Looking back: a history of marine seismic exploration

Seismic exploration instruments and geophysical techniques developed in the 20th century have dramatically expanded our knowledge of the oceanic crust. This article is a review of the history, development and implementation of these tools     

Waste energy recovery: An excellent investment opportunity

As energy costs increase, harnessing of waste energy in an efficient manner is becoming increasingly more important. This paper presents a new perspective on the use of Rankine cycles as applied to thermal energy from industrial waste heat and renewable sources. It shows that Rankine cycles can efficiently and in a cost-effective manner convert waste energy to power, heat pumping and cogeneration. Economics of waste energy recovery are discussed and examples of several applications are cited. It points out that life cycle cost of equipment is a more rational purchasing criteria than the first cost. Conclusions and recommendations are given for a more rapid commercialization on these new energy conserving systems.     

How not to do research: or How I escaped alive from a social service agency.

Relates a personal experience of being in charge of a research project in a social service agency. Problems encountered included lack of office space and equipment, hiring of assistants, and conflicting views of project personnel. (0 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Establishment and characterization of a novel human myoepithelial cell line and matrix-producing xenograft from a parotid basal cell adenocarcinoma

Myoepithelial cells exert important paracrine effects on epithelial morphogenesis and mitogenesis through direct cell-cell interactions and through synthesis of a basement membrane extracellular matrix. To study these effects further, this study established the first immortalized human myoepithelial cell line, HMS-1, and transplantable xenograft, HMS-X, from the rare parotid basal cell adenocarcinoma. The cell line exhibited a fully differentiated myoepithelial phenotype and the xenograft exhibited the rare property of accumulating an abundant extracellular matrix composed of both basement membrane and nonbasement membrane components with the latter predominating. With HMS-1 as a feeder layer, dramatic and specific induction of epithelial morphogenesis (spheroid formation) occurred with selected normal epithelial and primary carcinoma target cells. HMS-1 and HMS-X provide distinct advantages over the conventional murine matrices in existence. They will be invaluable in future studies of human tumor-myoepithelial and matrix interactions important for tumor cell growth, invasion, and metastasis.     

The human myoepithelial cell is a natural tumor suppressor

Myoepithelial cells, which surround ducts and acini of glandular organs, form a natural border separating proliferating epithelial cells from basement membrane and underlying stroma. Myoepithelial cells in situ and in vitro constitutively express high amounts of proteinase inhibitors that include tissue inhibitor of metalloproteinase 1, protease nexin-II, alpha-1 antitrypsin, and maspin. Human myoepithelial xenografts (HMS-X, HMS-3X, and HMS-4X), which our laboratory has established, accumulate an abundant extracellular matrix containing sequestered proteinase inhibitors. Humatrix, a gel that we have derived from HMS-X, inhibits tumor cell invasion (down to 25% +/- 10% of Matrigel control; P < 0.01), and our recently established human myoepithelial cell lines, HMS-1, HMS-3, and HMS-4, inhibit tumor cell invasion in cellular invasion (down to 42% +/- 7% of control; P < 0.05) and in conditioned media assays (down to 30% +/- 8% of control; P < 0.01). The anti-invasive effects of HMS-1, HMS-3, and HMS-4 can be enhanced by phorbol 12-myristate 13-acetate (down to 2% +/- 1% of control) by a maspin-dependent mechanism and abolished by dexamethasone (up to 95% +/- 5% of control) by a maspin-independent mechanism (P < 0.01). HMS-X, HMS-3X, HMS-4X, and Humatrix inhibit tumor invasion and metastasis in severe combined immunodeficient mice (P < 0.001). The cumulative data suggest that myoepithelial cells are natural paracrine suppressors of invasion and metastasis and may specifically inhibit the progression of precancerous disease states to invasive cancer in vivo.     

Retarding Effects of Institutionalization upon the Clinical Psychologist.

Reports on a count of the psychological reports--and the average number of words per report--completed by the author, a civil service staff psychologist working within a state school for the mentally retarded, over a period of 4 years. The work of the clinical psychologist in this setting involves primarily testing and evaluation. The neatly descending hierarchy of both number of reports and average quantity per report testifies to the insidious effects of institutional rut, at least upon assessment procedures. (PsycINFO Database Record (c) 2010 APA, all rights reserved)