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排序方式: 共有400条查询结果,搜索用时 15 毫秒
1.
Pierre Santucci Christina Dedaki Alexandros Athanasoulis Laura Gallorini Anaïs Munoz Dr. Stéphane Canaan Dr. Jean-François Cavalier Dr. Victoria Magrioti 《ChemMedChem》2019,14(3):349-358
In the quest for new antibacterial agents, a series of novel long- and medium-chain mono- and disubstituted β-lactones was developed. Their activity against three pathogenic mycobacteria—M. abscessus, M. marinum, and M. tuberculosis—was assessed by the resazurin microtiter assay (REMA). Among the 16 β-lactones synthesized, only 3-hexadecyloxetan-2-one (VM005) exhibited promising activity against M. abscessus, whereas most of the β-lactones showed interesting activities against M. marinum, similar to that of the classical antibiotic, isoniazid. Regarding M. tuberculosis, six compounds were found to be active against this mycobacterium, with β-lactone VM008 [trans-(Z)-3-(hexadec-7-en-1-yl)-4-propyloxetan-2-one] being the best growth inhibitor. The promising antibacterial activities of the best compounds in this series suggest that these molecules may serve as leads for the development of much more efficient antimycobacterial agents. 相似文献
2.
Alexandros Papadopoulos Issaak Parcharidis Panagiotis Elias Pierre Briole 《International journal of remote sensing》2019,40(16):6365-6382
We analysed the ground deformation across two blocks defined by the Rio-Patras fault from 1993 to 2017 using multi-temporal Synthetic Aperture Radar Interferometry (InSAR) techniques. Our main objective was to contribute to the assessment of seismic hazard near the large city of Patras. Multiple data-sets were used, each one covering different temporal periods. Descending and ascending acquisitions, providing different viewing geometries contribute to fully determine the ground displacement in 3D. The data-sets used are from the European Space Agency’s (ESA) European Remote Sensing (ERS), Environmental Satellite (ENVISAT) and SENTINEL-1 as well as German Aerospace Center (DLR) ’s TERRASAR-X missions. Considering ESA’s missions covering both acquisition geometries and long periods, the southern block, showing lack of a sufficient number of scatterers does not allow the displacement characterization. In contrary, the northern block is characterized by a high number of scatterers having values of maximum likehood ranging from ?3.5 to ?4.3 mm year?1 for ascending geometry and from ?1.6 to ?2.7 mm year?1 for the descending one. The fact that both geometries show negative values of displacements are consistent with downlift movement and at the same time the quantitative differentiation probably indicates an horizontal component as well. 相似文献
3.
Suitability,efficiency and microbiological safety of novel physical technologies for the processing of ready‐to‐eat meals,meats and pumpable products
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Alexandros Ch. Stratakos Anastasios Koidis 《International Journal of Food Science & Technology》2015,50(6):1283-1302
Consumer studies and market reports show an increase in consumption of ready‐to‐eat (RTE) foods. Although conventional processing technologies can in most cases produce safe products, they can also lead to the degradation of nutritional compounds and negatively affect quality characteristics. Consumers strongly prefer food that is minimally processed with the maximum amount of health‐promoting substances. Novel processing technologies as pre‐ or post‐treatment decontamination methods or as substitutes of conventional technologies have the potential to produce foods that are safe, rich in nutrient content and with superior organoleptic properties. Combining novel with conventional processes can eliminate potential drawbacks of novel technologies. This review examines available scientific information and critically evaluates the suitability and efficiency of various novel thermal and nonthermal technologies in terms of microbial safety, quality as well as nutrient content on the production of RTE meals, meats and pumpable products. 相似文献
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What is the value of a scientist and its impact upon the scientific thinking? How can we measure the prestige of a journal or a conference? The evaluation of the scientific work of a scientist and the estimation of the quality of a journal or conference has long attracted significant interest, due to the benefits by obtaining an unbiased and fair criterion. Although it appears to be simple, defining a quality metric is not an easy task. To overcome the disadvantages of the present metrics used for ranking scientists and journals, J. E. Hirsch proposed a pioneering metric, the now famous h-index. In this article we demonstrate several inefficiencies of this index and develop a pair of generalizations and effective variants of it to deal with scientist ranking and publication forum ranking. The new citation indices are able to disclose trendsetters in scientific research, as well as researchers that constantly shape their field with their influential work, no matter how old they are. We exhibit the effectiveness and the benefits of the new indices to unfold the full potential of the h-index, with extensive experimental results obtained from the DBLP, a widely known on-line digital library. 相似文献
6.
Papatheodorou Nikolaos Kouroupetroglou Georgios Pino Alexandros Giannopoulos Panagiotis-Alexios Makris Gerasimos Papageorgiou Charalambos 《Universal Access in the Information Society》2021,20(2):321-331
Universal Access in the Information Society - We present an investigation of the systematic differences in upper limb motor skills between children with learning disabilities (LDs) and children... 相似文献
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George Roumelis Antonio Corral Michael Vassilakopoulos Yannis Manolopoulos 《GeoInformatica》2016,20(4):571-628
Efficient and effective processing of the distance-based join query (DJQ) is of great importance in spatial databases due to the wide area of applications that may address such queries (mapping, urban planning, transportation planning, resource management, etc.). The most representative and studied DJQs are the K Closest Pairs Query (KCPQ) and εDistance Join Query (εDJQ). These spatial queries involve two spatial data sets and a distance function to measure the degree of closeness, along with a given number of pairs in the final result (K) or a distance threshold (ε). In this paper, we propose four new plane-sweep-based algorithms for KCPQs and their extensions for εDJQs in the context of spatial databases, without the use of an index for any of the two disk-resident data sets (since, building and using indexes is not always in favor of processing performance). They employ a combination of plane-sweep algorithms and space partitioning techniques to join the data sets. Finally, we present results of an extensive experimental study, that compares the efficiency and effectiveness of the proposed algorithms for KCPQs and εDJQs. This performance study, conducted on medium and big spatial data sets (real and synthetic) validates that the proposed plane-sweep-based algorithms are very promising in terms of both efficient and effective measures, when neither inputs are indexed. Moreover, the best of the new algorithms is experimentally compared to the best algorithm that is based on the R-tree (a widely accepted access method), for KCPQs and εDJQs, using the same data sets. This comparison shows that the new algorithms outperform R-tree based algorithms, in most cases. 相似文献
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Soil fabric anisotropy tensors are related to the statistical distribution of orientation of different microstructural vector-like entities, most common being the contact normal vectors between particles, which are extremely difficult to determine for real granular materials. On the other hand, void fabric based tensors can be determined by image based quantification methods of voids (graphical approaches), which are well defined and easy to apply to both physical and numerical experiments. A promising void fabric characterization approach is based on the scan line method. Existing scan line based definitions of void fabric anisotropy tensors are shown analytically to inherit a shortcoming, since numerous small void segments in a sample have an inordinate contribution towards unwarranted isotropy. Discrete Element Method (DEM) of analysis subsequently confirms this analytical proof. The fact that such scan line void fabric tensor definitions yield acceptable results when used in conjunction with physical image-based measurements, is shown to be attributed to the natural “cut off” of smaller void segments that occurs during such measurements. This is the motivation to propose using the existing definition of void fabric tensors, with exclusion of void segments less than a “cut off” value associated with an internal length of the granular assembly. In addition, an entirely new void fabric tensor was introduced using the squared length, instead of the length of a void segment, as the weighting factor for the definition of the scan line void fabric tensor. It was found by means of DEM analysis that both alternative definitions are void of the aforementioned shortcoming and compatible with existing image quantification methods of void fabric anisotropy. 相似文献