全文获取类型
收费全文 | 8773篇 |
免费 | 748篇 |
国内免费 | 231篇 |
专业分类
电工技术 | 272篇 |
综合类 | 337篇 |
化学工业 | 1750篇 |
金属工艺 | 312篇 |
机械仪表 | 640篇 |
建筑科学 | 581篇 |
矿业工程 | 153篇 |
能源动力 | 310篇 |
轻工业 | 659篇 |
水利工程 | 126篇 |
石油天然气 | 236篇 |
武器工业 | 31篇 |
无线电 | 1340篇 |
一般工业技术 | 1388篇 |
冶金工业 | 454篇 |
原子能技术 | 139篇 |
自动化技术 | 1024篇 |
出版年
2024年 | 18篇 |
2023年 | 125篇 |
2022年 | 246篇 |
2021年 | 306篇 |
2020年 | 250篇 |
2019年 | 266篇 |
2018年 | 260篇 |
2017年 | 313篇 |
2016年 | 326篇 |
2015年 | 345篇 |
2014年 | 455篇 |
2013年 | 540篇 |
2012年 | 588篇 |
2011年 | 650篇 |
2010年 | 517篇 |
2009年 | 533篇 |
2008年 | 486篇 |
2007年 | 429篇 |
2006年 | 435篇 |
2005年 | 357篇 |
2004年 | 282篇 |
2003年 | 236篇 |
2002年 | 267篇 |
2001年 | 202篇 |
2000年 | 214篇 |
1999年 | 206篇 |
1998年 | 184篇 |
1997年 | 131篇 |
1996年 | 128篇 |
1995年 | 69篇 |
1994年 | 68篇 |
1993年 | 46篇 |
1992年 | 42篇 |
1991年 | 39篇 |
1990年 | 31篇 |
1989年 | 31篇 |
1988年 | 14篇 |
1987年 | 16篇 |
1986年 | 19篇 |
1985年 | 16篇 |
1984年 | 6篇 |
1983年 | 8篇 |
1982年 | 6篇 |
1981年 | 3篇 |
1980年 | 5篇 |
1979年 | 4篇 |
1978年 | 5篇 |
1977年 | 6篇 |
1976年 | 12篇 |
1973年 | 3篇 |
排序方式: 共有9752条查询结果,搜索用时 15 毫秒
1.
2.
Hyun Sun Choi Yun Kee Jo Gwang-Noh Ahn Kye Il Joo Dong-Pyo Kim Hyung Joon Cha 《Advanced functional materials》2021,31(46):2104602
The esophagus is a tubular-shaped muscular organ where swallowed fluids and muscular contractions constitute a highly dynamic environment. The turbulent, coordinated processes that occur through the oropharyngeal conduit can often compromise targeted administration of therapeutic drugs to a lesion, significantly reducing therapeutic efficacy. Here, magnetically guidable drug vehicles capable of strongly adhering to target sites using a bioengineered mussel adhesive protein (MAP) to achieve localized delivery of therapeutic drugs against the hydrodynamic physiological conditions are proposed. A suite of highly uniform microparticles embedded with iron oxide (IO) nanoparticles (MAP@IO MPs) is microfluidically fabricated using the genipin-mediated covalent cross-linking of bioengineered MAP. The MAP@IO MPs are successfully targeted to a specific region and prolongedly retained in the tubular-structured passageway. In particular, orally administered MAP@IO MPs are effectively captured in the esophagus in vivo in a magnetically guidable manner. Moreover, doxorubicin (DOX)-loaded MAP@IO MPs exhibit a sustainable DOX release profile, effective anticancer therapeutic activity, and excellent biocompatibility. Thus, the magnetically guidable locomotion and robust underwater adhesive properties of the proteinaceous soft microbots can provide an intelligent modular approach for targeted locoregional therapeutics delivery to a specific lesion site in dynamic fluid-associated tubular organs such as the esophagus. 相似文献
3.
4.
This paper is prepared in honour of Professor E.T. Brown for his outstanding contributions to rock mechanics and geotechnical engineering and also for his personal influence on the first author's research career in geomechanics and geotechnical engineering. As a result, we have picked a topic that reflects two key research areas in which Professor E.T. Brown has made seminal contributions over a long and distinguished career. These two areas are concerned with the application of the critical state concept to modelling geomaterials and the analysis of underground excavation or tunnelling in geomaterials.Partially due to Professor Brown's influence, the first author has also been conducting research in these two areas over many years. In particular, this paper aims to describe briefly the development of a unified critical state model for geomaterials together with an application to cavity contraction problems and tunnelling in soils. 相似文献
5.
Joon‐Young Jun Sosuke Nakajima Koji Yamazaki Yuji Kawai Hajime Yasui Yasuyuki Konishi 《International Journal of Food Science & Technology》2015,50(4):871-877
Cystoseira hakodatensis is an unutilised brown algae belonging to family Sargassaceae. A crude methanol extract from the algae showed inhibitory effects on the growths of Bacillus cereus and Bacillus licheniformis. To isolate the major antimicrobial agent, a sequential active‐guided isolation procedure was applied: liquid–liquid extraction, column chromatography and bio‐autography. A marked antimicrobial agent (active α) was isolated in hydrophobic fraction and was determined to phenolics without carbohydrates and proteins by phytochemical test. Regarding the antimicrobial potential, the isolated active α showed better inhibitory effects against B. cereus and B. licheniformis at 2 and 4 times of lower concentrations (62.5 and 31.3 μg mL?1) in comparison with epigallocatechin gallate. These results showed that C. hakodatensis is a potential source of antimicrobial agent capable of preventing the growth of the two bacteria. 相似文献
6.
7.
Dr. Yahu A. Liu Dr. Qihui Jin Qiang Ding Dr. Xueshi Hao Tingting Mo Shanshan Yan Dr. Yefen Zou Dr. Zhihong Huang Xiaoyue Zhang Wenqi Gao Dr. Tom Y.-H. Wu Chun Li Dr. Badry Bursalaya Dr. Michael Di Donato Dr. You-Qing Zhang Lisa Deaton Dr. Weijun Shen Dr. Brandon Taylor Anwesh Kamireddy Dr. George Harb Dr. Jing Li Dr. Yong Jia Dr. Andrew M. Schumacher Dr. Bryan Laffitte Dr. Richard Glynne Dr. Shifeng Pan Dr. Peter McNamara Dr. Valentina Molteni Dr. Jon Loren 《ChemMedChem》2020,15(16):1562-1570
Loss of β-cell mass and function can lead to insufficient insulin levels and ultimately to hyperglycemia and diabetes mellitus. The mainstream treatment approach involves regulation of insulin levels; however, approaches intended to increase β-cell mass are less developed. Promoting β-cell proliferation with low-molecular-weight inhibitors of dual-specificity tyrosine-regulated kinase 1A (DYRK1A) offers the potential to treat diabetes with oral therapies by restoring β-cell mass, insulin content and glycemic control. GNF4877, a potent dual inhibitor of DYRK1A and glycogen synthase kinase 3β (GSK3β) was previously reported to induce primary human β-cell proliferation in vitro and in vivo. Herein, we describe the lead optimization that lead to the identification of GNF4877 from an aminopyrazine hit identified in a phenotypic high-throughput screening campaign measuring β-cell proliferation. 相似文献
8.
9.
Seung Han Ryu Seil Kim Young-Tae Kwon Young Ki Park Sung-Oong Kang Hong-Baek Cho Yong-Ho Choa 《应用聚合物科学杂志》2020,137(8):48390
Here, we report a facile approach to electrostatically couple the surface charges of graphite nanoplate (GNP) fillers and poly(methyl methacrylate) (PMMA) polymer particles using ethylene maleic anhydride (EMA) copolymer as an electrostatic coupling agent. Our strategy involved switching the intrinsic repulsive electrostatic interactions between the directly exfoliated GNPs fillers and the PMMA particles to attractive electrostatic surface interactions for preparing core(PMMA)-shell (GNP) precursor in order to optimizing 3-dimensionally dispersed polymer nanocomposite. As a result, the electrical conductivity of the composites dramatically increased by a factor of 16.7 in the EMA-coupled GNP/PMMA composites compared with that of the EMA-free GNP/PMMA composites. In addition, the percolation threshold was also notably reduced from 0.32 to 0.159 vol% after electrostatic coupling of the GNPs fillers and PMMA particles. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137, 48390. 相似文献
10.
UML在网络安全监控系统建模中的应用 总被引:4,自引:0,他引:4
本文首先介绍了UML的特性,然后运用UML对网络安全监控系统中的数据采集系统进行了可视化的建模,建立了系统的需求模型和设计模型的各种视图,最后总结了用UML进行系统需求分析和设计的优越性. 相似文献