Relationship between seizure frequency and costs and quality of life of outpatients with partial epilepsy in France, Germany, and the United Kingdom

PURPOSE: The relationship between seizure frequency and both health care costs and quality of life (QOL) was investigated in a retrospective, cross-sectional, multicenter study in France, Germany, and the United Kingdom. METHODS: Three hundred outpatients with stable partial epilepsy were approximately evenly distributed among five seizure-frequency groups, ranging from seizure-free in the last 3 months (group 1) to daily seizures (group 5). Economic data, obtained through patient interviews and record abstraction, comprised direct medical costs, direct nonmedical costs, and indirect costs for the preceding 3 months. Total societal costs in the three countries were pooled and converted to United States dollar equivalents. QOL was assessed through a self-administered questionnaire, the Functional Status Questionnaire (FSQ). RESULTS: Mean total costs increased from $780 in group 1 to $2,171 in group 5 (p = 0.0001), with significant increases in each cost category as seizure frequency increased. Greater seizure frequency also significantly (p = 0.0270) correlated with lower employment rates, which ranged from 57% in group 1 to 30% in group 5. QOL declined as seizure frequency increased. Particularly affected were basic and intermediate activities of daily living (ADL), mental health, social activity, and feeling about health. CONCLUSIONS: The study results show that higher seizure frequencies are associated with higher direct and indirect costs and with reduced QOL for patients with epilepsy.     

Radiation pattern of fluorescence from molecules embedded in small particles: general case

A method is presented for calculating and analyzing the angular distribution of fluorescent emission from randomly oriented anisotropic molecules embedded in small dielectric particles with the nonzero reorientation angle between absorption and emission moments suggested by physical considerations now taken into account. Calculations performed on the basis of this method are compared with some of the available experimental data for fluorescent dye molecules embedded in microspheres, and good quantitative agreement is found. It is shown how fitting the computed results to experimental data determines an effective reorientation angle between absorption and emission transition moments. A more definitive test to which the model could be subjected is described.     

The doormat effect: When forgiving erodes self-respect and self-concept clarity.

[Correction Notice: An erratum for this article was reported in Vol 99(1) of Journal of Personality and Social Psychology (see record 2010-12776-008). The graphs in Figure 2, on p. 741, and the graphs in Figure 3, on p. 742, were switched. The corrected figures in their entirety appear in the erratum.] We build on principles from interdependence theory and evolutionary psychology to propose that forgiving bolsters one's self-respect and self-concept clarity if the perpetrator has acted in a manner that signals that the victim will be safe and valued in a continued relationship with the perpetrator but that forgiving diminishes one's self-respect and self-concept clarity if the perpetrator has not. Study 1 employed a longitudinal design to demonstrate that the association of marital forgiveness with trajectories of self-respect over the first 5 years of marriage depends on the spouse's dispositional tendency to indicate that the partner will be safe and valued (i.e., agreeableness). Studies 2 and 3 employed experimental procedures to demonstrate that the effects of forgiveness on self-respect and self-concept clarity depend on the perpetrator's event-specific indication that the victim will be safe and valued (i.e., amends). Study 4 employed a longitudinal design to demonstrate that the association of forgiveness with subsequent self-respect and self-concept clarity similarly depends on the extent to which the perpetrator has made amends. These studies reveal that, under some circumstances, forgiveness negatively impacts the self. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A comparison of MMPI-2 validity in African American and Caucasian psychiatric inpatients.

This study investigated ethnic differences on the Minnesota Multiphasic Personality Inventory-2 (MMPT-2) in 229 African American and 1,558 Caucasian psychiatric inpatients. Mean differences were found on several MMPI-2 validity and clinical scales. These were generally consistent with differences between the groups, indicated by the available extratest criterion data. To identify potential bias, the authors conducted 65 step-down hierarchical multiple regression analyses, predicting conceptually relevant clinical criteria from either MMPI-2 clinical or content scales for each gender. A number of MMPI-2 scales evidenced bias reflecting minor underprediction of psychopathology in African Americans. It is important to note that, in almost all cases, the magnitude of these differences was small and not clinically significant. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Multi-tier service restoration through network reconfiguration andcapacitor control for large-scale radial distribution networks

A fast and effective service restoration algorithm allowing multi-tier or system-wide switching and capacitor control actions is developed for large-scale, radial distribution networks. The service restoration problem is formulated as a constrained multiple-objective optimization problem. A solution algorithm designed to consider networks with predominately manual switches is developed which utilizes information calculated from three-phase power flow analysis to restore as much priority and total load as possible while requiring a minimal number of control actions and amount of geographic travel distance. Simulation results are presented for a 399 bus distribution network and compared to the service restoration algorithm which avoided multi-tier switching     

Six rules of debt management for dentists

A modification of von Willebrand' factor/ristocetin cofactor activity test is proposed. Agglutination of formalin-treated platelets is monitored in the aggregation analyzer from changes in the light transmission in the specimen. The test is sensitive and reproducible. It is intended for clinical laboratories to be used in patients with hematological diseases and the endotheliopathy syndrome of different etiology.