Increase in urinary calcium and oxalate after fructose infusion

We have previously shown that an oral glucose load increased both calciuria and oxaluria while the ingestion of fructose induced a rise in calciuria and a decrease in oxaluria. This latter effect remains unclear and might be linked to the reduced intestinal oxalate absorption subsequent to digestive intolerance in some subjects. Such a hypothesis could be enlightened by the study of a parenteral fructose load. Therefore in 7 healthy subjects, we compared the effects of fructose infusion (F) (15 min iv infusion at 0.185 mmol/kg BW/min) to a control glucose infusion (G) on urinary calcium and oxalate. In this study, glycemia and insulinemia increased less after (F) than after (G) (respectively + 21% vs + 216%, p < 0.001 and + 230% vs + 402%, p < 0.05) and phosphatemia decreased less after (F) than after (G) (-7% vs -14%, p < 0.05). Urinary calcium and oxalate increased only after (F) (respectively + 64%, p < 0.01 and + 60%, p < 0.05). Urinary uric acid, another urolithiasis factor, increased after both (F) and (G) (respectively + 45%; p < 0.01 and + 42%; p < 0.01) but uricemia increased only after (F) (+ 25%; p < 0.01). Our results suggest an additional reason to avoid the use of fructose in parenteral nutrition, particularly in individuals with a known history of either calcium oxalate or urate urolithiasis.     

改进的多表达式编程算法在函数发现中的应用

为了提高多表达式编程算法的效率,研究了MEP基本算法的适应度函数、杂交策略和变异策略,对其进行了优化,提出了一种改进的MEP算法.改进的MEP算法采用归一化的均方根差作为适应度函数,采用概率区间来选择杂交算子,并使变异概率在进化过程中随着进化代数和适应值的变化进行动态调整.最后将改进的MEP算法应用于函数发现问题中,对算法的效率进行了验证.实验结果表明,与MEP基本算法相比,改进的MEP算法能够更快速地找到目标函数,算法的效率得到了提高.     

反渗透用于工业污水回用运行中问题的分析

由于工业污水的复杂性,反渗透系统在实际运行过程中会出现很多的问题。通过对太钢除盐水系统运行情况的总结,探讨大型反渗透系统运行过程中常见的问题及应对方法。     

Clinical, biochemical and molecular findings in a patient with X-linked liver glycogenosis followed for 40 years

Phosphorylase kinase (PHK) is a regulatory enzyme in glycogen metabolism. Mutations in the gene encoding the alpha subunit of PHK (PHKA2) have been shown to be responsible for X-linked liver glycogenosis (XLG). XLG, a frequent type of glycogen storage disease, is characterised by hepatomegaly and growth retardation. Two subtypes of XLG have been described: XLG type I patients have a clear-cut PHK deficiency in liver and blood cells, whereas XLG type II patients have a normal or residual activity. Here, we present clinical, biochemical and molecular findings on a liver glycogenosis patient in whom the diagnosis XLG II only became clear after enzyme assays in the liver and identification of the disease-causing mutation. A missense mutation replacing arginine at amino acid position 186 by histidine (R186H) was identified in the PHKA2 gene. Mutations of the same arginine residue have been previously found in at least four other unrelated XLG II patients. CONCLUSION: Arginine at position 186 of the alpha subunit seems to play an important role in the structure or the regulation of PHK. In patients with XLG having normal or residual PHK activity where XLG II is suspected, the identification of mutations in PHKA2 leads to the final classification.     

平圩电厂2号锅炉分隔屏爆管原因分析及其解决措施

安徽淮南平圩发电有限责任公司的2号锅炉是采用美国CE公司技术,由哈尔滨锅炉厂设计制造的我国首批60万千瓦亚临界燃煤锅炉,自2003年7月2日以来,分隔屏左数第4片屏超温爆管,通过计算和试验发现,由于连接第3、4片屏炉外管的阻力大,流量小,并与宽度方向上的热偏差及同屏热偏差,几者叠合,造成3号、4号屏超温严重。通过研究找出了产生超温爆管的原因,并提出了攻关方案,现正在施工中。图9表2     

用于投影的LED光源的特性及发展趋势研究

发光二极管(LED),由于具有寿命长、稳定性好等一系列优点,被广泛应用于各种电子仪表和设备中.随着蓝光LED的面世,LED的三基色发光已经齐备,近年来被逐步用于投影显示中.本文首先介绍了LED投影的分类,随后比较了传统投影和LED投影的工作原理和特性,最后分析了LED投影的现状和存在的问题.     

MGTY250/600-1.1D电牵引采煤机的应用研究

介绍一种最新研究成果 MGTY2 5 0 / 6 0 0 - 1.1D电牵引采煤机 ,并详细论述了其应用范围、性能指标及使用情况。     

Factors affecting the outcome of foetal hydrocephaly

In this study, the authors attempt to provide an account of the factors that affect the outcome of hydrocephaly in 26 foetuses. The hydrocephalus was related to a myelomeningocele in 35% of patients. Sixty-two percent of foetuses showed intra-uterine progression of their hydrocephalus and 50% were shunted postnatally. At a mean follow up of 2 years, the outcome was considered "fair" in 54% of patients. Our findings demonstrate that in foetal hydrocephaly a more favourable outcome is expected in patients with hydrocephalus which does not progress in utero, in whom the labour is not induced before 36 weeks of gestation, who are delivered vaginally weighing more than 2.5 kg and have a head circumference below the 95th centile and a CT cortical mantle thickness of 2 cm and more and who are treated by CSF shunting. The diagnosis of the foetal hydrocephaly at or before 28 weeks of gestation and the presence of a myelomeningocele did not affect the outcome significantly. Neurosurgeons are reminded to keep an open mind for infants with foetal hydrocephaly and to offer active treatment to patients with a potentially favourable outcome.     

电力企业质量目标的建立

建立、实施质量管理体系和安全文明生产达标、创一流电力企业活动的目的,都是为了提高企业的管理水平和整体素质,增强企业的市场竞争能力。电力企业应把两项活动融合在一起,把达标、创一流的考核指标作为企业的质量目标,从而保护质量目标满足ISO9001：2000《质量管理体系要求》标准对质量目标与企业的质量方针保护一致、包括产品所需内容和可测量、可分解的要求。     

Potential antifilarial activity of roots of Asparagus adscendens Roxb, against Setaria cervi in vitro

The effect of dipole-dipole cross correlations on the net nuclear Overhauser effect (NOE) has been analyzed here for realistic systems by extending the three-spin calculations to four and five spins in order to account for additional cross correlations and spin diffusion. These have been compared with the addition of leakage terms to the three-spin system. The additional spins enhance cross-correlation effects on one hand but on the other act as supplementary relaxation pathways for the magnetization to diffuse. This analysis shows that for a linear array of spins in the long-correlation limit, dipole-dipole cross correlations increase net NOE, while spin diffusion decreases it, and that the cumulative effect is a reduced effect of cross correlations. In other geometries and correlation limits, the effect of cross correlations on net NOE is generally small.