transceiver that implements the RF and analog front-end for an IEEE 802.11a/b/g wireless LAN is described. The chip is implemented in a 0.25-/spl mu/m CMOS technology and occupies a total silicon area of 23 mm/sup 2/. The IC transmits 9 dBm/8 dBm error vector magnitude (EVM)-compliant output power for a 64-QAM OFDM signal. The overall receiver noise figure is 5.5/4.5 dB at 5 GHz/2.4 GHz. The phase noise is -105 dBc/Hz at a 10-kHz offset and the spurs are below -64 dBc when measured at the 5-GHz transmitter output.     

Assessment of relationship-specific incentive and threat sensitivities: Predicting satisfaction and affect in adult intimate relationships.

Self-report scales assessing relationship-specific incentive and threat sensitivity were created. Initial tests of factor structure and associations with relationship quality were conducted in a sample of persons in intimate relationships (Study 1). Associations with conceptually related measures were examined to determine convergent and discriminant validity in a sample of dating couples (Study 2). Cross-validation of the factor structure was established in engaged couples (Study 3) and in newlywed couples (Study 4). In Study 4, couples also engaged in a laboratory-based threat task (discussion about a significant marital problem) and incentive task (discussion about loving aspects of the partner/marriage). Relationship incentive sensitivity predicted higher positive affect after the incentive task for both husbands and wives. Relationship threat sensitivity predicted greater anxiety in response to the threat laboratory task for wives only. Implications of approach and avoidance motivations in close relationship processes and outcomes are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Estradiol-17β Regulates Expression of Luteal DNA Methyltransferases and Genes Involved in the Porcine Corpus Luteum Function In Vivo

The corpus luteum (CL) is a temporary endocrine gland vital for pregnancy establishment and maintenance. Estradiol-17β (E2) is the major embryonic signal in pigs supporting the CL’s function. The mechanisms of the luteoprotective action of E2 are still unclear. The present study aimed to determine the effect of E2 on luteal expression of factors involved in CL function. An in vivo model of intrauterine E2 infusions was applied. Gilts on day 12 of pregnancy and the estrous cycle were used as referential groups. Concentrations of E2 and progesterone were elevated in CLs of gilts receiving E2 infusions, compared to placebo-treated gilts. Estradiol-17β stimulated luteal expression of DNA-methyltransferase 1 (DNMT1), but decreased expression of DNMT3B gene and protein, as well as DNMT3A protein. Similar results for DNMT3A and 3B were observed in CLs on day 12 of pregnancy compared to day 12 of the estrous cycle. Intrauterine infusions of E2 altered luteal expression of the genes involved in CL function: PTGFR, PTGES, STAR, HSD17B1, CYP19A1, and PGRMC1. Our findings indicate a role for E2 in expression regulation of factors related to CL function and a novel potential for E2 to regulate DNA methylation as putative physiological mechanisms controlling luteal gene expression.