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排序方式: 共有1119条查询结果,搜索用时 15 毫秒
1.
Raquel Cano Jos L. Prez Liss Angarita Dvila ngel Ortega Yosselin Gmez Nereida Josefina Valero-Cedeo Heliana Parra Alexander Manzano Teresa Isabel Vliz Castro María P. Díaz Albornoz Gabriel Cano Joselyn Rojas-Quintero Maricarmen Chacín Valmore Bermúdez 《International journal of molecular sciences》2021,22(9)
Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver disorder, affecting around 25% of the population worldwide. It is a complex disease spectrum, closely linked with other conditions such as obesity, insulin resistance, type 2 diabetes mellitus, and metabolic syndrome, which may increase liver-related mortality. In light of this, numerous efforts have been carried out in recent years in order to clarify its pathogenesis and create new prevention strategies. Currently, the essential role of environmental pollutants in NAFLD development is recognized. Particularly, endocrine-disrupting chemicals (EDCs) have a notable influence. EDCs can be classified as natural (phytoestrogens, genistein, and coumestrol) or synthetic, and the latter ones can be further subdivided into industrial (dioxins, polychlorinated biphenyls, and alkylphenols), agricultural (pesticides, insecticides, herbicides, and fungicides), residential (phthalates, polybrominated biphenyls, and bisphenol A), and pharmaceutical (parabens). Several experimental models have proposed a mechanism involving this group of substances with the disruption of hepatic metabolism, which promotes NAFLD. These include an imbalance between lipid influx/efflux in the liver, mitochondrial dysfunction, liver inflammation, and epigenetic reprogramming. It can be concluded that exposure to EDCs might play a crucial role in NAFLD initiation and evolution. However, further investigations supporting these effects in humans are required. 相似文献
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Billardon M. Elleaume P. Ortega J. Bazin C. Bergher M. Velghe M. Deacon D. Petroff Y. 《Quantum Electronics, IEEE Journal of》1985,21(7):805-823
In this paper we review the results obtained in the last two years with the Orsay free electron laser. 相似文献
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RM Martín‐Aranda E Ortega‐Cantero ML Rojas‐Cervantes MA Vicente‐Rodríguez MA Baares‐Muoz 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2005,80(2):234-238
α,β‐Unsaturated nitriles have been synthesized by Knoevenagel condensation of a carbonylic compound with malononitrile, assisted by sonochemical irradiation. Two alkaline‐promoted clays (Li+‐ and Cs+‐exchanged saponites) have been employed as catalysts. The influence of the carbonylic compound (benzaldehyde or cyclohexanone) and the use of a solvent on the catalytic activity have been studied. Remarkable increase in the conversion values has been found when the reaction is activated by ultrasound, as compared with the thermal activation. In this green, solvent‐free procedure, α,β‐unsaturated nitriles have been produced in very high yields (97%) when the Cs+‐saponite is used as catalyst. Copyright © 2004 Society of Chemical Industry 相似文献
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The stabilization problem for selected relative equilibria of an underactuated rigid body, modelling a simple underwater vehicle, moving in an ideal fluid is addressed. State feedback control laws achieving local asymptotic stability of a forward motion and of a diving/rising with forward/reverse motion are proposed. The control design exploits the Hamiltonian nature of the system to be controlled and it is based on the so-called interconnection and damping assignment (IDA) procedure. Simulation results complete the work. 相似文献
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The present study was undertaken to evaluate the postoperative relapse from the period of unwiring to 1 year postoperatively and its correlation to the amount of mandibular setback and change in vertical dimension after mandibular bilateral sagittal split osteotomy. Twenty-seven patients were evaluated cephalometrically by the time preoperatively, 6 weeks, 6 months and 1 year postoperatively. It was found that 1) the average amount of mandibular setback at pogonion point, 6 weeks postoperatively, is 7.6mm backward and 1.9mm downward, 2) the average amount of horizontal relapse at pogonion point, 6 months and 1 year postoperatively, are 1.9mm and 2.3mm respectively. 86% of the horizontal relapse, 1 year postoperatively, occurs in the first 6 months after removal of intermaxillary fixation, 3) the average amount of vertical relapse at pogonion point, 6 months and 1 year postoperatively, are 0.9mm and 1.1mm upward. 82% of the vertical relapse, 1 year postoperatively, occurs in the first 6 months after removal of intermaxillary fixation, 4) the amount of 1 year postoperatively horizontal relapse is significantly correlated both with the amount of horizontal mandibular set back and vertical downward change (r = 0.58, 0.67, p < 0.001), whereas the amount of vertical relapse is with the vertical downward change only, but horizontal setback isn't. 相似文献
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Vicente Rodríguez Montequín Francisco Ortega Fernández Nicolás Abajo de Martínez Juan Antonio González Rodríguez 《JOM Journal of the Minerals, Metals and Materials Society》2002,54(7):46-50
This research summary discusses the application of neural networks, evolutionary strategies, and other artificial intelligence
techniques in the modeling and optimization of the models used for temperature, rolling force, and torque calculation in heavy
plate milling. 相似文献
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