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1.
OBJECTIVE: To study the effects of an aldose reductase inhibitor (ARI-509, Wyeth-Ayerst, Princeton, NJ) and aminoguanidine (AMG), agents that have been reported to prevent or delay diabetic retinopathy, on retinal vascular abnormalities and the immunocytochemical expression in the retina of vascular endothelial growth factor (VEGF) in rats maintained for up to 2 years on a 50% galactose diet. METHODS: Albino rats were placed on a control diet, a diet containing 50% galactose, or the 50% galactose diet containing either ARI-509 or AMG. Treatment with ARI-509 or AMG was initiated at the beginning of the experiment or after 12 months of galactose feeding. After 22 to 24 months, the rats were killed and the retinal vasculature from half of one eye was isolated by trypsin-elastase digestion for semiquantitative evaluation of retinal vascular lesions. The other half of the retina was prepared for immunocytochemistry and stained for the presence of VEGF, factor VIII, vimentin, and glial fibrillary acidic protein. Red blood cells, sciatic nerves, and a portion of the retina from the second eye were assayed for glucose, galactose, fructose, sorbitol, galactitol, and myo-inositol. Red blood cells were also assayed for galactosylated hemoglobin. RESULTS: Galactose-fed animals developed a vascular retinopathy characterized by severe cellular loss in the retinal capillaries and intensification of periodic acid-Schiff staining of the vascular basement membranes. Some animals also displayed dilation and hypercellularity of vessels in the posterior retina. These changes were substantially reduced in animals receiving ARI-509 from the beginning of the galactose diet, but were unaffected in all of the other treatment groups. None of the rats receiving ARI-509 or AMG treatment, whether initiated from the onset or after 12 months of galactosemia, demonstrated VEGF immunoreactivity. With the exception of the animals receiving ARI-509 from the beginning of the experiment, all of the galactose-fed animals developed dense cataracts within 6 weeks of the beginning of the galactose diet. Galactitol levels in animals receiving ARI-509 were 86% to 93% lower in red blood cells, retina, and sciatic nerve than those in the other galactose-fed groups. CONCLUSIONS: Although ARI-509 and AMG have different abilities to delay or prevent the diabetic-like retinopathy in galactosemic rats, even when substantial retinal microvascular acellularity occurs, both drugs prevent the immunocytochemical expression of VEGF. These results suggest that factors other than hypoxia may be responsible for VEGF expression in the retina, and that aldose reductase inhibitors and AMG have potential roles in preventing such expression and, thus, perhaps preventing retinal neovascularization. 相似文献
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Bound-state beta decay of highly ionized atoms 总被引:1,自引:0,他引:1
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The occurrence of fungi was investigated in the gut of 200 common garden lizards (Agama agama). The most important pathogenic fungus isolated was Basidiobolus haptosporus, an aetiological agent of subcutaneous zygomycosis. It was recovered from the intestinal contents of 112 (56%) lizards. Other important fungi isolated included Aspergillus spp. in 24 (12%) lizards, Candida spp. in 12 (6%), Penicillium spp. in 12 (6%) and Fusarium spp. in 12 (6%). Mucor spp. were isolated from eight (4%) male lizards only. Agamid lizards are plentiful in rural and urban areas of Nigeria. As they live in close vicinity to man, they are likely to play an important role in the spread of disease that may be caused by these fungi and its transmission to man. None of the animals investigated that yielded fungal cultures revealed any external fungal infection. 相似文献
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J Zaloudík I Kocák Z Pacovsky P Karásek V Fait H Bartonková M Nekulová 《Canadian Metallurgical Quarterly》1997,43(3):171-172
In the absence of adequate autogenous vein for tibial artery bypass in limb salvage surgery, the use of prosthetic grafts with a distal anastomotic vein cuff or patch has shown promising results. Here, we describe how the Florester Internal Vessel Occluder (Meadox UK, Bedfordshire, UK) can facilitate the construction of a distal anastomotic vein cuff. 相似文献
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S. Kar T. Searles E. Lee G. B. Viswanathan H. L. Fraser J. Tiley R. Banerjee 《Metallurgical and Materials Transactions A》2006,37(3):559-566
The development of a set of computational tools that permit microstructurally based predictions for the tensile properties
of commercially important titanium alloys, such as Ti-6Al-4V, is a valuable step toward the accelerated maturation of materials.
This paper will discuss the development of neural network models based on a Bayesian framework to predict the yield and ultimate
tensile strengths of Ti-6Al-4V at room temperature. The development of such rules-based model requires the population of extensive
databases, which in the present case are microstructurally based. The steps involved in database development include producing
controlled variations of the microstructure using novel approaches to heat treatments, the use of standardized stereology
protocols to characterize and quantify microstructural features rapidly, and mechanical testing of the heat-treated specimens.
These databases have been used to train and test neural network models for prediction of tensile properties. In addition,
these models have been used to identify the influence of individual microstructural features on the tensile properties, consequently
guiding the efforts toward development of more robust mechanistically based models. Based on the neural network model, it
is possible to investigate the influence of individual microstructural features on the tensile properties, and in certain
cases these dependencies can point toward unrecognized phenomena. For example, the apparently unexpected trend of increase
in tensile strength with increasing prior β-grain size has led to the determination of the pronounced role of the basketweave microstructure in strengthening these alloys,
especially in case of larger prior β grains.
This article is based on a presentation made in the symposium “Computational Aspects of Mechanical Properties of Materials,”
which occurred at the 2005 TMS Annual Meeting, February 13–17, 2005, in San Francisco, CA, under the auspices of the MPMD-Computational
Materials Science & Engineering (Jt. ASM-MSCTS) Committee. 相似文献
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