Diffuse color patterning using blended electrochromic polymers for proof‐of‐concept adaptive camouflage plaques

A study using three different pairs of electrochromic polymers (ECPs) synthesized onto plaques by means of a modified vapor phase polymerization (VPP) technique is presented. Restriction of the respective polymerization times, allowed both faster and slower polymerizing monomers to be controlled, and produced blended plaques with visually diffuse interfaces. The ECPs within the blended plaques retain their individual electrochromic behavior and when encapsulated into an electrochromic device, show outstanding optical switching performance with little degradation evident over 10,000 cycles, coupled with a switching time of the order of 1 second. Blends also allow multiple diffuse color changes within an electrochromic device, due to the difference in oxidation potentials of the individual ECPs, making them candidates for adaptive camouflage use. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 42158.     

A Novel UWB Pulse Shape Modulation System

In this paper novel modified Hermite polynomial functions for use in impulse radio (ultra-wideband) communications are proposed. With these functions pulse shapes which are orthogonal and have nearly constant pulse width regardless of the pulse order are generated. These properties hold under the effects of differentiation. An M-ary communication system is constructed using these pulse shapes. A Matlab model for generating the pulses is designed and the effect of timing jitter on the performance of the system is investigated by computer simulation.     

Focal Ischemic Injury to the Early Neonatal Rat Brain Models Cognitive and Motor Deficits with Associated Histopathological Outcomes Relevant to Human Neonatal Brain Injury

Neonatal arterial ischemic stroke is one of the more severe birth complications. The injury can result in extensive neurological damage and is robustly associated with later diagnoses of cerebral palsy (CP). An important part of efforts to develop new therapies include the on-going refinement and understanding of animal models that capture relevant clinical features of neonatal brain injury leading to CP. The potent vasoconstrictor peptide, Endothelin-1 (ET-1), has previously been utilised in animal models to reduce local blood flow to levels that mimic ischemic stroke. Our previous work in this area has shown that it is an effective and technically simple approach for modelling ischemic injury at very early neonatal ages, resulting in stable deficits in motor function. Here, we aimed to extend this model to also examine the impact on cognitive function. We show that focal delivery of ET-1 to the cortex of Sprague Dawley rats on postnatal day 0 (P0) resulted in impaired learning in a touchscreen-based test of visual discrimination and correlated with important clinical features of CP including damage to large white matter structures.     

Modelling of interfacial mass transfer in microfluidic solvent extraction: part II. Heterogeneous transport with chemical reaction

The use of a microfluidic device in determining the extraction kinetics of Co^II ions by di-(2-ethylhexyl) phosphoric acid (DEHPA) was demonstrated. Experimental data obtained using a Y-Y-shaped microchannel were modelled using a finite volume method. The contributions of diffusion and reaction transport resistances to the overall rate of mass transfer were obtained. A diffusion-controlled transfer assumption could not account for the experimental data, confirming that transport occurs under a mixed reaction–diffusion resistance regime. The reaction rate constant was determined to be $(2.4 \pm 0.6) \times 10^{-10}$  m/s, in good agreement with corresponding Lewis cell measurements from the literature.     

Evolution or revolution: where next for impact assessment?

Impact assessment (IA) has become one of the most prevalent environmental policy instruments today. Its introduction under the National Environmental Policy Act (US) in 1969 was revolutionary. Perhaps it is not surprising, then, that such a widely used tool has received its share of criticism, including that it fails to meet some of its fundamental goals. Over the last fifty years, IA has broadened in scope and application and embraced new techniques. It has followed evolved, but has not changed fundamentally.

We believe that IA must continue to change to meet the societal and environmental challenges of the 21^st century. But will it be enough for IA to progress through incremental change (evolution), or is a complete overhaul of impact assessment (revolution) needed? We provide some ideas as to what ‘evolution’ and ‘revolution’ may look like, but rather then offering a definitive way forward now, we invite stakeholders to present their thoughts and suggestions at the IAIA19 Annual Conference in Brisbane, which carries the same theme as the title of this article.     

Efficient botnet herding within the Tor network

During 2013 the Tor network had a massive spike in new users as a botnet started using Tor hidden services to hide its C&C (Command and Control) servers. This resulted in network congestion and reduced performance for all users. Tor hidden services are attractive to botnet herders because they provide anonymity for both the C&C servers and the bots. The aim of this paper is to present a superior way that Tor hidden services can be used for botnet C&C which minimises harm to the Tor network while retaining all security benefits.     

Surface changes in polyhydroxyalkanoate films during biodegradation and biofouling

BACKGROUND: Despite the recognition that microbial biofilms play a role in environmental degradation of bioplastics, few studies investigate the relationship between bioplastic biodegradation and microbial colonisation. We have developed protocols based on a combination of confocal laser scanning microscopy and contact angle goniometry to qualitatively and quantitatively map surface changes due to biofilm formation and biopolymer degradation of solvent cast poly(3‐hydroxyalkanoate) films in an accelerated in vitro biodegradation system. RESULTS: A significant regression relationship between biofilm formation and polymer biodegradation (R² = 0.96) was primarily conducted by cells loosely attached to the film surfaces (R² = 0.95), rather than the strongly attached biofilm (R² = 0.78). During biodegradation the surface rugosity of poly(3‐hydroxybutyrate) and poly[(3‐hydroxybutyrate)‐co‐(3‐hydroxyvalerate)] increased by factors of 1.5 and 1.76, respectively. In contrast, poly(3‐hydroxyoctanoate) films showed little microbial attachment, negligible weight loss and insignificant changes in surface rugosity. CONCLUSION: A statistically significant link is established between polymer weight loss and biofilm formation. Our results suggest that this degradation is primarily conducted by cells loosely attached to the polymer rather than those strongly attached. Biofilm formation and its type are dependent upon numerous factors; the flat undifferentiated biofilms observed in this study produce a gradual increase in surface rugosity, observed as an increase in waviness. Copyright © 2008 Society of Chemical Industry     

A longitudinal study of negative affect and self-perceived competence in young adolescents.

In a 4-wave, 2-year longitudinal design, the authors obtained measures of negative affect (NA) and self-perceived competence from 220 boys and 216 girls who were 7th graders at the beginning of this study. NA was operationalized as the common dimension underlying self-reports of depressive symptoms, anxiety symptoms, and negative emotions. Self-perceived competence consisted of 2 higher order constructs: a well-behaved/good-student factor and an attractive/athletic/popular factor. Structural equation modeling revealed very high stability estimates for all constructs. Nevertheless, self-perceived competence in the attractive/athletic/popular domain predicted changes in NA. Conversely, NA predicted changes in self-perceived competence in the well-behaved/good-student domain. The primacy of NA versus self-cognitions depends, in part, on the type of self-cognitions being examined. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Proteomic and other analyses to determine the functional consequences of deregulated kallikrein-related peptidase (KLK) expression in prostate and ovarian cancer

Rapidly developing proteomic tools are improving detection of deregulated kallikrein-related peptidase (KLK) expression, at the protein level, in prostate and ovarian cancer, as well as facilitating the determination of functional consequences downstream. MS-driven proteomics uniquely allows for the detection, identification, and quantification of thousands of proteins in a complex protein pool, and this has served to identify certain KLKs as biomarkers for these diseases. In this review, we describe applications of this technology in KLK biomarker discovery and elucidate MS-based techniques that have been used for unbiased, global screening of KLK substrates within complex protein pools. Although MS-based KLK degradomic studies are limited to date, they helped to discover an array of novel KLK substrates. Substrates identified by MS-based degradomics are reported with improved confidence over those determined by incubating a purified or recombinant substrate and protease of interest, in vitro. We propose that these novel proteomic approaches represent the way forward for KLK research, in order to correlate proteolysis of biological substrates with tissue-related consequences, toward clinical targeting of KLK expression and function for cancer diagnosis, prognosis, and therapies.