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排序方式: 共有1765条查询结果,搜索用时 31 毫秒
1.
Ji Hye Yang Sae Kwang Ku IL Je Cho Je Hyeon Lee Chang-Su Na Sung Hwan Ki 《International journal of molecular sciences》2021,22(4)
Hepatic fibrosis occurs when liver tissue becomes scarred from repetitive liver injury and inflammatory responses; it can progress to cirrhosis and eventually to hepatocellular carcinoma. Previously, we reported that neoagarooligosaccharides (NAOs), produced by the hydrolysis of agar by β-agarases, have hepatoprotective effects against acetaminophen overdose-induced acute liver injury. However, the effect of NAOs on chronic liver injury, including hepatic fibrosis, has not yet been elucidated. Therefore, we examined whether NAOs protect against fibrogenesis in vitro and in vivo. NAOs ameliorated PAI-1, α-SMA, CTGF and fibronectin protein expression and decreased mRNA levels of fibrogenic genes in TGF-β-treated LX-2 cells. Furthermore, downstream of TGF-β, the Smad signaling pathway was inhibited by NAOs in LX-2 cells. Treatment with NAOs diminished the severity of hepatic injury, as evidenced by reduction in serum alanine aminotransferase and aspartate aminotransferase levels, in carbon tetrachloride (CCl4)-induced liver fibrosis mouse models. Moreover, NAOs markedly blocked histopathological changes and collagen accumulation, as shown by H&E and Sirius red staining, respectively. Finally, NAOs antagonized the CCl4-induced upregulation of the protein and mRNA levels of fibrogenic genes in the liver. In conclusion, our findings suggest that NAOs may be a promising candidate for the prevention and treatment of chronic liver injury via inhibition of the TGF-β/Smad signaling pathway. 相似文献
2.
Multidimensional Systems and Signal Processing - The paper is devoted to the development of the octonion Fourier transform (OFT) theory initiated in 2011 in articles by Hahn and Snopek. It is also... 相似文献
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4.
Yi‐Hung Chen Ching‐Yuan Chang Wei‐Ling Su Chun‐Yu Chiu Yue‐Hwa Yu Pen‐Chi Chiang Chiung‐Fen Chang Je‐Lueng Shie Chyow‐San Chiou Sally IM Chiang 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2005,80(1):68-75
This study investigates the ozonation of CI Reactive Black 5 (RB5) by using the rotating packed bed (RPB) and completely stirred tank reactor (CSTR) as ozone contactors. The RPB, which provides high gravitational force by adjusting the rotational speed, was employed as a novel ozone contactor. The same ozone dosage was separately introduced into either the RPB or the CSTR for the investigation, while the experimental solution was continuously circulated within the apparatus consisting of the RPB and CSTR. The decolorization and mineralization efficiencies of RB5 in the course of ozonation are compared for these two methods. Moreover, the dissolved and off‐gas ozone concentrations were simultaneously monitored for the further analysis. As a result, the ozone mass transfer rate per unit volume of the RPB was significantly higher because of its higher mass transfer coefficient and gas–liquid concentration driving force. Furthermore, ozonation kinetics was found to be independent of the gravitational magnitude of an ozone gas–liquid contactor. Therefore, the results suggest employing RPBs as ozone‐contacting devices with the advantage of volume reduction. The experimental results, which can be used for further modeling of the ozonation process in the RPB, also show the requirement of correct design for the RPB. Consequently, the present study is useful for the understanding of practical application of RPBs. Copyright © 2004 Society of Chemical Industry 相似文献
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6.
Elżbieta Chmiel‐Szukiewicz 《应用聚合物科学杂志》2008,109(3):1708-1713
Attempts of obtaining of polyurethane foams using polyetherols with 1,3‐pyrimidine ring (obtained in reactions of 6‐aminouracil with oxiranes) are reported. Properties of the foams are investigated, especially their thermal stability. The foams show an improved thermal stability up to 200°C for a long time. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008 相似文献
7.
Teresa Mikołajczyk Grażyna Janowska Mariusz Wójcik Maciej Boguń Andrzej Kurzak 《应用聚合物科学杂志》2008,109(4):2513-2521
The rheological properties of spinning solutions of polyacrylonitrile in dimethyl formamide (DMF) containing various amounts of a ferromagnetic nanoaddition were investigated. The porous structure, the strength and thermal properties of fibers obtained from these solutions were assessed, as well as the uniformity of the nanoaddition distribution on the fiber surface was estimated. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008 相似文献
8.
Polymeric oxidants in the bead form that were macroporous styrene/divinylbenzene copolymers containing N‐chlorosulfonamide functional groups (in sodium or hydrogen form) or N‐bromosulfonamide groups (in sodium form) were synthesized and investigated to determine their oxidizing powers. The redox potentials of the N‐chlorosulfonamide/sulfonamide and N‐bromosulfonamide/sulfonamide systems were determined by potentiometric studies at different pH values with aqueous solutions of Na2SO3, KCN, and KSCN as reducers. The formal redox potentials of the N‐chlorosulfonamide copolymers were 0.79, 0.44, and ?0.12 V at pH's of 1.8, 8.45, and 13.6, respectively. The formal redox potential of the N‐bromosulfonamide copolymer was about 100 mV higher in comparable conditions and in solutions over pH = 5 (e.g., 0.56 V at pH = 8.56). The comparatively higher oxidizing power of the N‐bromosulfonamide copolymer was particularly evident in a strong alkaline medium (in which the N‐chlorosulfonamide copolymer was not reactive). In contrast, the N‐chlorosulfonamide copolymer showed strong oxidative properties in acidic media (in which the N‐bromosulfonamide copolymer decomposed itself). © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2008 相似文献
9.
Norman Fenton Martin Neil William Marsh Peter Hearty Łukasz Radliński Paul Krause 《Empirical Software Engineering》2008,13(5):499-537
Standard practice in building models in software engineering normally involves three steps: collecting domain knowledge (previous
results, expert knowledge); building a skeleton of the model based on step 1 including as yet unknown parameters; estimating
the model parameters using historical data. Our experience shows that it is extremely difficult to obtain reliable data of
the required granularity, or of the required volume with which we could later generalize our conclusions. Therefore, in searching
for a method for building a model we cannot consider methods requiring large volumes of data. This paper discusses an experiment
to develop a causal model (Bayesian net) for predicting the number of residual defects that are likely to be found during
independent testing or operational usage. The approach supports (1) and (2), does not require (3), yet still makes accurate
defect predictions (an R
2 of 0.93 between predicted and actual defects). Since our method does not require detailed domain knowledge it can be applied
very early in the process life cycle. The model incorporates a set of quantitative and qualitative factors describing a project
and its development process, which are inputs to the model. The model variables, as well as the relationships between them,
were identified as part of a major collaborative project. A dataset, elicited from 31 completed software projects in the consumer
electronics industry, was gathered using a questionnaire distributed to managers of recent projects. We used this dataset
to validate the model by analyzing several popular evaluation measures (R
2, measures based on the relative error and Pred). The validation results also confirm the need for using the qualitative factors
in the model. The dataset may be of interest to other researchers evaluating models with similar aims. Based on some typical
scenarios we demonstrate how the model can be used for better decision support in operational environments. We also performed
sensitivity analysis in which we identified the most influential variables on the number of residual defects. This showed
that the project size, scale of distributed communication and the project complexity cause the most of variation in number
of defects in our model. We make both the dataset and causal model available for research use. 相似文献
10.
Iwo H. Krzyżanowski 《Journal of Low Temperature Physics》1986,65(5-6):375-388
The unitary singlet-triplet states of superfluid Fermi liquids are investigated in the presence of strong magnetic fields. The static spin susceptibility is calculated in the limith 0 in the framework of the weak coupling approximation. It is predicted that BS (a mixture of the Balian- Werthamer anisotropic state andD-wave singlet state) and 2DS (a mixture of the planar 2D state andD-wave singlet state) spin singlet-triplet states become stable at some temperatures and magnetic fields. 相似文献