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排序方式: 共有821条查询结果,搜索用时 15 毫秒
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Erika Aparecida Silveira Golnaz Vaseghi Annelisa Silva de Carvalho Santos Nathalie Kliemann Farzad Masoudkabir Matias Noll Noushin Mohammadifard Nizal Sarrafzadegan Cesar de Oliveira 《International journal of molecular sciences》2020,21(23)
The association between obesity, cancer and cardiovascular disease (CVD) has been demonstrated in animal and epidemiological studies. However, the specific role of visceral obesity on cancer and CVD remains unclear. Visceral adipose tissue (VAT) is a complex and metabolically active tissue, that can produce different adipokines and hormones, responsible for endocrine-metabolic comorbidities. This review explores the potential mechanisms related to VAT that may also be involved in cancer and CVD. In addition, we discuss the shared pharmacological treatments which may reduce the risk of both diseases. This review highlights that chronic inflammation, molecular aspects, metabolic syndrome, secretion of hormones and adiponectin associated to VAT may have synergistic effects and should be further studied in relation to cancer and CVD. Reductions in abdominal and visceral adiposity improve insulin sensitivity, lipid profile and cytokines, which consequently reduce the risk of CVD and some cancers. Several medications have shown to reduce visceral and/or subcutaneous fat. Further research is needed to investigate the pathophysiological mechanisms by which visceral obesity may cause both cancer and CVD. The role of visceral fat in cancer and CVD is an important area to advance. Public health policies to increase public awareness about VAT’s role and ways to manage or prevent it are needed. 相似文献
3.
Nina Georgieva Kostova Elka Kraleva Alla A. Spojakina Erika Godocikova Peter Balaz 《Journal of Materials Science》2007,42(10):3321-3325
The Al-MCM-41 has been used as support to prepare Mo-containing catalysts. The 12- molybdophosphoric heteropoly acid (HPMo)
is used as initial compound. The catalysts are synthesized by two different methods: incipient impregnation with aqueous solution
of the acid and mechanochemical synthesis. The samples were tested in the reaction of the thiophene hydrodesulfurization after
activation with mixture H2 + H2S. The effect of the preparation method of the catalysts on their physicochemical and catalytic properties has been studied.
A partial destruction of the loaded compound is observed in mechanochemically treated sample whereas the aggregates are formed
from the particles of different size in the impregnated sample. The specific surface area of the sample prepared by mechanical–chemical
treatment decreases 2–3 times, while the total pore volume is about four times lower. The HDS activity is higher on the impregnated
sample than on the mechanochemically treated one. 相似文献
4.
Igor Studart Medeiros Erika R. M. Andreeta Antonio C. Hernandes 《Journal of Materials Science》2007,42(11):3874-3877
5.
The theory of syntactic bootstrapping proposes that children use the syntactic frames in which verbs are presented as a source of information about their meaning. The purpose of this study was to investigate the extent to which maternal type and diversity of verb frames are consistent with the requirements of that theory. The uses of 25 common verbs in the speech of 57 mothers to their 1- to 2-year-old children were tabulated and parsed for syntactic frame. Analyses revealed 2 major findings concerning the use of verbs in child-directed speech: (a) Verbs in different semantic categories appear in different syntactic environments, and (b) individual verbs are distinguished by the set of frames in which they appear. These findings support the plausibility of the syntactic bootstrapping hypothesis by demonstrating that children's input provides the structural cues to verb meaning that the syntactic bootstrapping procedure requires. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
6.
Explores several questions relating to historical inquiry in the field of social psychology. During its Golden Age, 1945–1970, social psychology was busy defining different fields and paradigms, building theories, and verifying hypotheses; there was little time and need for reflection. The 1970s saw an era of doubts, critique and crisis, during which the constituted knowledge bases were undermined on a number of fronts: methodological, ethical, and theoretical. Examples of how critical history may serve a heuristic function for social psychology are given. The question of how to conduct historical inquiry is addressed, even for as problematic an object as social psychology's development in France. (French abstract) (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Sandra L. McLellan Erika J. HollisMorgan M. Depas Meredith Van DykeJosh Harris Caitlin O. Scopel 《Journal of Great Lakes research》2007,33(3):566-580
Escherichia coli distribution and persistence in nearshore Lake Michigan were assessed following heavy rains and sanitary sewer overflow (SSO) and combined sewer overflow (CSO) events over a 5-year period, including an 18-day period following 25.4 cm of rainfall in which intensive studies were conducted following multiple CSO and SSO events. E. coli levels in the Milwaukee estuary and harbor following SSO and CSO events ranged from 104 to nearly 105 CFU/100 mL, which were significantly higher (p ≤ 0.05) than levels following rainfall alone. Sites outside of the breakwall but within the contamination plume (e.g., within 2 km of the harbor) were an order of magnitude lower. Locations 2–5 km from the harbor ranged from below detection limits, of < 1 to 5 CFU/100 mL. E. coli levels corrected for dilution based on specific conductivity measurements were lower than what would be expected for loss due to dilution alone, suggesting a combination of die-off and dilution, were responsible for the rapid disappearance of these organisms outside of the harbor. E. coli and fecal coliforms measured concurrently demonstrated that fecal coliforms could be recovered longer than E. coli in the open waters of the lake. E. coli isolated directly from sewage treatment plant influent were found to have a marked increase in antibiotic resistance traits for ten antibiotics commonly used in the human population compared with isolates from two animal sources of fecal pollution. However, E. coli obtained from sewage impacted water (n = 2,513) and from stormwater impacted water (n = 1,465) collected the previous year when there were no sewage overflows, were found to have no significant difference (p < 0.05) in the frequency of resistance when comparing the two conditions. E. coli survival characteristics and population dynamics are most likely influenced by multiple factors in complex systems such as the watershed/estuarine/lake environments of the Great Lakes. 相似文献
9.
Peter K. Windsor Stephen P. Plassmeyer Dominic S. Mattock Jonathan C. Bradfield Erika Y. Choi Bill R. Miller III Byung Hee Han 《International journal of molecular sciences》2021,22(6)
Deposition of amyloid β (Aβ) fibrils in the brain is a key pathologic hallmark of Alzheimer’s disease. A class of polyphenolic biflavonoids is known to have anti-amyloidogenic effects by inhibiting aggregation of Aβ and promoting disaggregation of Aβ fibrils. In the present study, we further sought to investigate the structural basis of the Aβ disaggregating activity of biflavonoids and their interactions at the atomic level. A thioflavin T (ThT) fluorescence assay revealed that amentoflavone-type biflavonoids promote disaggregation of Aβ fibrils with varying potency due to specific structural differences. The computational analysis herein provides the first atomistic details for the mechanism of Aβ disaggregation by biflavonoids. Molecular docking analysis showed that biflavonoids preferentially bind to the aromatic-rich, partially ordered N-termini of Aβ fibril via the π–π interactions. Moreover, docking scores correlate well with the ThT EC50 values. Molecular dynamic simulations revealed that biflavonoids decrease the content of β-sheet in Aβ fibril in a structure-dependent manner. Hydrogen bond analysis further supported that the substitution of hydroxyl groups capable of hydrogen bond formation at two positions on the biflavonoid scaffold leads to significantly disaggregation of Aβ fibrils. Taken together, our data indicate that biflavonoids promote disaggregation of Aβ fibrils due to their ability to disrupt the fibril structure, suggesting biflavonoids as a lead class of compounds to develop a therapeutic agent for Alzheimer’s disease. 相似文献
10.
Margaret Ottaviano Emilio Francesco Giunta Marianna Tortora Marcello Curvietto Laura Attademo Davide Bosso Cinzia Cardalesi Mario Rosanova Pietro De Placido Erica Pietroluongo Vittorio Riccio Brigitta Mucci Sara Parola Maria Grazia Vitale Giovannella Palmieri Bruno Daniele Ester Simeone 《International journal of molecular sciences》2021,22(7)
As widely acknowledged, 40–50% of all melanoma patients harbour an activating BRAF mutation (mostly BRAF V600E). The identification of the RAS–RAF–MEK–ERK (MAP kinase) signalling pathway and its targeting has represented a valuable milestone for the advanced and, more recently, for the completely resected stage III and IV melanoma therapy management. However, despite progress in BRAF-mutant melanoma treatment, the two different approaches approved so far for metastatic disease, immunotherapy and BRAF+MEK inhibitors, allow a 5-year survival of no more than 60%, and most patients relapse during treatment due to acquired mechanisms of resistance. Deep insight into BRAF gene biology is fundamental to describe the acquired resistance mechanisms (primary and secondary) and to understand the molecular pathways that are now being investigated in preclinical and clinical studies with the aim of improving outcomes in BRAF-mutant patients. 相似文献